Respiratory reactance (Xrs) by Forced Oscillation Technique (FOT) during the first 24h of life in non-intubated preterm infants

Lavizzari, Anna; Veneroni, Chiara; Ottaviani, Valeria; Beretta, Francesco; Fumagalli, Claudia; Colnaghi, Mariarosa; Mosca, Fabio; Dellacà, Raffaele L.

doi:10.1183/13993003.congress-2019.pa1032

Cited by 1 publication

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“…Assessment of respiratory mechanics using FOT in mechanical ventilators is now available to physicians with the Fabian neonatal ventilator [22,23]. However, the Fabian currently only determines the respiratory system reactance measured at an oscillation frequency of f = 10 Hz, which is typical for neonates.…”

Section: Discussionmentioning

confidence: 99%

“…Recently, FOT has been integrated into commercially available neonatal ventilator Fabian (Acutronic, Hirzel, Switzerland) to determine the reactance of the respiratory system of a neonatal patient. Studies described the usefulness of reactance analysis in ventilated [22] or spontaneously breathing neonatal patients [23]. In general, there is no information about the analysis of R rs in HFOV.…”

Section: Introductionmentioning

confidence: 99%

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Assessment of Respiratory System Resistance during High-Frequency Oscillatory Ventilation Based on In Vitro Experiment

2021

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High-frequency oscillatory ventilation (HFOV) is a type of mechanical ventilation with a protective potential characterized by a small tidal volume. Unfortunately, HFOV has limited monitoring of ventilation parameters and mechanical parameters of the respiratory system, which makes it difficult to adjust the continuous distension pressure (CDP) according to the individual patient’s airway status. Airway resistance Raw is one of the important parameters describing the mechanics of the respiratory system. The aim of the presented study was to verify in vitro whether the resistance of the respiratory system Rrs can be reliably determined during HFOV to evaluate Raw in pediatric and adult patients. An experiment was performed with a 3100B high-frequency oscillator, a physical model of the respiratory system, and a pressure and flow measurement system. The physical model with different combinations of resistance and compliance was ventilated during the experiment. The resistance Rrs was calculated from the impedance of the physical model, which was determined from the spectral density of the pressure at airway opening and the spectral cross-density of the gas flow and pressure at airway opening. Rrs of the model increased with an added resistor and did not change significantly with a change in compliance. The method is feasible for monitoring respiratory system resistance during HFOV and has the potential to optimize CDP settings during HFOV in clinical practice.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%