Respiratory Viral Shedding in Healthcare Workers Reinfected with SARS-CoV-2, Brazil, 2020

Amorim, Mariene R.; Souza, William Marciel de; Barros, Antonio Carlos; Toledo-Teixeira, Daniel A.; Bispo-dos-Santos, Karina; Simeoni, Camila L.; Parise, Pierina Lorencini; Vieira, Antônio Assis; Forato, Julia; Claro, Ingra Morales; Mofatto, Luciana Souto; Barbosa, Priscilla P; Brunetti, Natália S; França, Emerson Salvador Sousa; Pedroso, Gisele Audrei; Carvalho, Barbara F N; Zaccariotto, Tânia Regina; Krywacz, Kamila Cristina Silva; Vieira, André Schwambach; Mori, Marcelo A.; Farias, Alessandro S.; Pavan, Maria Helena Postal; Bachur, Luís Felipe; Cardoso, Luis Guilherme; Spilki, Fernando Rosado; Sabino, Éster Cerdeira; Faria, Nuno R.; Santos, Magnun Nueldo Nunes; Angerami, Rodrigo Nogueira; Leme, Patrícia Asfora Falabella; Schreiber, Angélica Zaninelli; Moretti, Maria Luíza; Granja, Fabiana; Proença-Módena, José Luiz

doi:10.3201/eid2706.210558

Cited by 19 publications

(28 citation statements)

References 8 publications

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“…A male, 39-years-old patient with comorbidities history, presented two clinical episodes of COVID-19. Few reinfection cases were described worldwide, especially with different lineages detection [14,15]. Although, there are apparently more cases reporting that reinfection presents asymptomatic/mild disease [16], and some cases showed a more severe illness in the second episode [15,17] as the case described here.…”

Section: Discussionmentioning

confidence: 58%

Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

Silva

Demoliner

Hansen

et al. 2021

Preprint

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Multiple variants of Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) are constantly reported across the world. B.1.1.28 lineage has been evolving in Brazil since February 2020 and originated P.1 (VOC) and P.2 (VOI). Here we describe an early case of P.1 primary infection in Southern Brazil in late November 2020, soon after the emergence of the variant in Manaus, Northern Brazil. The same patient suffered a reinfection case by another B1.1.28 variant, namely P.2, in March, 2021. Genomic analysis showed genetically significant differences between the viruses recovered in both infections. P.1 lineage at the first episode and P.2 at the reinfection. We also have investigated the circulation of P.1 in the same region by differential RT-qPCR, showing that this was an isolated case of P.1 at the time of detection, whereas the variant disseminated and became prominent from late January 2021 to the end of March 2021.

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Section: Discussionmentioning

confidence: 58%

Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

Silva

Demoliner

Hansen

et al. 2021

Preprint

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“…Both lineages present with the D614G spike protein mutation that seems to be associated with higher viral load in patients and in animal models, and they are possibly able to infect younger patients more effectively, but it is not associated with more severe COVID-19 and increased mortality 13 , 14 . In the second episode, the detected lineage presented with the V1176F spike protein mutation whose role in COVID-19 remains to be established 15 .…”

Section: Discussionmentioning

confidence: 99%

SARS-CoV-2 reinfection: report of two cases in Southeast Brazil

Yu¹,

Liphaus²,

Ferreira³

et al. 2021

Rev. Inst. Med. trop. S. Paulo

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From February 26, 2020 to March 11, 2021, coronavirus disease 2019 (COVID-19) pandemic resulted in 11,439,558 cases and 277,102 deaths in Brazil. Among them, 2,195,130 cases and 63,965 deaths occurred in Sao Paulo State, Southeast Brazil. The recent emergence and rise of new variants of SARS-CoV-2 is of concern because of their higher transmissibility and possible association with more severe disease. Cases of SARS-CoV-2 reinfections have been described since December 2020 in Brazil. This report describes two cases of COVID-19 reinfection, that occurred five and six months after the first infection, during the second wave of the pandemic in Sao Paulo State. Both patients presented mild symptoms in the two COVID-19 episodes and different lineages of SARS-CoV-2 were identified: B.1.1.33 and B.1.1.28 lineages in case 1 and B1.1.128 and P. 2 lineages in case 2.

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“…This study reported two reinfection cases of SARS-CoV-2 by non-VOC strains in the South of Brazil. Although reinfection cases of SARS-CoV-2 by VOC strains[ 5 – 7 ] have been linked to lower neutralizing capacity antibodies and partial immunity against new variants[ 4 ], a limited and transitory immunity induced by primary infection might be responsible for the occurrence of secondary one reflecting the virus ability to evade the previous immune responses[ 7 ] also in reinfection cases caused by non-VOC strains, as were described in others studies[ 8 – 10 ].…”

Section: Discussionmentioning

confidence: 99%

“…Reinfection cases might happen in convalescent or vaccinated individuals due to the lower neutralizing capacity of SARS-CoV-2 antibodies and partial immunity against new variants[ 4 ]. However, cases of reinfection have been reported for both VOC[ 5 – 7 ] and non-VOC strains[ 8 – 10 ]. In the State of Rio Grande do Sul (RS), South of Brazil, the lineages that were circulating during May to November of 2020 were, most of them, classified as B.1.1, B.1.1.33, B.1.1.248, and B.1.1.49[ 11 , 12 ].…”

Section: Introductionmentioning

confidence: 99%

Reinfection cases by closely related SARS-CoV-2 lineages in Southern Brazil

et al. 2021

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Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is responsible for the pandemic that started in late 2019 and still affects people’s lives all over the world. Lack of protective immunity after primary infection has been involved with reported reinfection cases by SARS-CoV-2. In this study, we described two cases of reinfection caused by non-VOC (Variants of Concern) strains in southern Brazil, being one patient a healthcare worker. The four samples previously positive for SARS-CoV-2 by real-time quantitative reverse transcription polymerase chain reaction (RT-qPCR) were sequenced by a high-performance platform and the genomic analysis confirmed that lineages responsible for infections were B.1.91 and B.1.1.33 (patient 1), and B.1.1.33 and B.1.1.28 (patient 2). The interval between the two positive RT-qPCR for patients 1 and 2 was 45 and 61 days, respectively. This data shows that patients may be reinfected even by very closely related SARS-CoV-2 lineages. Supplementary Information The online version contains supplementary material available at 10.1007/s42770-021-00621-0.

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Respiratory Viral Shedding in Healthcare Workers Reinfected with SARS-CoV-2, Brazil, 2020

Cited by 19 publications

References 8 publications

Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

Early detection of SARS-CoV-2 P.1 variant in Southern Brazil and reinfection of the same patient by P.2

SARS-CoV-2 reinfection: report of two cases in Southeast Brazil

Reinfection cases by closely related SARS-CoV-2 lineages in Southern Brazil

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