Respiratory supercomplexes and the functional segmentation of the CoQ pool

Moreno‐Loshuertos, Raquel; Enríquez, José Antonio

doi:10.1016/j.freeradbiomed.2016.04.018

Cited by 33 publications

(23 citation statements)

References 126 publications

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“…In 2008, Acin-Perez and colleagues found that blue native bands corresponding to these so-called respirasomes were enzymatically active and able to transfer electrons from NADH at complex I to complex IV resulting in a measurable rate of O 2 consumption (Acin-Perez et al, 2008). Supercomplex assemblies have been found to vary widely in composition, leading to the development of the plasticity model for respirasome formation, which affects the overall respiratory efficiency of mitochondrial preparations (Moreno-Loshuertos and Enriquez, 2016). Recent work has also demonstrated that supercomplex assembly status also affects mitochondrial ROS production.…”

Section: Supercomplexesmentioning

confidence: 99%

Progress in understanding the molecular oxygen paradox – function of mitochondrial reactive oxygen species in cell signaling

Kuksal

Chalker

Mailloux

2017

Biological Chemistry

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Abstract:The molecular oxygen (O 2 ) paradox was coined to describe its essential nature and toxicity. The latter characteristic of O 2 is associated with the formation of reactive oxygen species (ROS), which can damage structures vital for cellular function. Mammals are equipped with antioxidant systems to fend off the potentially damaging effects of ROS. However, under certain circumstances antioxidant systems can become overwhelmed leading to oxidative stress and damage. Over the past few decades, it has become evident that ROS, specifically H 2 O 2 , are integral signaling molecules complicating the previous logos that oxyradicals were unfortunate by-products of oxygen metabolism that indiscriminately damage cell structures. To avoid its potential toxicity whilst taking advantage of its signaling properties, it is vital for mitochondria to control ROS production and degradation. H 2 O 2 elimination pathways are well characterized in mitochondria. However, less is known about how H 2 O 2 production is controlled. The present review examines the importance of mitochondrial H 2 O 2 in controlling various cellular programs and emerging evidence for how production is regulated. Recently published studies showing how mitochondrial H 2 O 2 can be used as a secondary messenger will be discussed in detail. This will be followed with a description of how mitochondria use S-glutathionylation to control H 2 O 2 production.

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Section: Supercomplexesmentioning

confidence: 99%

Progress in understanding the molecular oxygen paradox – function of mitochondrial reactive oxygen species in cell signaling

Kuksal

Chalker

Mailloux

2017

Biological Chemistry

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“…The advantages appear in four aspects (Dudkina et al, 2015; Genova and Lenaz, 2014; Enriquez, 2016; Lenaz and Genova, 2010; Cogliati et al, 2016; Moreno-Loshuertos and Enriquez, 2016; Genova, 2014; Sazanov, 2015; Liao et al, 2015): (1) CIII and CIV integrated onto CI to form SC can stabilize CI. (2) SCs produce much less ROS (reactive oxygen species).…”

Section: Respiratory Supercomplex Modelmentioning

confidence: 99%

Amazing structure of respirasome: unveiling the secrets of cell respiration

Guo

et al. 2016

Protein Cell

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Respirasome, a huge molecular machine that carries out cellular respiration, has gained growing attention since its discovery, because respiration is the most indispensable biological process in almost all living creatures. The concept of respirasome has renewed our understanding of the respiratory chain organization, and most recently, the structure of respirasome solved by Yang’s group from Tsinghua University (Gu et al. Nature 237(7622):639–643, 2016) firstly presented the detailed interactions within this huge molecular machine, and provided important information for drug design and screening. However, the study of cellular respiration went through a long history. Here, we briefly showed the detoured history of respiratory chain investigation, and then described the amazing structure of respirasome.

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“…The respiratory supercomplexes also have implications for mitochondrial O2 .-and H2O2 production, e.g., oxidant production by complex I is lower when superassembled with complex III [5]. There are several sources of mitochondrial O2 .-and H2O2 within the NADH/NAD + isopotential group (e.g., -ketoglutarate dehydrogenase, pyruvate dehydrogenase, and others) and the QH2/Q isopotential group (e.g., glycerol-P-dehydrogenase and acyl-dehydrogenase) in complexes I and III of the respiratory chain [9].…”

Section: Mitochondrial H2o2: the Link Between Energy Metabolism And Rmentioning

confidence: 99%

“…The involvement of mitochondrial dysfunction and oxidative stress in the pathogenesis of 5 several neurodegenerative diseases represent potential therapeutic targets. Concerning oxidative stress, astrocytes play a key role in providing antioxidant support to neurons [33] through redox regulation of the astrocytic Nrf2 pathway, whereas in neurons the synaptic activity-dependent expression of genes of the GSH and thioredoxin-peroxiredoxin families are the major antioxidant systems.…”

Section: Mitochondrial Function In Neurodegenerative Disordersmentioning

confidence: 99%