Responding to Covid-19 in Istanbul: Perspective from Genomic Laboratory

Doğanay, Levent; Ağaoğlu, Nihat Buğra; İrvem, Arzu; Alkurt, Gizem; Yildiz, Jale; Kose, Betsi; Demirkol, Yasemin Kendir; Doğan, Özlem Akgün; Doğanay, Gizem Dinler

doi:10.14744/nci.2020.30075

Cited by 7 publications

(7 citation statements)

References 7 publications

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“…A cross-sectional study was conducted in repurposed Genomic Laboratory (GLAB), Umraniye Teaching and Research Hospital, in Istanbul, with a total of 200 consecutive patients who met the possible case definition for COVID-19 and were hospitalized with moderate-severe disease ( Doganay et al, 2020 ). According to the diagnostic algorithm provided by The Turkish Ministry of Health, the possible cases were defined as those who presented with;…”

Section: Methodsmentioning

confidence: 99%

Does sampling saliva increase detection of SARS-CoV-2 by RT-PCR? Comparing saliva with oro-nasopharyngeal swabs

Doğan

Kose

Ağaoğlu

et al. 2021

Journal of Virological Methods

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Section: Methodsmentioning

confidence: 99%

Does sampling saliva increase detection of SARS-CoV-2 by RT-PCR? Comparing saliva with oro-nasopharyngeal swabs

Doğan

Kose

Ağaoğlu

et al. 2021

Journal of Virological Methods

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“…Istanbul is the epicenter of the ongoing pandemic in Turkey and 60% of the confirmed cases are from Istanbul [ 13 ]. In the current study, seroprevalence of COVID-19 specific IgGs was tested among health care workers (HCWs) from two different pandemic hospitals in Istanbul and one from the neighboring city of Kocaeli.…”

Section: Introductionmentioning

confidence: 99%

Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey

et al. 2021

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COVID-19 is a global threat with an increasing number of infections. Research on IgG seroprevalence among health care workers (HCWs) is needed to re-evaluate health policies. This study was performed in three pandemic hospitals in Istanbul and Kocaeli. Different clusters of HCWs were screened for SARS-CoV-2 infection. Seropositivity rate among participants was evaluated by chemiluminescent microparticle immunoassay. We recruited 813 non-infected and 119 PCR-confirmed infected HCWs. Of the previously undiagnosed HCWs, 22 (2.7%) were seropositive. Seropositivity rates were highest for cleaning staff (6%), physicians (4%), nurses (2.2%) and radiology technicians (1%). Non-pandemic clinic (6.4%) and ICU (4.3%) had the highest prevalence. HCWs in “high risk” group had similar seropositivity rate with “no risk” group (2.9 vs 3.5 p = 0.7). These findings might lead to the re-evaluation of infection control and transmission dynamics in hospitals.

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“…That is, GWAS approaches may reveal findings that were not immediately hypothesized to be involved, such as variants in genes other than those known to be involved in viral pathogenesis and immunity. 112 These findings may be statistically significant, but translating results to clinical uses in the near-term may be challenging despite excitement and perhaps incomplete understanding in the lay press. However, these insights may be important for longer-term and equally important purposes, such as in relation to therapeutic development or understanding which populations may be overall more or less vulnerable to disease.…”

Section: Introductionmentioning

confidence: 99%

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature

LoPresti

Beck

Duggal

et al. 2020

The American Journal of Human Genetics

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Summary The SARS-CoV-2 pandemic raises many scientific and clinical questions. These include how host genetic factors affect disease susceptibility and pathogenesis. New work is emerging related to SARS-CoV-2; previous work has been conducted on other coronaviruses that affect different species. We reviewed the literature on host genetic factors related to coronaviruses, systematically focusing on human studies. We identified 1,832 articles of potential relevance. Seventy-five involved human host genetic factors, 36 of which involved analysis of specific genes or loci; aside from one meta-analysis, all were candidate-driven studies, typically investigating small numbers of research subjects and loci. Three additional case reports were described. Multiple significant loci were identified, including 16 related to susceptibility (seven of which identified protective alleles) and 16 related to outcomes (three of which identified protective alleles). The types of cases and controls used varied considerably; four studies used traditional replication/validation cohorts. Among other studies, 30 involved both human and non-human host genetic factors related to coronavirus, 178 involved study of non-human (animal) host genetic factors related to coronavirus, and 984 involved study of non-genetic host factors related to coronavirus, including involving immunopathogenesis. Previous human studies have been limited by issues that may be less impactful now, including low numbers of eligible participants and limited availability of advanced genomic methods; however, these may raise additional considerations. We outline key genes and loci from animal and human host genetic studies that may bear investigation in the study of COVID-19. We also discuss how previous studies may direct current lines of inquiry.

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Responding to Covid-19 in Istanbul: Perspective from Genomic Laboratory

Cited by 7 publications

References 7 publications

Does sampling saliva increase detection of SARS-CoV-2 by RT-PCR? Comparing saliva with oro-nasopharyngeal swabs

Does sampling saliva increase detection of SARS-CoV-2 by RT-PCR? Comparing saliva with oro-nasopharyngeal swabs

Seroprevalence of coronavirus disease 2019 (COVID-19) among health care workers from three pandemic hospitals of Turkey

The Role of Host Genetic Factors in Coronavirus Susceptibility: Review of Animal and Systematic Review of Human Literature

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