Respiratory sensitivity of rat brain-stem surface to chemical stimuli.

Hori, Takuma; Roth, G.; Yamamoto, William S.

doi:10.1152/jappl.1970.28.6.721

Cited by 42 publications

(10 citation statements)

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“…The observations were confirmed and extended by Mitchell, Loescheke, Massion & Severinghaus (1963a) and Mitchell, Loescheke, Severinghaus, Richardson & Massion (1963b) in the cat, Fencl, Miller & Pappenheimer (1966) and Pappenheimer (1967) in the goat and dog, and Hori, Roth & Yamamoto (1970) in the rat. The contusions stayed the same.…”

Section: Chemosensitivit Y and Reaction Theorysupporting

confidence: 69%

Central chemosensitivity and the reaction theory.

Loeschcke¹

1982

The Journal of Physiology

326

226

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Section: Chemosensitivit Y and Reaction Theorysupporting

confidence: 69%

Central chemosensitivity and the reaction theory.

Loeschcke¹

1982

The Journal of Physiology

326

226

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“…Perfusion with acidic solutions with constant Pc0. also stimulates respiration, whereas perfusion with high PCO, solutions at constant pH fails to increase respiratory activity (Loescheke et al 1958;Mitchell et al 1963;Pappenheimer, 1967;Hori, Roth & Yamamoto, 1970; but see Leusen, 1954b;Cragg, Patterson & Purves, 1977). This suggests that the primary stimulus to the central chemoreceptor is H+, rather than CO2.…”

Section: Introductionmentioning

confidence: 99%

Differential effects of carbon dioxide and pH on central chemoreceptors in the rat in vitro.

Harada¹,

Kuno²,

Wang³

1985

The Journal of Physiology

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“…Acidification of specific regions of the ventral surface of the medulla oblongata (VMS) increases respiratory rate and amplitude, whereas cooling or chemical inhibition of the same or closely adjoining regions reduces respiratory drive and its sensitivity to hypercapnia (Hori et al, 1970;Millhorn et al, 1982Millhorn et al, , 1986Loeschcke, 1982;Fukuda et al, 1993;Nattie, 1999). These effects are attributed to changes in the discharges of superficially located neurons that are either intrinsically sensitive to local acidification or respond to chemical signals released by acidification of surrounding cells (Loeschcke, 1982;Nattie, 1999;Feldman et al, 2003).…”

mentioning

confidence: 99%

Glutamatergic neuronal projections from the marginal layer of the rostral ventral medulla to the respiratory centers in rats

Weston

Stornetta

Guyenet

2004

J of Comparative Neurology

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The marginal layer (ML) that lines the ventral surface of the medulla oblongata (VMS) contains neurons thought to contribute to central chemoreception, the process by which systemic hypercapnia activates respiration. The transmitters and connectivity of ML neurons are poorly known. The present study focuses on a group of nonserotonergic ML neurons, often located in close proximity to the entry point of penetrating blood vessels. These neurons (approximately 300/brain) contain vesicular glutamate transporter2 (VGLUT2) mRNA and are thus probably glutamatergic. They cluster below the caudal half of the facial motor nucleus, lateral to the serotonergic cells of the ML. The projections of serotonergic and nonserotonergic ML neurons were investigated by retrograde labeling with Fluoro-Gold. ML VGLUT2 mRNA-expressing neurons lack spinal projections and innervate the dorsolateral pons and the ipsilateral ventral respiratory column (VRC), most particularly, the region of the pre-Bötzinger complex and rVRG. The latter two regions receive a very small input from ML serotonergic neurons which, instead, heavily innervate the spinal cord. In conclusion, a small region of the VMS marginal layer contains glutamatergic neurons that innervate the main respiratory centers of the medulla oblongata and pons. These glutamatergic neurons are located in a chemosensitive region of the ML and their projections are consistent with a role in central chemoreception. The serotonergic neurons of the ML, though known to be activated by CO(2), probably do not contribute to central chemoreception, given that they innervate sympathetic efferents and project at best very lightly to the VRC.

show abstract

Respiratory sensitivity of rat brain-stem surface to chemical stimuli.

Cited by 42 publications

References 0 publications

Central chemosensitivity and the reaction theory.

Central chemosensitivity and the reaction theory.

Differential effects of carbon dioxide and pH on central chemoreceptors in the rat in vitro.

Glutamatergic neuronal projections from the marginal layer of the rostral ventral medulla to the respiratory centers in rats

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