Respiratory Severity Score Separates Upper Versus Lower Respiratory Tract Infections and Predicts Measures of Disease Severity

Feldman, Amy S.; Hartert, Tina V.; Gebretsadik, Tebeb; Carroll, Kecia N.; Minton, Patricia A.; Woodward, Kimberly; Larkin, Emma K.; Miller, E. Kathryn; Valet, Robert S.

doi:10.1089/ped.2014.0463

Cited by 26 publications

(23 citation statements)

References 12 publications

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“…In contrast, bronchiolitis induced by respiratory syncytial virus (RSV) or rhinovirus has been consistently associated with increased risk of later asthma in numerous studies. 29,30 For example, in a prospective cohort study of children hospitalized for RSV-induced bronchiolitis in the first year of life, Sigurs et al 31 found that viral bronchiolitis resulting in hospitalization was significantly associated with asthma (defined as 3 episodes of bronchial obstruction) at 3 years of age, which persisted into early adulthood. 32 The Childhood Origins of Asthma study 33 found that in children selected for a high risk of asthma, rhinovirus-induced wheeze was the strongest predictor of wheezing at the age of 3 years, 34 and this effect was carried over to 6 years of age.…”

Section: Respiratory Virusesmentioning

confidence: 99%

Microbes and asthma: Opportunities for intervention

Smits

Hiemstra

Costa

et al. 2016

Journal of Allergy and Clinical Immunology

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The worldwide incidence and prevalence of asthma continues to increase. Asthma is now understood as an umbrella term for different phenotypes or endotypes, which arise through different pathophysiologic pathways. Understanding the many factors contributing to development of the disease is important for the identification of novel therapeutic targets for the treatment of certain asthma phenotypes. The hygiene hypothesis has been formulated to explain the increasing prevalence of allergic disease, including asthma. This hypothesis postulates that decreased exposure at a young age to certain infectious agents as a result of improved hygiene, increased antibiotic use and vaccination, and changes in lifestyle and dietary habits is associated with changes in the immune system, which predispose subjects to allergy. Many microbes, during their coevolution with human subjects, developed mechanisms to manipulate the human immune system and to increase their chances of survival. Improving models of asthma, as well as choosing adequate end points in clinical trials, will lead to a more complete understanding of the underlying mechanisms, thus providing an opportunity to devise primary and secondary interventions at the same time as identifying new molecular targets for treatment. This article reports the discussion and conclusion of a workshop under the auspices of the Netherlands Lung Foundation to extend our understanding of how modulation of the immune system by bacterial, parasitic, and viral infections might affect the development of asthma and to map out future lines of investigation.

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Section: Respiratory Virusesmentioning

confidence: 99%

Microbes and asthma: Opportunities for intervention

Smits

Hiemstra

Costa

et al. 2016

Journal of Allergy and Clinical Immunology

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“…The RSS evaluates the severity of respiratory tract infections in pediatric patients. It was used to distinguish upper from lower respiratory infections and is correlated with the need for hospitalization (8). Because these two scores measure different constructs of respiratory infections, we compared both patients groups using the two scores.…”

Section: Data Collectionmentioning

confidence: 99%

Should equivocal Bordetella pertussis PCR results in children be reported to public health?

Desjardins

Mousseau

Doyon-Plourde

et al. 2018

CCDR

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Introduction: Real-time polymerase chain reaction (PCR) is the preferred method for the diagnosis of pertussis. In Quebec, positive and equivocal results are reportable to public health; in contrast, in Ontario equivocal results are not reportable. Objective: To determine the clinical significance of equivocal, compared with positive results, in children with suspected pertussis. Methods: Retrospective cohort of consecutive patients seen at the Centre Hospitalier Universitaire Sainte-Justine in Montréal, Quebec, with suspected pertussis and tested with a bacterial multiplex PCR (including Bordetella pertussis) between 2015 and 2017. Medical records were reviewed using a standardized form. Univariate analyses (Student's t-test and chi-square test) and multivariable logistic regression were used to compare cases of positive and equivocal results. Results: Of the 1,526 multiplex PCR performed, 109 were positive and 24 equivocal. Both groups were similar in terms of demographics and disease severity assessments, but patients in the equivocal group had less paroxysmal cough (33.3% vs 79.8%, adjusted odds ratio [aOR] 0.11, 95% confidence interval [CI] 0.04-0.29) and whoop (0% vs 18.3%, p<0.001), lower lymphocyte counts (6.6 vs 11.9 x10 9 /L, p=0.008), were more likely to be diagnosed with a viral co-infection (16.7% vs 3.7%, aOR 5.62, 95% CI 1.17-27.54) and were less likely to receive a macrolide (25% vs 89%, aOR 0.04, 95% CI 0.01-0.11). When admitted, patients with equivocal results had a shorter average length of stay (3.3 vs 12.2 days, p=0.001). Conclusion: Although there were similarities in disease severity, children with suspected pertussis who had equivocal PCR results had significantly different clinical presentations compared with those with positive results. In the context of limited public health resources, these results may inform the decision whether or not equivocal results need to be reported to public health by laboratories.

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“…Authors want to compare respiratory severity scoring system like Modified TAL with RSS (Respiratory Severity Score) so that we can find out which of the above two scores are better and whether they can be implemented to assess pediatric ARI patients. 13,14…”

Section: Introductionmentioning

confidence: 99%

Applicability of respiratory severity score and modified TAL criteria in pediatric age group for grading and management of acute respiratory illness

Singh

Kamble

2020

Int J Contemp Pediatr

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Background: Acute respiratory tract infections (ARI) are the leading cause of death in children in the world (11.9 million per year) with the greatest number of deaths occurring in developing countries like India. We compared respiratory severity scoring system RSS (Respiratory Severity Score) with Modified TAL, so that we can find out which of the above scores are better and whether they can be implemented to assess pediatric ARI patients.Methods: This prospective observational study was conducted in Pediatrics wards, Shri Vasantrao Naik Government Medical College, Yavatmal, Maharashtra and data were collected from 290 children below 12 years of age by purposive sampling. All the children presenting with respiratory symptoms were subjected to these scoring system (RSS AND MODIFIED TAL) at the time of admission and were classified based on the scores obtained in respective scoring system. Data was analysed using frequencies, percentages and contingency tables and comparison was made between the above scoring systems to find which one is better applicable in pediatric ARI patient.Results: Incidence of pediatric patients presenting with only respiratory tract infections who are admitted in ward was 25.15 %, with more incidence being reported in children below 12 months (49.31%), males more affected. For both the ARI scoring systems (RSS and MOD TAL) as the severity increased so is the number of patients requiring oxygen and duration of hospitalization increased significantly (p<0.05), with RSS having stronger association.Conclusions: Both the scoring systems predicted that on admission if the score is more than chances of requirement of oxygen is more and also duration of hospitalization is more, with RSS being better predictor.

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Respiratory Severity Score Separates Upper Versus Lower Respiratory Tract Infections and Predicts Measures of Disease Severity

Cited by 26 publications

References 12 publications

Microbes and asthma: Opportunities for intervention

Microbes and asthma: Opportunities for intervention

Should equivocal Bordetella pertussis PCR results in children be reported to public health?

Applicability of respiratory severity score and modified TAL criteria in pediatric age group for grading and management of acute respiratory illness

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