Respiratory Physiology for Intensivists

Alexander, Plato

doi:10.1016/b978-1-4557-0760-7.00014-0

Cited by 2 publications

(1 citation statement)

References 69 publications

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“…The main objective of MV is to increase the gas exchange and reduce the respiratory effort, or the respiratory muscles' load, produced by variations in R or C due to restrictive or obstructive pathologies [43]. This load can be measured by indexes related to weaning success, such as RSBI, WOB, and PI max .…”

Section: Discussionmentioning

confidence: 99%

Web Applications for Teaching the Respiratory System: Content Validation

et al. 2022

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The subject of respiratory mechanics has complex characteristics, functions, and interactions that can be difficult to understand in training and medical education contexts. As such, education strategies based on computational simulations comprise useful tools, but their application in the medical area requires stricter validation processes. This paper shows a statistical and a Delphi validation for two modules of a web application used for respiratory system learning: (I) “Anatomy and Physiology” and (II) “Work of Breathing Indexes”. For statistical validation, population and individual analyses were made using a database of healthy men to compare experimental and model-predicted data. For both modules, the predicted values followed the trend marked by the experimental data in the population analysis, while in the individual analysis, the predicted errors were 9.54% and 25.38% for maximal tidal volume and airflow, respectively, and 6.55%, 9.33%, and 11.77% for rapid shallow breathing index, work of breathing, and maximal inspiratory pressure, respectively. For the Delphi validation, an average higher than 4 was obtained after health professionals evaluated both modules from 1 to 5. In conclusion, both modules are good tools for respiratory system learning processes. The studied parameters behaved consistently with the expressions that describe ventilatory dynamics and were correlated with experimental data; furthermore, they had great acceptance by specialists.

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Section: Discussionmentioning

confidence: 99%

Web Applications for Teaching the Respiratory System: Content Validation

et al. 2022

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Association between preoperative respiratory support and outcomes in paediatric cardiac surgery

et al. 2019

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Background:Preoperative mechanical ventilation is associated with morbidity and mortality following CHD surgery, but prior studies lack a comprehensive analysis of how preoperative respiratory support mode and timing affects outcomes.Methods:We retrospectively collected data on children <18 years of age undergoing cardiac surgery at an academic tertiary care medical centre. Using multivariable regression, we examined the association between modes of preoperative respiratory support (nasal cannula, high-flow nasal cannula/noninvasive ventilation, or invasive mechanical ventilation), escalation of preoperative respiratory support, and invasive mechanical ventilation on the day of surgery for three outcomes: operative mortality, postoperative length of stay, and postoperative complications. We repeated our analysis in a subcohort of neonates.Results:A total of 701 children underwent 800 surgical procedures, and 40% received preoperative respiratory support. Among neonates, 243 patients underwent 253 surgical procedures, and 79% received preoperative respiratory support. In multivariable analysis, all modes of preoperative respiratory support, escalation in preoperative respiratory support, and invasive mechanical ventilation on the day of surgery were associated with increased odds of prolonged length of stay in children and neonates. Children (odds ratio = 3.69, 95% CI 1.2–11.4) and neonates (odds ratio = 8.97, 95% CI 1.31–61.14) on high-flow nasal cannula/noninvasive ventilation had increased odds of operative mortality compared to those on room air.Conclusion:Preoperative respiratory support is associated with prolonged length of stay and mortality following CHD surgery. Knowing how preoperative respiratory support affects outcomes may help guide surgical timing, inform prognostic conversations, and improve risk stratification models.

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Respiratory Physiology for Intensivists

Cited by 2 publications

References 69 publications

Web Applications for Teaching the Respiratory System: Content Validation

Web Applications for Teaching the Respiratory System: Content Validation

Association between preoperative respiratory support and outcomes in paediatric cardiac surgery

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