Respiratory symptoms do not reflect functional impairment in early CF lung disease

Abstract

Background: Lung disease can develop within the first year of life in infants with cystic fibrosis (CF). However, the frequency and severity of respiratory symptoms in infancy are not known. Methods:We assessed respiratory symptoms in 50 infants with CF and 50 healthy matched controls from two prospective birth cohort studies. Respiratory symptoms and respiratory rate were documented by standardized weekly interviews throughout the first year. Infants performed multiple breath washout in the first weeks of life. Results:We analyzed 4552 data points (2217 in CF). Respiratory symptoms (either mild or severe) were not more frequent in infants with CF (OR:1.1;95% CI:[0.76, 1.59]; p = 0.6). Higher lung clearance index and higher respiratory rate in infants with CF were not associated with respiratory symptoms. Conclusions:We found no difference in respiratory symptoms between healthy and CF infants. These data indicate that early CF lung disease may not be captured by clinical presentation alone.

Early nasal microbiota and subsequent respiratory tract infections in infants with cystic fibrosis

“…This study includes data of infants from two prospective birth cohort studies: the Swiss Cystic Fibrosis Infant Lung Development (SCILD) 17 and the Basel Bern Infant Lung Development (BILD) cohort 37 . Infants were followed throughout the first year of life 38 . Ethics Committee of the Canton of Bern, Switzerland approved the study.…”

“…We investigated 1. β-diversity: compositional microbiota differences between samples based on a dissimilarity matrix, 2. within-subject dissimilarity: β-diversity between consecutive taken swabs with less than three weeks difference of the same infant, 3. α-diversity: microbiota diversity within a sample, and 4. differential bacterial abundances (%). We assessed symptom scores as described previously 38 (Supplementary table 4). We included: a. all samples of all infants; b. samples taken before the first antibiotic treatment.…”