Respiratory repercussions in adults with a history of infantile bronchiolitis

Gómez, Roberto; Colás, Carlos; Sebastián, Antonio Arroyo; Arribas, José Luis Carles

doi:10.1016/s1081-1206(10)61411-1

Cited by 18 publications

(11 citation statements)

References 28 publications

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“…The present findings suggest that serious respiratory infections during this critical period of lung development may cause permanent changes making lung function suboptimal, which may be carried over to adult life. This is in accordance with literature showing that young adults with a past history of bronchiolitis or pneumonia had lower lung function and more respiratory symptoms than those without such a history [5,10,11,13,14]. It could be argued that having early respiratory infections is a marker of asthma [7].…”

Section: Discussionsupporting

confidence: 90%

“…A higher prevalence of atopy, defined using specific IgE levels among those who had been hospitalised for lung disease but not among those who had a serious respiratory infection before 5 yrs of age was observed. Similarly, allergic sensitisation in children aged .7 yrs [4,5,7,10] or young adults [4,5,7,10] was related neither to childhood lower respiratory infections [4,5,7,10] nor to doctor treated airway disease [4,5,7,10]. The current study has many methodological strengths.…”

Section: Discussionmentioning

confidence: 75%

“…Only a few studies have examined respiratory repercussions of early childhood respiratory infections in adults. These have found viral bronchiolitis during infancy and childhood pneumonia to be associated with respiratory symptoms and lower lung function in young adults [5,[10][11][12][13][14]. SHAHEEN et al [15] showed that pneumonia before age 2 yrs is related to lower forced expiratory volume in one second (FEV1) in elderly males.…”

mentioning

confidence: 99%

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Do childhood respiratory infections continue to influence adult respiratory morbidity?

Dharmage¹,

Erbas²,

Jarvis³

et al. 2008

European Respiratory Journal

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The aim of the present study was to examine the influence of childhood respiratory infections on adult respiratory health.In 1992-1994, the European Community Respiratory Health Survey recruited community based samples of 20-44-yr-old people from 48 centres in 22 countries. Study participants completed questionnaires and underwent lung function testing. On average, 8.9 yrs later, 29 centres reinvestigated their samples using similar methods. Mixed effects models comprising an estimate for the random variation between centres were used to evaluate the relevant associations.In total, 9,175 patients participated in both studies, of whom 10.9% reported serious respiratory infections (SRI) before 5 yrs of age and 2.8% reported hospitalisation for lung disease (HLD) before 2 yrs if age. SRI was associated with current wheeze (odds ratio (OR) 1.9, 95% confidence interval (CI) 1.7-2.2), asthma (OR 2.5, 95% CI 2.2-3.1), and lower forced expiratory volume in one second (FEV1; 89 mL; 95% CI 54-126), forced vital capacity (FVC; 49 mL; 95% CI 8-90) and FEV1/ FVC ratio (-1.2%; 95% CI -1.8--0.6). Childhood respiratory infections were also associated with new asthma (OR 1.5, 95% CI 1.03-2.0), new wheeze (OR 1.5, 95% CI 1.0-2.4) and persistent wheeze (OR 2.2, 95% CI 1.4-3.6) but not with a decline in lung function. Similar findings were observed for HDL. These associations were significantly consistent across centres. SRI was associated with lower FEV1 when excluding ever asthmatics and current wheezers. The impact of early infections was significantly larger in subjects exposed to maternal or active smoking.The impact of childhood respiratory infections on the respiratory system may not only last into adulthood but also influence development and persistence of adult respiratory morbidity.

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Section: Discussionsupporting

confidence: 90%

Section: Discussionmentioning

confidence: 75%

mentioning

confidence: 99%

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Do childhood respiratory infections continue to influence adult respiratory morbidity?

Dharmage¹,

Erbas²,

Jarvis³

et al. 2008

European Respiratory Journal

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“…Hospitalization, in particular, is a standard measure of severe bronchiolitis used by scientists for Ͼ40 years to conduct epidemiologic studies of bronchiolitis. [11][12][13]21,23,24,[39][40][41][42][43][44] Although most infants will become infected with RSV and 20% to 30% will develop bronchiolitis, only a small percentage of infected infants will be hospitalized. 5,10 In our study cohort, infants with a mother with asthma or both maternal asthma and smoking had the highest risks of being hospitalized for bronchiolitis and having a prolonged hospitalization for bronchiolitis.…”

Section: Discussionmentioning

confidence: 99%

Maternal Asthma and Maternal Smoking Are Associated With Increased Risk of Bronchiolitis During Infancy

Carroll¹,

et al. 2007

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Maternal asthma and maternal smoking during pregnancy are independently associated with the development of bronchiolitis in term, non-low birth weight infants without preexisting cardiac or pulmonary disease. The risk of bronchiolitis among infants with mothers who both have asthma and smoke during pregnancy is approximately 50% greater than that of infants with neither risk factor. Efforts to decrease the illness associated with these 2 risk factors will lead to decreased morbidity from bronchiolitis, the leading cause of hospitalization for severe lower respiratory tract infections during infancy.

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“…There is evidence of an association between viral bronchiolitis during childhood and lung function impairments in later years. Mok and Simpson [2], Sims et al [3], and Gomez et al [4] found statistically significantly reductions in lung function in children with a history of viral bronchiolitis in infancy compared to controls. Gomez et al [4] went further to conclude that a history of bronchiolitis before one year of age determines an increased prevalence of asthma and respiratory symptoms in adult life.…”

Section: Origin Of Small Airways Diseasementioning

confidence: 96%

Small Airways Disease in Asthma

Gulliver¹,

Piedimonte²,

Eid³

2006

CRMR

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Small airway plays a major role in viral infection of the respiratory tract in infants and young children. Indeed these early viral infections have been shown to lead to airway remodeling and early development of non allergic asthma by affecting the expression of critical growth factors. In the old child and adult however, and until very recently, asthma has been considered largely a disease of the large airways. But as our understanding of asthma evolves, it now seems that the disease process in asthma is located in all parts of the tracheobronchial tree, small airways, and alveoli. Small airway remodeling has the potential to produce fixed airflow obstruction, which if untreated and unrecognized can lead chronic obstructive pulmonary disease.With the recognition of the important role of the small airways in the pathogenesis of asthma in infants as well as in adults, more aggressive modalities of treatment are urgently needed in order to have a positive impact on asthma outcome. This article will review the impact of early viral infections on airway remodeling in infants, the role that small airways play in older asthmatics, and finally the potential role of new HFA formulation for the treatment of asthma.

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Respiratory repercussions in adults with a history of infantile bronchiolitis

Cited by 18 publications

References 28 publications

Do childhood respiratory infections continue to influence adult respiratory morbidity?

Do childhood respiratory infections continue to influence adult respiratory morbidity?

Maternal Asthma and Maternal Smoking Are Associated With Increased Risk of Bronchiolitis During Infancy

Small Airways Disease in Asthma

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