Respiratory response to proton pump inhibitor treatment in children with obstructive sleep apnea syndrome and gastroesophageal reflux disease

Wasilewska, Jolanta; Semeniuk, Janusz; Cudowska, Beata; Klukowski, Mark; Dębkowska, Katarzyna; Kaczmarski, Maciej

doi:10.1016/j.sleep.2012.04.016

Cited by 38 publications

(22 citation statements)

References 32 publications

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“…One study identified GER as a risk factor for adenoid regrowth and revision adenoidectomy [20]. It has also been proposed that children with OSA be screened for GER after proton-pump inhibitor therapy was demonstrated to improve AHI scores in children with both OSA and GER [22]. It should be noted that the greatest benefit in this study was seen in school-age children with mild OSA.…”

Section: Discussionmentioning

confidence: 60%

See 1 more Smart Citation

Gastroesophageal reflux as a predictor of complications after adenotonsillectomy in young children

McCormick

Sheyn

Haupert

et al. 2013

International Journal of Pediatric Otorhinolaryngology

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Section: Discussionmentioning

confidence: 60%

“…Several studies have also characterized the impact of reflux on obstructive sleep apnea [20][21][22]. One study identified GER as a risk factor for adenoid regrowth and revision adenoidectomy [20].…”

Section: Discussionmentioning

confidence: 99%

Gastroesophageal reflux as a predictor of complications after adenotonsillectomy in young children

McCormick

Sheyn

Haupert

et al. 2013

International Journal of Pediatric Otorhinolaryngology

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“…24,25 Proton pump inhibitor treatment reduces the obstructive events and improves the apnea hypopnea index in OSA patients. 26,27 In patients with OSA, intrathoracic pressure is increased negatively during an apnea. In addition, hyperventilation after sleep apnea is related to the mechanism of GERD.…”

Section: Discussionmentioning

confidence: 99%

Association Between Non-erosive Reflux Disease and High Risk of Obstructive Sleep Apnea in Korean Population

You¹,

Oh²,

Seo³

et al. 2014

J Neurogastroenterol Motil

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Background/AimsObstructive sleep apnea is becoming more important in gastroesophageal reflux disease (GERD) patients. This study investigated the prevalence of high risk for obstructive sleep apnea in GERD patients in comparison with that in healthy controls using the Berlin Questionnaire. We also investigated the risk factors for obstructive sleep apnea in GERD patients. MethodsWe enrolled 1,007 subjects: 776 healthy controls, 115 individuals with erosive reflux disease, and 116 with non-erosive reflux disease. GERD was diagnosed and classified using endoscopy and a reflux questionnaire. The Berlin Questionnaire was used to evaluate obstructive sleep apnea. ResultsMore patients in the GERD group (28.2%) had higher risk for obstructive sleep apnea than healthy controls (20.4%, P = 0.036). More patients with non-erosive disease (32.8%) had higher risk for obstructive sleep apnea (OSA) than patients with erosive disease (20.9%) and controls (20.4%, P = 0.010). On multivariate analysis, non-erosive disease was a high risk factor for obstructive sleep apnea (odds ratio [OR], 1.82; P = 0.011). Age ≥ 55 years (OR, 1.83; P < 0.001) and a high body mass index (≥ 25 kg/m 2 ) (OR, 2.76; P < 0.001) were also identified as risk factors. Nocturnal GERD was related to high risk for OSA in non-erosive disease patients (OR, 2.97; P = 0.019), but not in erosive disease patients. ConclusionsHigh risk for OSA is more prevalent in GERD patients than in controls. Non-erosive reflux disease, age ≥ 55, and a high BMI are associated with high risk for OSA.

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“…An enzymelinked immunosorbent assay (ELISA) was used to test for anti-HP IgG in sera from patients of both SDB and reference groups. Inclusion criteria for the SDB group were: patients with SDB diagnosed according to previously described criteria [30]; a negative history of HP eradication therapy. Exclusion criteria for the SDB group included: craniofacial anomalies, genetic syndromes, patients taking any medications, and patients with acute infectious symptoms.…”

Section: Study Participantsmentioning

confidence: 99%

“…Pediatric causes of OSAS include most notably adenotonsillar hypertrophy. Other local and general conditions such as genetic factors, craniofacial malformations, neuromuscular diseases, obesity, or gastroesophageal reflux disease have also been implicated as risk factors [3,5,9,14,27,30,31].…”

Section: Introductionmentioning

confidence: 99%

Helicobacter pylori seroprevalence in children with sleep-disordered breathing

Wasilewska

Klukowski

Dębkowska

et al. 2016

International Journal of Pediatric Otorhinolaryngology

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Respiratory response to proton pump inhibitor treatment in children with obstructive sleep apnea syndrome and gastroesophageal reflux disease

Cited by 38 publications

References 32 publications

Gastroesophageal reflux as a predictor of complications after adenotonsillectomy in young children

Gastroesophageal reflux as a predictor of complications after adenotonsillectomy in young children

Association Between Non-erosive Reflux Disease and High Risk of Obstructive Sleep Apnea in Korean Population

Helicobacter pylori seroprevalence in children with sleep-disordered breathing

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