Respiratory response to intraesophageal acid infusion in asthmatic children during sleep

Nocturnal Worsening of Asthma and Sleep-Disordered Breathing

“…Possible mechanisms of GER-induced bronchoconstriction include a vagally mediated reflex, BHR, and microaspiration (39); however, the exact role they play in the genesis of nocturnal asthma remains controversial. Previously, Davis and colleagues (40) found that during sleep the presence of acid in the lower esophagus could trigger bronchoconstriction in asthmatic children with a positive Bernstein test. In the same year, Hughes and colleagues (41) studied nine patients with asthma and seven control subjects overnight (in a sleep laboratory) and found no increase in the incidence of GER at night, so they concluded that this factor did not play any role in the production of the patients' nighttime symptoms.…”

Laparoscopic fundoplication to enhance pulmonary function in children with severe reactive airway disease and gastroesopheagal reflux disease

“…A number of studies have attempted to define the relationship but often the findings have been conflicting. A direct relationship was shown by Larsen et al in a study of children with severe asthma who had a nocturnal component [5]. They performed intraesophageal infusions of normal saline followed by infusion of 0.1 HCl during two periods of the normal sleep cycle.…”

The effects of laparoscopic Nissen fundoplication on patients with severe gastroesophageal reflux disease and steroid-dependent asthma

“…Several studies have attempted to define the relationship, but often the findings have been conflicting. Davis et al [15] demonstrated a direct relationship in a study of children with severe asthma who had a nocturnal component. They performed intraesophageal infusions of normal saline followed by infusion of 0.1 HCl during 2 periods of the normal sleep cycle.…”