Respiratory symptoms, bronchial hyper‐responsiveness, and eosinophilic airway inflammation in patients with moderate‐to‐severe atopic dermatitis

Abstract

BHR and eosinophilic airway inflammation are more common in patients with AD than in control subjects. The highest prevalences were seen in patients with AD who were SPT positive and had high IgE levels. Longitudinal studies are needed to assess the outcome of patients with signs of airway disease, in order to identify those who need early initiation of asthma treatment.

A 10-year open follow-up of eczema and respiratory symptoms in patients with atopic dermatitis treated with topical tacrolimus for the first 4 years

“…increase in BHR in adults and suggested smoking, but not atopy, as a risk factor (9). BHR and eosinophilic airway inflammation are more common in AD patients than in healthy controls (10). Recently, a murine model showed that epidermal-derived TSLP, which is overexpressed in skin-barrier defects, is the systemic driver of BHR (2).…”

Time for a paradigm shift in asthma treatment: From relieving bronchospasm to controlling systemic inflammation

“…In support of this finding, both eosinophilic airway inflammation and bronchial hyperresponsiveness were recently found to be significantly more common in patients with moderate-to-severe atopic dermatitis compared with control subjects. 18 Sleep and cognitive disorders. There is a link between sleep-related breathing disorders and airway inflammation; approximately two thirds of patients with asthma are awakened once a week by breathing difficulties, and about 40% experience symptoms every night.…”

Effects of Ambient Fine Particles on Pulmonary Function in Children With Mild Atopic Dermatitis

“…[32][33][34][35] Moreover, breathing ambient particles could also adversely affect individuals with AD, who may have preexisting airway inflammation. 12 Skin sensitization to allergen also evokes a strong systemic allergic response, such as elevations in immunoglobulin E, eosinophils, macrophages, and T cells, which may play a role in respiratory allergy in subjects with AD. [36][37][38] Previous animal studies demonstrated that epicutaneous sensitization to an allergen can induce epidermal barrier dysfunction, which leads to augment airway inflammation.…”

“…[9][10][11] Furthermore, several studies have found that the AD patients or nonasthmatic individuals with positive skin prick tests have airway inflammation. 12 on asthmatic patients have reported that a decrease in peak expiratory flow (PEF) is associated with increased daily concentrations of PM. [14][15][16] However, the effects of PMs on lung function in AD patients have not been examined in most previous studies.…”