Respiratory syncytial virus-associated hospitalizations over three consecutive seasons in children with congenital heart disease

Resch, Bernhard; Kurath‐Koller, Stefan; Hahn, Johannes-Martin; Raith, Wolfgang; Köstenberger, M.; Gamillscheg, Andreas

doi:10.1007/s10096-016-2649-1

Cited by 15 publications

(26 citation statements)

References 24 publications

(49 reference statements)

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“…CHD, irrespective of hemodynamic significance, poses a significant risk for severe RSV infection requiring hospitalization [5, 8, 27–47]. RSVH rates ranged from 14 to 357 per 1000 (Table 1), although comparison of these studies is difficult as a result of differences in the study populations, some of which were not specifically CHD patients, methods used and inclusion criteria.…”

Section: Resultsmentioning

confidence: 99%

“…In multivariate analyses, CHD has been found to be an independent risk factor for RSVH [27, 34, 38, 50]. Data on a population of Danish children with heart disease revealed that cardiomyopathy [odds ratio (OR) 5.84, 95% CI 1.26–27.16] and HS-CHD (OR 1.53, 95% CI 1.04–2.26) were both significant predictors of RSVH [38].…”

Section: Resultsmentioning

confidence: 99%

“…Length of stay in hospital and ICU admissions vary among studies, but, on average, children with CHD and severe RSV infection spent an average of 4.4–14 days in hospital [5, 6, 8, 10, 27, 30, 33, 38–40, 42, 45, 47, 48, 52]. Up to 53% were admitted to ICU with a median stay of 9.5–11 days [5, 6, 10, 27, 30, 44]. A retrospective, single-center study of 30 children with CHD and severe RSV infection reported that more than half (53.3%) were admitted to PICU for treatment [6].…”

Section: Resultsmentioning

confidence: 99%

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Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Infants with Congenital Heart Disease

et al. 2017

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IntroductionThe REGAL (RSV Evidence—a Geographical Archive of the Literature) series provide a comprehensive review of the published evidence in the field of respiratory syncytial virus (RSV) in Western countries over the last 20 years. This fourth publication covers the risk and burden of RSV infection in infants with congenital heart disease (CHD).MethodsA systematic review was undertaken for articles published between January 1, 1995 and December 31, 2015 across PubMed, Embase, The Cochrane Library, and Clinicaltrials.gov. Studies reporting data for hospital visits/admissions for RSV infection among children with CHD as well as studies reporting RSV-associated morbidity, mortality, and healthcare costs were included. The focus was on children not receiving RSV prophylaxis. Study quality and strength of evidence (SOE) were graded using recognized criteria.ResultsA total of 1325 studies were identified of which 38 were included. CHD, in particular hemodynamically significant CHD, is an independent predictor for RSV hospitalization (RSVH) (high SOE). RSVH rates were generally high in young children (<4 years) with CHD (various classifications), varying between 14 and 357/1000 (high SOE). Children (<6 years) with RSV infection spent 4.4–14 days in hospital, with up to 53% requiring intensive care (high SOE). Infants (<2 years) with CHD had a more severe course of RSVH than those without CHD (high SOE). Case fatality rates of up to 3% were associated with RSV infection in children with CHD (high SOE). RSV infection in the perioperative period of corrective surgery and nosocomial RSV infection in intensive care units also represent important causes of morbidity (moderate SOE).ConclusionCHD poses a significant risk for RSVH and subsequent morbidity and mortality. RSV infection often complicates corrective heart surgery. To reduce the burden and improve outcomes, further research and specific studies are needed to determine the longer-term effects of severe RSV infection in young children with CHD.Electronic supplementary materialThe online version of this article (doi:10.1007/s40121-016-0142-x) contains supplementary material, which is available to authorized users.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Infants with Congenital Heart Disease

et al. 2017

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“…22.4% of children were treated at the ICU; the median duration of ICU stay was 10 days (2-70 days), and the median duration of mechanical ventilation was 4 days (0-38 days). Children with hemodynamically significant disease and early heart surgery were less often hospitalized compared to those with delayed cardiac surgery [10].…”

Section: Norwood-i Palliated Hlhs Excessive Pulmonary Perfusion Via mentioning

confidence: 98%

Respiratory Syncytial Virus Infections among Children with Congenital Heart Disease

Daurach¹,

Michel‐Behnke²

2019

The Burden of Respiratory Syncytial Virus Infection in the Young

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Infants and children suffering from congenital heart disease represent a patient cohort particularly at risk for severe RSV infections. Most notably the complication rates in lower respiratory tract infections due to RSV among patients with congenital heart disease are significantly higher compared to other patient collectives. Predisposing factors are altered lung mechanics caused by either increased or decreased pulmonary blood flow, both resulting in a ventilation/ perfusion mismatch causing decreased pulmonary compliance and higher airway resistance. Randomized controlled trials have shown that immunoprophylaxis with palivizumab is beneficial for CHD patients. Guidelines from different national societies suggest administration of palivizumab for infants with CHD in young age injected monthly throughout the RSV season, if the CHD is considered hemodynamically significant.

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“…& Informs clinicians and public health practitioners of changes in the pathogenicity of specific respiratory viral strains [9]. & Allows clinicians to understand disease prevalence and may indirectly guide their practice [10]. & Provides data to administrators and health planners to provide resources to support further spending for the diagnosis, characterization, and control of acute respiratory viral infections [11].…”

Section: Introductionmentioning

confidence: 99%

The Role of Clinical Virology Laboratory and the Clinical Virology Laboratorian in Ensuring Effective Surveillance for Influenza and Other Respiratory Viruses: Points to Consider and Pitfalls to Avoid

Drews

2016

Curr Treat Options Infect Dis

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Respiratory syncytial virus-associated hospitalizations over three consecutive seasons in children with congenital heart disease

Cited by 15 publications

References 24 publications

Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Infants with Congenital Heart Disease

Defining the Risk and Associated Morbidity and Mortality of Severe Respiratory Syncytial Virus Infection Among Infants with Congenital Heart Disease

Respiratory Syncytial Virus Infections among Children with Congenital Heart Disease

The Role of Clinical Virology Laboratory and the Clinical Virology Laboratorian in Ensuring Effective Surveillance for Influenza and Other Respiratory Viruses: Points to Consider and Pitfalls to Avoid

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