Respiratory Rhythm Entrainment by Somatic Afferent Stimulation

Potts, Jeffrey T.; Rybak, Ilya A.; Paton, Julian F. R.

doi:10.1523/jneurosci.3881-04.2005

Cited by 118 publications

(146 citation statements)

References 71 publications

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“…Recently, Potts et al (2005) made the important observation that such respiratory entrainment by afferents from skeletal muscles was eliminated after lesion or inhibition of the dorsolateral parabrachial nucleus, indicating a vital role for the latter in synchronizing respiratory movement with rhythmic somatic movement. Pneumotaxic neurons with dendrites extending into vsc as revealed in the present study potentially have access to both respiratory-related information and somatic movement-related information.…”

Section: Pneumotaxic Neurons Integrate Pain And/or Musculoskeletal Inmentioning

confidence: 99%

“…Recent studies in rats suggest that dl-pons is also involved in other respiratory-related functions, including expiratory phaseswitching (Chamberlin and Saper, 1994), sleep apnea (Radulovacki et al, 2004), modulation of respiration by somatic movement (Potts et al, 2005) or nociceptive inputs (Jiang et al, 2004), learning and memory behavior of Hering-Breuer reflex Siniaia et al, 2000;, and the protective diving reflex (Dutschmann and Herbert, 1996). Many of these functions involve other dl-pons loci beyond the mPB-KF complex, such as the lateral parabrachial (lPB) nucleus, intertrigeminal nucleus (IT), and ventrolateral principal trigeminal sensory nucleus (Pr5).…”

Section: Introductionmentioning

confidence: 99%

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Cytoarchitecture of Pneumotaxic Integration of Respiratory and Nonrespiratory Information in the Rat

Song¹,

Yu²,

Poon³

2006

J. Neurosci.

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The "pneumotaxic center" in the Kölliker-Fuse and medial parabrachial nuclei of dorsolateral pons (dl-pons) plays an important role in respiratory phase switching, modulation of respiratory reflex, and rhythmogenesis. Recent electrophysiological and neural tracing data implicate additional pneumotaxic nuclei in (and a broader role for) the dl-pons in integrating respiratory and nonrespiratory information. Here, we examined the cytoarchitecture of the greater pneumotaxic center and its integrating function by using combined extracellular recording and juxtacellular labeling of unit respiratory rhythmic neurons in dl-pons in urethane-anesthetized, vagotomized, paralyzed, and servo-ventilated adult Sprague Dawley rats. Perievent histogram analysis identified four major types of neuronal discharge patterns: inspiratory, expiratory (with three subdivisions), inspiratory-expiratory, and expiratory-inspiratory phase spanning, sometimes with mild tonic background activity. Most recorded neurons were localized in the Kölliker-Fuse and medial parabrachial nuclei, but some were also found in lateral parabrachial nucleus, intertrigeminal nucleus, principal trigeminal sensory nucleus, and supratrigeminal nucleus. The majority of labeled neurons had large and spatially extended dendritic trees that spanned several of these dl-pons subnuclei, often with terminal dendrites ending in the ventral spinocerebellar tract. The distal sections of the primary and higher-order dendrites exhibited rich varicosities, sometimes with dendritic spines. Axons of some labeled neurons were traced all the way to the ventrolateral pons (vl-pons). These findings extend and generalize the classical definition of the pneumotaxic center to include extensive somaticaxonal-dendritic integration of complex descending and ascending respiratory information as well as nociceptive and possibly musculoskeletal and trigeminal information in multiple dl-pons and vl-pons structures in the rat.

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Section: Pneumotaxic Neurons Integrate Pain And/or Musculoskeletal Inmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Cytoarchitecture of Pneumotaxic Integration of Respiratory and Nonrespiratory Information in the Rat

Song¹,

Yu²,

Poon³

2006

J. Neurosci.

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“…The lateral PB is a heterogeneous assemblage of neurons potentially involved in a wide array of respiratory and laryngeal control mechanisms (Farley et al, 1992;Chamberlin and Saper, 1994;Jürgens, 2002;Feldman et al, 2003;Smotherman et al, 2003;Potts et al, 2005). As described previously (Smotherman et al, 2003), injections of the GABA A antagonist bicuculline methiodide (BIC) into the lateral PB caused the dominant second harmonic of the constant-frequency portion of the echolocation call to rise by Ͼ1.5 kHz while the bat was calling at rest.…”

Section: Methodsmentioning

confidence: 95%

“…The PB receives somatosensory feedback regarding lung status (Feldman and Gautier, 1976;Feldman, 1986;Ezure et al, 1998) and feedback regarding the mechanical status of the larynx, including subglottic pressure, vocal fold tension, and relative positions of the laryngeal cartilages (Farley et al, 1992;Sakamoto et al, 1997;Jürgens, 2002). The PB plays a central role in the phenomenon known as locomotor-respiratory coupling (Bramble and Carrier, 1983), in which somatosensory feedback arising from stretch-activated receptors in the arms and legs can evoke respiratory phase switching via projections from the lateral PB to the ventral respiratory group (Potts and Paton, 2001;Potts et al, 2005). In the case of a running animal, entraining respiratory rhythms to locomotor patterns is presumed to increased both respiratory and locomotor efficiency by assuring that competing muscle groups don't work against each other (Bramble and Carrier, 1983).…”

Section: Introductionmentioning

confidence: 99%

A Mechanism for Vocal-Respiratory Coupling in the Mammalian Parabrachial Nucleus

Smotherman¹,

Kobayasi²,

Ma³

et al. 2006

J. Neurosci.

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Mammalian vocalizations require the precise coordination of separate laryngeal and respiratory motor pathways. Precisely how and where in the brain vocal motor patterns interact with respiratory rhythm control is unknown. The parabrachial nucleus (PB) is known to mediate key respiratory reflexes and is also considered a principle component of the mammalian vocal motor pathway, making it a likely site for vocal-respiratory interactions, yet a specific role for the PB in vocalizing has yet to be demonstrated. To investigate the role of the PB in vocal-respiratory coordination, we pharmacologically manipulated synaptic activity in the PB while spontaneously vocalizing horseshoe bats were provoked to emit either short, single syllable or long, multisyllabic vocal motor patterns. Iontophoresis of the GABA A agonist muscimol (MUS) into the lateral PB extended expiratory durations surrounding all vocalizations and increased mean call durations. Alternatively, application of the GABA A antagonist bicuculline methiodide (BIC) shortened expirations and call durations. In addition, BIC eliminated the occurrence of multisyllabic vocalizations. BIC caused a mild increase in quiet breathing rates, whereas MUS tended to slow quiet breathing. The results indicate that GABA A receptor-mediated inhibition in the lateral PB modulates the time course of respiratory phase switching during vocalizing, and is needed for proper coordination of calling and breathing in mammals. We hypothesize that vocal-respiratory rhythm entrainment is achieved at least in part via mechanisms similar to other forms of locomotorrespiratory coupling, namely somatosensory feedback influences on respiratory phase-switching in the lateral PB.

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“…From these experiments we were unable to establish whether the inhibitory inputs to the PB that delayed inspiration during extended vocal sequences came from either descending motor commands or ascending afferent feedback, or a combination of both. However, the ventrolateral PB is known to be a central relay site mediating the reflexive coordination of respiratory rhythms with locomotor activity [8,100]: this general phenomenon known as locomotor-respiratory coupling is mediated by somatic afferent feedback to the same region of the PB in which we were able to manipulate vocal-respiratory coupling in horseshoe bats, which led us to hypothesize that vocal-respiratory coupling in mammals may rely upon somatosensory feedback from the larynx [137] …”

Section: Vocal-respiratory Coordination In Horseshoe Batsmentioning

confidence: 99%

Sensory feedback control of mammalian vocalizations

Smotherman

2007

Behavioural Brain Research

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Somatosensory and auditory feedback mechanisms are dynamic components of the vocal motor pattern generator in mammals. This review explores how sensory cues arising from central auditory and somatosensory pathways actively guide the production of both simple sounds and complex phrases in mammals. While human speech is a uniquely sophisticated example of mammalian vocal behavior, other mammals can serve as examples of how sensory feedback guides complex vocal patterns. Echolocating bats in particular are unique in their absolute dependence on voice control for survival: these animals must constantly adjust the acoustic and temporal patterns of their orientation sounds to efficiently navigate and forage for insects at high speeds under the cover of darkness. Many species of bats also utter a broad repertoire of communication sounds. The functional neuroanatomy of the bat vocal motor pathway is basically identical to other mammals, but the acute significance of sensory feedback in echolocation has made this a profitable model system for studying general principles of sensorimotor integration with regard to vocalizing. Bats and humans are similar in that they both maintain precise control of many different voice parameters, both exhibit a similar suite of responses to altered auditory feedback, and for both the efficacy of sensory feedback depends upon behavioral context. By comparing similarities and differences in the ways sensory feedback influences voice in humans and bats, we may shed light on the basic architecture of the mammalian vocal motor system and perhaps be able to better distinguish those features of human vocal control that evolved uniquely in support of speech and language.

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Respiratory Rhythm Entrainment by Somatic Afferent Stimulation

Cited by 118 publications

References 71 publications

Cytoarchitecture of Pneumotaxic Integration of Respiratory and Nonrespiratory Information in the Rat

Cytoarchitecture of Pneumotaxic Integration of Respiratory and Nonrespiratory Information in the Rat

A Mechanism for Vocal-Respiratory Coupling in the Mammalian Parabrachial Nucleus

Sensory feedback control of mammalian vocalizations

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