Response, disease-free interval and overall survival of cats with nasal planum squamous cell carcinoma treated with a fractionated vs a single-dose protocol of strontium plesiotherapy

Berlato, Davide; Murphy, Suzanne; Laberke, S.; Verganti, Sara

doi:10.1177/1098612x18773913

Cited by 7 publications

(12 citation statements)

References 9 publications

(26 reference statements)

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“…Although a range of different treatments have been used in domestic cats with nasal planum SCC such as strontium (Sr90) plesiotherapy (Berlato et al 2019;Hammond et al 2007), boron neutron capture therapy (Trivillin et al 2008) and intralesional carboplatin and superficial radiotherapy (De Vos, Burm & Focker 2004), radiation therapy remains the most common therapy. Several radiation therapy protocols are in use including a Monday-Wednesday-Friday schedule (Theon et al 1995), hypofractionated (Cunha et al 2010) and accelerated protocols (Gasymova et al 2017).…”

Section: Discussionmentioning

confidence: 99%

Successful treatment of early cutaneous squamous cell carcinoma with hypofractionated radiation therapy in an African lion (Panthera leo)

Weyden¹,

O'Dell²,

Avenant³

et al. 2021

Journal of the South African Veterinary Association

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Cutaneous squamous cell carcinoma (SCC) is a slow growing but locally invasive neoplasm, most commonly caused by prolonged exposure to ultraviolet (UV) radiation. Whilst SCC accounts for 15% of skin tumours in domesticated cats, cutaneous SCC in non-domesticated felids (apart from captive snow leopards) appears to be uncommon, with only three reports in the literature to date. In this report, a captive African lion (Panthera leo) presented with two ulcerative lesions on the nasal planum. Histopathology of the lesions revealed epidermal keratinocyte dysplasia and neoplastic basal- and supra-basal epithelial cells with dyskeratosis and evidence of basement membrane breaching and dermal invasion, consistent with a diagnosis of SCC. There was also evidence of laminar fibrosis and inflammation of the subjacent dermis suggesting that the SCC most likely resulted from UV-induced neoplastic transformation of the epidermal squamous epithelium following actinic keratosis. The lion was treated with hypofractionated radiation therapy and remained in remission until his death (euthanised 17 months later because of age-related chronic renal failure). This is the first report of cutaneous SCC in a lion with evidence of actinic damage and resolution after radiation therapy.

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Section: Discussionmentioning

confidence: 99%

Successful treatment of early cutaneous squamous cell carcinoma with hypofractionated radiation therapy in an African lion (Panthera leo)

Weyden¹,

O'Dell²,

Avenant³

et al. 2021

Journal of the South African Veterinary Association

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“…9,10 In a more recent study, the two protocols were compared and reported similar results to what had been previously published. 5 A complete response was seen in 74% of the cases with a median disease-free interval of 780 days and a recurrence rate of 17%. The disease-free interval of cats treated with a fractionated protocol was significantly longer; however, response rates and overall survival were not statistically different between the two protocols.…”

Section: Introductionmentioning

confidence: 92%

Strontium 90 plesiotherapy for the treatment of eyelid squamous cell carcinoma in eight cats

Russak¹,

Verganti²,

Berlato

2021

Journal of Feline Medicine and Surgery

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Objectives Squamous cell carcinoma (SCC) is the most common eyelid tumour in cats. The main treatment is extensive surgery and the cosmetic outcome can be worrisome for some owners. Strontium 90 (ST-90) plesiotherapy is a therapeutic modality used for superficial tumours, including SCC. The aim of this study was to describe the use and response of feline eyelid SCC to ST-90 plesiotherapy either as single treatment or as adjuvant therapy following surgery. Methods A referral centre clinical database was searched for all cats diagnosed with SCC located on an eyelid. Cats treated with ST-90 plesiotherapy were included. The response to treatment was evaluated visually every 4–6 weeks until complete healing and based on response evaluation criteria in solid tumours (RECIST). Descriptive statistics of the survival were applied to the data collected. Results Eight cats treated between 2014 and 2017 met the inclusion criteria. The median age was 10.8 years. In six cases, ST-90 was used as the only treatment modality, while in two cats it was used as an adjuvant to surgery. Four cats received a single protocol and four a hypofractionated protocol. In the six cats in which ST-90 was used as the primary treatment, the response was 100%. Four cats died at a median time of 9 months (3–17 months) after ST-90 due to causes unrelated to SCC. Of the remaining four cats, three had no signs of recurrence at a median time of 34 months and one was lost to follow-up at 17 months with no signs of recurrence. Conclusions and relevance This small study showed that ST-90 can be used for treatment of eyelid SCC with good therapeutic and cosmetic outcomes.

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“…Numerous treatment modalities are available for the management of feline facial SCCs, including comprehensive surgical excision (including nosectomy), cryotherapy, strontium-90 plesiotherapy (Sr-90), photodynamic therapy, topical immunotherapy with imiquimod cream, electrochemotherapy, intralesional chemotherapy and external beam radiation. 4–11 Treatment of early facial cutaneous SCCs is primarily surgical if feasible. 12 However, surgery for facial cutaneous SCCs, in most cases, is significantly disfiguring, especially for advanced-stage tumours.…”

Section: Introductionmentioning

confidence: 99%

Pilot study evaluating stereotactic body radiation therapy for feline facial squamous cell carcinomas

Swan¹,

Morrow²,

Lurie³

2021

Journal of Feline Medicine and Surgery

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Objectives The use of stereotactic body radiation therapy (SBRT) has not been assessed in advanced-stage feline solar-induced facial squamous cell carcinomas (SCCs). The objective of this study was to provide preliminary data on the use and safety profile of coarse fractions administered with an SBRT regime to manage advanced-stage feline solar-induced facial SCCs. Methods This retrospective study assessed five cats diagnosed with advanced-stage solar-induced facial SCCs that received SBRT as their primary treatment or, in one cat, following failed surgical intervention. Tumour sites received three fractions totalling 26.25–27 Gy over a 3–5-day period. Results All patients developed acute effects following SBRT including alopecia, epilation and erythema. Late effects were mild and included alopecia, variable pigmentation and leukotrichia within radiation fields. All patients are currently alive at the time of submission, with overall survival times ranging from 118 to 991 days. Conclusions and relevance The results suggest that coarse fractions administered with an SBRT technique is a safe and effective treatment tool for the management of advanced-stage feline solar-induced facial SCCs. These data provide preliminary evidence to support larger, prospective studies evaluating the management of feline facial SCCs with SBRT.

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Response, disease-free interval and overall survival of cats with nasal planum squamous cell carcinoma treated with a fractionated vs a single-dose protocol of strontium plesiotherapy

Cited by 7 publications

References 9 publications

Successful treatment of early cutaneous squamous cell carcinoma with hypofractionated radiation therapy in an African lion (Panthera leo)

Successful treatment of early cutaneous squamous cell carcinoma with hypofractionated radiation therapy in an African lion (Panthera leo)

Strontium 90 plesiotherapy for the treatment of eyelid squamous cell carcinoma in eight cats

Pilot study evaluating stereotactic body radiation therapy for feline facial squamous cell carcinomas

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