Respiratory tract lesions induced by sensory irritants at the RD50 concentration

Buckley, Lorrene A.; Jiang, Xiaoxing; James, R. Arden; Morgan, K.T.; Barrow, Craig S.

doi:10.1016/0041-008x(84)90295-3

Cited by 207 publications

(93 citation statements)

References 19 publications

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“…The concentrations of acrolein used in this study are high (22,81, and 249 ppm), compared with the RD50 concentration of 1.7 ppm (26). It would be interesting to determine whether the use of lower concentrations for a longer time to give equivalent doses would have similar effects on peptidergic nerves.…”

Section: Discussionmentioning

confidence: 99%

Acrolein Depletes the Neuropeptides CGRP and Substance P in Sensory Nerves in Rat Respiratory Tract

Springall¹,

Edginton²,

Price³

et al. 1990

Environmental Health Perspectives

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The mammalian respiratory tract is densely innervated by autonomic and sensory nerves around airways and blood vessels. Subsets of these nerves contain a number of putative neurotransmitter peptides, such as substance P and calcitonin gene-related peptide (CGRP) in sensory nerves and vasoactive intestinal polypeptide (VIP), possibly serving autonomic functions. CGRP is also found in endocrine cells in rat airway epithelium. These peptides are all pharmacologically potent effectors of bronchial and vascular smooth muscle and bronchial secretion. Their functions in vivo are less well established. We have therefore examined the effects of inhaled acrolein, a sensory irritant, on three pulmonary neuropeptides: CGRP, substance P, and VIEP. Groups of rats (n = 3 each) were exposed for 10 min to acrolein in air (Ct = 510, 1858, and 5693 mg.min/m3) or to air alone. Fifteen minutes later they were killed (pentabarbitone IP) and their respiratory tracts were dissected and fixed in 0.4 % p-benzoquinone solution. Cryostat sections were stained by indirect immunofluorescence for a general nerve marker (PGP 9.5) and neuropeptides. The acrolein-treated animals had a dose-related decrease in tracheal substance P-and CGRP-immunoreactive nerve fibers compared with controls. No change was seen in total nerve flber distribution and number (PGP 9.5) or VIP immunoreactivity, nor in CGRP-immunoreactive epithelial endocrine cells. It is concluded that the rat tracheal peptidergic nerves are a sensitive indicator of inhaled irritant substances. Their reduced immunoreactivity may be because of a release of sensory neuropeptides that could play a role in the physiological response to irritant or toxic compounds.

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Section: Discussionmentioning

confidence: 99%

Acrolein Depletes the Neuropeptides CGRP and Substance P in Sensory Nerves in Rat Respiratory Tract

Springall¹,

Edginton²,

Price³

et al. 1990

Environmental Health Perspectives

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“…The mucus layer is important in conditioning the inhaled air and provides a sticky surface for the entrapment of inhaled particles and gases. Because humans are nose breathers, the nasal cavity is the initial site of injury induced by inhaled irritants (12)(13)(14), a common site for particle deposition (15)(16)(17)(18)(19)(20), and a site for the absorption of potentially noxious gases and vapors (21)(22)(23).…”

mentioning

confidence: 99%

Cytopathology of the Nasal Mucosa in Chronic Exposure to Diesel Engine Emission: A Five-Year Survey of Swiss Customs Officers

Glück¹,

Schütz²,

Gebbers³

2002

Environ Health Perspect

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“…Bei Ratten wurde nur eine Dosis von 0,5 ml/kg KG (ca. 600 mg/kg KG) geprüft, die außer Hautschäden keine weiteren Vergiftungserscheinungen verursachte (Bayer 1970 (Buckley et al 1984). Eine Konzentration von 2 ml/m 3 führte bei Ratte und Maus zu klinischen Anzeichen von Atembeschwerden (Frank 1964), war in einer anderen Untersuchung dagegen ohne Effekt (Zapp 1957).…”

Section: Dermale Aufnahmeunclassified

Toluylendiisocyanate [MAK Value Documentation in German language, 1999]

2012

The MAK‐Collection for Occupational Health and Safety

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Veröffentlicht in der Reihe Gesundheitsschädliche Arbeitsstoffe , 28. Lieferung, Ausgabe 1999 Der Artikel enthält folgende Kapitel: Allgemeiner Wirkungscharakter Wirkungsmechanismus Toxikokinetik und Metabolismus Erfahrungen beim Menschen Einmalige Exposition Wiederholte Exposition Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Tierexperimentelle Befunde und In‐vitro‐Untersuchungen Akute Toxizität Subakute, subchronische und chronische Toxizität Wirkung auf Haut und Schleimhäute Allergene Wirkung Reproduktionstoxizität Genotoxizität Kanzerogenität Bewertung

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Respiratory tract lesions induced by sensory irritants at the RD50 concentration

Cited by 207 publications

References 19 publications

Acrolein Depletes the Neuropeptides CGRP and Substance P in Sensory Nerves in Rat Respiratory Tract

Acrolein Depletes the Neuropeptides CGRP and Substance P in Sensory Nerves in Rat Respiratory Tract

Cytopathology of the Nasal Mucosa in Chronic Exposure to Diesel Engine Emission: A Five-Year Survey of Swiss Customs Officers

Toluylendiisocyanate [MAK Value Documentation in German language, 1999]

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