Respiratory syncytial virus infections in Central Australia

Dede, Apakasiamaka; Isaacs, David; Torzillo, Paul J.; Wakerman, John; Roseby, Robert; Fahy, Rose; Clothier, Tors; White, Andrew; Kitto, Paula

doi:10.1111/j.1440-1754.2009.01614.x

Cited by 19 publications

(25 citation statements)

References 25 publications

(78 reference statements)

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“…Interestingly, our three consecutive years of observation showed the peak of RSV disease always occurred in the dry hot season. This endemic pattern is distinct from that in countries in the temperate zone, where RSV outbreaks normally occur during the winter season [9,18,20]. We found that influenza virus was the second most important virus causing paediatric ARI hospitalisations and circulated throughout the year in this area without a clear peak.…”

Section: Rsv As Leading Viral Pathogen Causing Ari Hospitalisation Inmentioning

confidence: 80%

“…Viruses also play critical roles in the development of ARI or pneumonia in young children. However, elucidating the roles of viral pathogens may be complex as a wide range of viruses, such as respiratory syncytial virus (RSV), human rhinovirus (HRV), influenza virus (FLU) A and FLU B, parainfluenza virus (PIV) and human metapneumovirus (hMPV), are associated with severe forms of childhood ARI including bronchiolitis and pneumonia [5][6][7][8][9]. A systematic review has estimated that 22% of severe ARI episodes among children are related to RSV infections [10].…”

Section: Introductionmentioning

confidence: 99%

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Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections

et al. 2013

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Comprehensive population-based data on the role of respiratory viruses in the development of lower respiratory tract infections (LRTIs) remain unclear. We investigated the incidence and effect of single and multiple infections with respiratory viruses on the risk of LRTIs in Vietnam.Population-based prospective surveillance and a case-control study of hospitalised paediatric patients with acute respiratory infection (ARI) were conducted from April 2007 through to March 2010. Healthy controls were randomly recruited from the same community. Nasopharyngeal samples were collected and tested for 13 respiratory viruses using multiplex PCRs.1992 hospitalised ARI episodes, including 397 (19.9%) with LRTIs, were enrolled. Incidence of hospitalised LRTIs among children aged ,24 months was 2171.9 per 100 000 (95% CI 1947.9-2419.7). The majority of ARI cases (60.9%) were positive for at least one virus. Human rhinovirus (24.2%), respiratory syncytial virus (20.1%) and influenza A virus (12.0%) were the most common and 9.5% had multiple-viral infections. Respiratory syncytial virus and human metapneumovirus infections independently increased the risk of LRTIs. Respiratory syncytial virus further increased the risk, when co-infected with human rhinovirus, human metapneumovirus and parainfluenza virus-3 but not with influenza A virus. The casecontrol analysis revealed that respiratory syncytial virus and influenza A virus increased the risk of ARI hospitalisation but not human rhinovirus.Respiratory syncytial virus is the leading pathogen associated with risk of ARI hospitalisation and LRTIs in Vietnam. @ERSpublications RSV is the leading pathogen associated with risk of ARI hospitalisation and LRTIs in Vietnam

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Section: Rsv As Leading Viral Pathogen Causing Ari Hospitalisation Inmentioning

confidence: 80%

Section: Introductionmentioning

confidence: 99%

Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections

et al. 2013

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“…Thirty‐four studies from 26 countries that were published between 2002 and 2014, with RSV‐associated ARI hospitalization rates for community‐acquired, medically attended, laboratory‐confirmed severe RSV‐ARI in children <5 years of age, were included in the incidence analysis. The incidence estimates of RSV‐associated ARI hospitalization (per 1,000 children per year) were stratified according to age and region (Table ).…”

Section: Resultsmentioning

confidence: 99%

Respiratory syncytial virus hospitalization and mortality: Systematic review and meta‐analysis

Stein

Bont

Zar

et al. 2016

Pediatric Pulmonology

257

206

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SummaryBackground: Respiratory syncytial virus (RSV) is a major public health burden worldwide. We aimed to review the current literature on the incidence and mortality of severe RSV in children globally. Methods: Systematic literature review and meta‐analysis of published data from 2000 onwards, reporting on burden of acute respiratory infection (ARI) due to RSV in children. Main outcomes were hospitalization for severe RSV‐ARI and death. Results: Five thousand two hundred and seventy‐four references were identified. Fifty‐five studies were included from 32 countries. The global RSV‐ARI hospitalization estimates, reported per 1,000 children per year (95% Credible Interval (CrI), were 4.37 (2.98, 6.42) among children <5 years, 19.19 (15.04, 24.48) among children <1 year, 20.01 (9.65, 41.31) among children <6 months and 63.85 (37.52, 109.70) among premature children <1 year. The RSV‐ARI global case‐fatality estimates, reported per 1,000 children, (95% Crl) were 6.21 (2.64, 13.73) among children <5 years, 6.60 (1.85, 16.93) for children <1 year, and 1.04 (0.17, 12.06) among preterm children <1 year. Conclusions: A substantial proportion of RSV‐associated morbidity occurs in the first year of life, especially in children born prematurely. These data affirm the importance of RSV disease in the causation of hospitalization and as a significant contributor to pediatric mortality and further demonstrate gestational age as a critical determinant of disease severity. An important limitation of case‐fatality ratios is the absence of individual patient characteristics of non‐surviving patients. Moreover, case‐fatality ratios cannot be translated to population‐based mortality. Pediatr Pulmonol. 2017;52:556–569. © 2016 The Authors. Pediatric Pulmonology. Published by Wiley Periodicals, Inc.

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“…Within Australia, RSV infections in Alice Springs, Central Australia (23.7°S) occur throughout the year, but peak in winter; which is a typical Southern Australian pattern and similar to the Central Australian winter influenza season. A high burden of RSV disease in Indigenous compared to non‐Indigenous infants has been previously described .…”

Section: What This Paper Addsmentioning

confidence: 87%

Seasonal variability of respiratory syncytial virus infection in the Top End of the Northern Territory (2012–2014)

Fagan

McLeod

Baird

2016

J Paediatrics Child Health

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Respiratory syncytial virus infections in Central Australia

Cited by 19 publications

References 25 publications

Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections

Respiratory syncytial virus: co-infection and paediatric lower respiratory tract infections

Respiratory syncytial virus hospitalization and mortality: Systematic review and meta‐analysis

Seasonal variability of respiratory syncytial virus infection in the Top End of the Northern Territory (2012–2014)

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