Respiratory syncytial virus: viral load, viral decay, and disease progression in children with bronchiolitis

Watanabe, Raí André Silva; Cruz, Jéssica Santiago; Luna, Luciano Kleber de Souza; Alves, Vitória Rodrigues Guimarães; Conte, D.; Lyra, L; Nishiyama, Filipe; Camargo, Bruno Sanchez; Bellei, Nancy

doi:10.1007/s42770-022-00742-0

Cited by 5 publications

(7 citation statements)

References 19 publications

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“…The results showed that the highest viral replication occurs within 48 h after admission, with a significant decrease at the following time points ( p < 0.0001). These results are in agreement with those in the literature [ 7 , 11 , 14 , 17 , 24 , 26 ].…”

Section: Discussionsupporting

confidence: 94%

“…The results showed that the highest viral replication occurs within 48 h after admission, with a significant decrease at the following time points (p < 0.0001). These results are in agreement with those in the literature [7,11,14,17,24,26]. Some authors found that RSV load at admission is affected by the duration of symptoms before hospitalization [11].…”

Section: Discussionsupporting

confidence: 92%

“…The direct role of RSV on the severity of bronchiolitis clinical course is debated because of the different results obtained in previous studies by other authors, who have reported direct, inverse, or absent relationships between higher viral loads and the severity of the disease (see Supplementary Tables S1–S3 ) [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ].…”

Section: Discussionmentioning

confidence: 99%

“…In particular, the role of RSV load as a pathogen-related risk factor is debated. Such great variability in the results obtained from different studies could be related to the analysis of RSV load in relation to diverse outcomes evaluated as markers of bronchiolitis severity: need and duration of oxygen therapy, mechanical ventilation, admission to a pediatric intensive care unit (PICU), hospital length-of-stay (LOS), or clinical scores of severity [ 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 ]. Moreover, many studies based their analyses on the results obtained from a single sample for each included patient, losing the possibility of evaluating viral-replication kinetics [ 9 , 10 , 11 , 12 , 13 , 15 , 16 , 18 , 19 , 20 , 21 , 22 , 23 , 25 ].…”

Section: Introductionmentioning

confidence: 99%

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Respiratory Syncytial Virus-Load Kinetics and Clinical Course of Acute Bronchiolitis in Hospitalized Infants: Interim Results and Review of the Literature

et al. 2023

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Respiratory Syncytial Virus (RSV) bronchiolitis is the leading cause of hospitalization in infants. The role of RSV load in disease severity is still debated. We present the interim results of a prospective monocentric study enrolling previously healthy infants hospitalized for RSV bronchiolitis, collecting nasopharyngeal aspirates every 48 h from admission to discharge, and evaluating RSV-load dynamics in relation to clinical outcome measures of bronchiolitis severity, including: need, type and duration of oxygen therapy, length of hospitalization, and the bronchiolitis clinical score calculated at admission. The results showed that the highest viral replication occurs within the first 48 hours after admission, with a significant decrease at subsequent time points (p < 0.0001). Moreover, higher RSV-RNA values were associated with the need for oxygen therapy (p = 0.03), particularly high-flow nasal cannulae type (p = 0.04), and longer duration of respiratory support (p = 0.04). Finally, higher RSV-load values were correlated with lower white blood cells, especially lymphocyte counts and C-reactive protein levels s (p = 0.03, p = 0.04, and p = 0.01, respectively), as well as with patients of a younger age (p = 0.02). These data suggest that RSV may actively contribute to the clinical severity of bronchiolitis, together with other potential non-viral factors.

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Section: Discussionsupporting

confidence: 94%

“…The results showed that the highest viral replication occurs within 48 h after admission, with a significant decrease at the following time points (p < 0.0001). These results are in agreement with those in the literature [7,11,14,17,24,26]. Some authors found that RSV load at admission is affected by the duration of symptoms before hospitalization [11].…”

Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Respiratory Syncytial Virus-Load Kinetics and Clinical Course of Acute Bronchiolitis in Hospitalized Infants: Interim Results and Review of the Literature

et al. 2023

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“…As comparado ao teste padrão. Esse dado inviabiliza uma aplicação da técnica pois a quantidade de RNA obtido depende de diversos fatores que incluem desde o processo de coleta do material, período da infecção do paciente, idade, condições imunológicas, entre outros 85,86,87 .…”

Section: Discussionunclassified

Padronização da técnica SHERLOCK (>i<Specific High-Sensitivity Enzymatic Reporter Unlocking>/i<) utilizando a proteína Cas13a para diagnóstico do Vírus Respiratório Sincicial em pacientes pediátricos

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Substantial Burden of Nonmedically Attended RSV Infection in Healthy-Term Infants: An International Prospective Birth Cohort Study

Hak,

Venekamp,

Billard

et al. 2023

The Journal of Infectious Diseases

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Background During the first year of life, one in four infants develops a symptomatic respiratory syncytial virus (RSV) infection, yet only half seek medical attention. The current focus on medically attended RSV, therefore, underrepresents the true societal burden of RSV. We assessed the burden of non-medically attended RSV infections and compared them with medically attended RSV. Methods We performed active RSV surveillance until the age of one year in a cohort (n=993) nested within RESCEU, a prospective birth cohort study enrolling healthy term-born infants in five European countries. Parent-reported daily symptoms, medication use, wheezing and impact on family life were analyzed. Results For 97 of 120 (80.1%) non-medically attended RSV episodes sufficient data were available for analysis. In 50.5% (49/97), symptoms lasted ≥15 days. Parents reported impairment in usual daily activities in 59.8% (58/97), worries in 75.3% (73/97), anxiety in 34.0% (33/97), and work absenteeism in 10.8% (10/93) of episodes. Compared with medically attended RSV (n=102, 9 hospital admissions), ReSViNET severity scores were lower (3.5 vs. 4.6, p<0.001), whereas durations of respiratory symptoms and impairment of usual activities were comparable. Conclusion Even when medical attendance is not required, RSV infection poses a substantial burden to infants, families and society at large. These findings are important for policymakers when considering the implementation of RSV immunization in national programs. Clinical Trials Registration NCT03627572

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Respiratory syncytial virus: viral load, viral decay, and disease progression in children with bronchiolitis

Cited by 5 publications

References 19 publications

Respiratory Syncytial Virus-Load Kinetics and Clinical Course of Acute Bronchiolitis in Hospitalized Infants: Interim Results and Review of the Literature

Respiratory Syncytial Virus-Load Kinetics and Clinical Course of Acute Bronchiolitis in Hospitalized Infants: Interim Results and Review of the Literature

Padronização da técnica SHERLOCK (>i<Specific High-Sensitivity Enzymatic Reporter Unlocking>/i<) utilizando a proteína Cas13a para diagnóstico do Vírus Respiratório Sincicial em pacientes pediátricos

Substantial Burden of Nonmedically Attended RSV Infection in Healthy-Term Infants: An International Prospective Birth Cohort Study

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