Respiratory viruses in pediatric emergency department patients and their family members

Matienzo, Nelsa; Youssef, Mary; Comito, Devon; Lane, Benjamin; Ligon, Chanel; Morita, Hiromichi; Winchester, Arianna; Decker, Mary; Dayan, Peter; Shopsin, Bo; Shaman, Jeffrey

doi:10.1111/irv.12789

Cited by 10 publications

(11 citation statements)

References 50 publications

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“…After the COVID-19 pandemic, the public was encouraged with the wearing of masks, regular hand washing and frequent disinfection, which greatly reduced the transmission of respiratory pathogens. In this study, we found that the highest positive rate of pathogen detection was HRV, which was consistent with the results of other studies 17 . However, there was no significant different of RSV detection rate compared with 2019.…”

Section: Discussionsupporting

confidence: 93%

The epidemiological features of respiratory tract infection using the multiplex panels detection during COVID-19 pandemic in Shandong province, China

Zhang

Tao

Zou

et al. 2023

Sci Rep

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Respiratory tract infection is one of the most common reasons for both morbidity and mortality worldwide. High attention has been paid to the etiological tracing of respiratory tract infection since the advent of COVID-19. In this study, we aimed to evaluate the epidemiological features of pathogens in respiratory tract infection, especially during COVID-19 pandemic. A total of 7668 patients with respiratory tract infection who admitted to Qilu Hospital of Shandong University from March 2019 to Dec 2021 were retrospectively included. The respiratory tract specimens were detected using a commercial multiplex PCR-based panel assay for common respiratory pathogens including influenza A virus (Flu-A), influenza A virus H1N1 (H1N1), influenza A virus H3N2 (H3N2), influenza B virus (Flu-B), parainfluenza virus (PIV), respiratory syncytial virus (RSV), adenovirus (ADV), Boca virus (Boca), human Rhinovirus (HRV), Metapneumovirus (MPV), Coronavirus (COV), Mycoplasma pneumoniae (MP), and Chlamydia (Ch). The positive rates were compared using a chi-square test. Compared with 2019, the positive rate of pathogen detection during from January 2020 to December 2021 was significantly lower, especially the detection of Flu-A. The positive rate of respiratory pathogen strains was 40.18% during COVID-19 pandemic, and a total of 297 cases (4.69%) of mixed infection with two or more pathogens were detected. There was no statistical difference in the positive rate between male and female patients. However, the positive rates of infection were different among different age groups, with higher incidence of RSV in infancy and toddler group, and MP infection in children and teenager group. While, HRV was the most common pathogen in the adult patients. Moreover, Flu-A and Flu-B were higher in winter, and MP and RSV were higher in spring, autumn and winter. The pathogens such as ADV, BOCA, PIV, and COV were detected without significant seasonal distribution. In conclusion, respiratory pathogen infection rates may vary by age and season, regardless of gender. During the COVID-19 epidemic, blocking transmission routes could help reduce the incidence of respiratory tract infection. The current prevalence of respiratory tract infection pathogens is of great significance for clinical prevention, diagnosis and treatment.

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Section: Discussionsupporting

confidence: 93%

The epidemiological features of respiratory tract infection using the multiplex panels detection during COVID-19 pandemic in Shandong province, China

Zhang

Tao

Zou

et al. 2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…After the COVID-19 pandemic, the public was encouraged with the wearing of masks, regular hand washing and frequent disinfection, which greatly reduced the transmission of respiratory pathogens. In this study, we found that the highest positive rate of pathogen detection was HRV, which was consistent with the results of other studies [17]. However, there was no signi cant different of RSV detection rate compared with 2019.…”

Section: Discussionsupporting

confidence: 92%

The epidemiological features of respiratory tract infection using the multiplex panels detection during COVID-19 pandemic in Shandong province, China

Zhang

Tao

Zou

et al. 2022

Preprint

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High attention has been paid to the etiological tracing of respiratory tract infection (RTI) since the advent of COVID-19. In this study, we aimed to evaluate the epidemiological features of pathogens in RTI, especially during COVID-19 pandemic. In total, 7668 patients with RTI were included from Qilu Hospital of Shandong University between March 2019 and December 2021. The respiratory tract specimens were detected using a commercial multiplex PCR-based panel assay for 13 common respiratory pathogens. Compared with 2019, the positive rate of pathogen detection from January 2020 to December 2021 was significantly lower, especially the detection of Flu-A. The positive rate of respiratory pathogen strains was 40.18% during COVID-19 pandemic, and a total of 297 cases (4.69%) of mixed infection with two or more pathogens were detected. The positive rates of infection were different among different age groups, with higher incidence of RSV in infancy and toddler group, MP infection in children and teenager group, and HRV infection in adult patients. Moreover, Flu-A and Flu-B were higher in winter, and MP and RSV were higher in spring, autumn and winter. The pathogens such as ADV, BOCA, PIV, and COV were detected without significant seasonal distribution. In conclusions, pathogens of RTI may vary by age and season, regardless of gender. During the COVID-19 epidemic, blocking transmission routes could help reduce the incidence of RTI. The current prevalence of pathogens is of great significance for clinical prevention, diagnosis and treatment of RTI.

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“…Several studies have suggested that mixed detections may lead to more severe outcomes, whereas others have not found this association 15 . Our study identified mixed detections in 3.1% of the tested samples, with RV being the most frequently detected virus in these cases, consistent with previous studies 13,14 …”

Section: Discussionsupporting

confidence: 90%

Dynamics of respiratory viruses other than SARS‐CoV‐2 during the COVID‐19 pandemic in Madrid, Spain

Brañas,

Muñoz‐Gallego,

Espartosa

et al. 2023

Influenza Resp Viruses

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The COVID‐19 pandemic and the implemented control measures have impacted the circulation of respiratory‐transmitted pathogens. In this report, we present data from a retrospective study that included 17,883 specimens conducted between 2018 and 2022 in our facility, describing the dynamics of circulation of the main respiratory viruses. We observed a significant decrease in all viral detections (other than SARS‐CoV‐2) starting from March 2020. However, rhinovirus maintained comparable levels to the pre‐pandemic period. Additionally, influenza viruses were not detected during the 2020–2021 season, and respiratory syncytial virus (RSV) exhibited a shift in its seasonality, with an epidemic peak occurring in the summer of 2021.

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Respiratory viruses in pediatric emergency department patients and their family members

Abstract: This is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

Cited by 10 publications

References 50 publications

The epidemiological features of respiratory tract infection using the multiplex panels detection during COVID-19 pandemic in Shandong province, China

The epidemiological features of respiratory tract infection using the multiplex panels detection during COVID-19 pandemic in Shandong province, China

The epidemiological features of respiratory tract infection using the multiplex panels detection during COVID-19 pandemic in Shandong province, China

Dynamics of respiratory viruses other than SARS‐CoV‐2 during the COVID‐19 pandemic in Madrid, Spain

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