Respiratory tract infections in cytomegalovirus-excreting and nonexcreting infants

Abstract

CMV viral load was not related to clinical symptoms. The frequency of infection with common respiratory viruses in infants was independent of CMV excretion. The course of infection was not more complicated in infants excreting CMV; however, a higher frequency of rhonchi was demonstrated in patients with CMV.

Case-control study of symptoms and neonatal outcome of human milk–Transmitted cytomegalovirus infection in premature infants

“…17 Our findings regarding pulmonary symptoms (ie, days on oxygen or mechanical ventilation) and incidence of BPD are in line with recent data showing no relationship between CMV excretion and risk of BPD or severity of respiratory symptoms in infants admitted with respiratory tract infections. 19,20 But they are in contrast to an earlier report suggesting longer oxygen requirements in infants with early CMV excretion (age < 6 weeks) of presumed postnatal origin. 18 Occasionally more serious symptoms may develop, as suggested by a recent case report of an infant born at 30 weeks GA who developed multiple lung cysts in association with postnatal CMV infection.…”

Cytomegalovirus infection in immunocompetent wheezy infants: the diagnostic value of CMV PCR in bronchoalveolar lavage fluid

“…The literature contains a small number of publications on CMV pneumonitis in immunocompetent wheezy infants. Wejse et al . evaluated the CMV viral load in nasopharyngeal aspirate, throat swab and urine specimens of 201 infants (0–3 years of age) who were hospitalized for ≥1 day due to respiratory tract infection.…”

“…The most common pathogen that leads to wheezing during respiratory infection is respiratory syncytial virus (RSV). There are only a limited number of reports on CMV infection associated with prolonged and intractable wheezing in immunocompetent infants …”

Cytomegalovirus infection of the nasopharynx

“…It was shown that CMV viral load was not related to clinical respiratory symptoms or nasopharyngeal mass. 5 The initial nasopharyngeal biopsy was negative for CMV infection. This might have been caused by the time lag between the two biopsies.…”