Respiratory Outcomes After 6 Months of Hospital Discharge in Patients Affected by COVID-19: A Prospective Cohort

Prestes, Gabriele da Silveira; Simon, Carla Sasso; Walz, Roger; Ritter, Cristiane; Dal‐Pizzol, Felipe

doi:10.3389/fmed.2022.795074

Cited by 9 publications

(11 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Almost half of the affected sample was between 30 and 49 years old, and the majority were female. These findings are consistent with other studies indicating that COVID-19 is more prevalent in females and those ages 30 to 60 years 14 , 30 , 31 .…”

Section: Discussionsupporting

confidence: 93%

A prospective cohort study assessing the relationship between long-COVID symptom incidence in COVID-19 patients and COVID-19 vaccination

Hamdh

Nazzal

2023

Sci Rep

View full text Add to dashboard Cite

Current studies about the long-term effects of COVID-19 show a wide range of symptoms. This prospective cohort study aimed to find the incidence of long-COVID symptoms and the associated risk factors. We followed 669 confirmed COVID-19 patients. Sociodemographic and clinical data were extracted from medical records and collected via semi-structured telephone interviews on days 10, 30, 60, and 90. The incidence of long-COVID symptoms was 41.6% (95% CI 37.8–45.4%). Females [aOR = 1.5 (95% CI 1.1–2.3)], the elderly [aOR = 4.9 (95% CI 2.0–11.3)], and those who required hospitalization [aOR = 5.0 (95% CI 1.3–3.7)] were at a higher risk of developing long-COVID. Patients with dyspnea at day 10 [aOR: 2.4 (95% CI 1.6–3.7] and fatigue at day 60 [aOR: 3.1 (95% CI 1.5–6.3] were also at risk. While non-vaccinated patients were almost seven times more likely to report long-COVID symptoms than vaccinated patients [aOR: 6.9 (95% CI 4.2–11.3)]. In conclusion, long-COVID was common among COVID-19 patients, with higher rates among females, older age groups, hospitalized patients, and those with dyspnea and fatigue, while vaccination provided protection. Interventions should educate health professionals, raise general public awareness about the risks and consequences of Long COVID, and the value of vaccination.

show abstract

Section: Discussionsupporting

confidence: 93%

A prospective cohort study assessing the relationship between long-COVID symptom incidence in COVID-19 patients and COVID-19 vaccination

Hamdh

Nazzal

2023

Sci Rep

View full text Add to dashboard Cite

show abstract

“…We identified 4710 records through PubMed, EMBASE, and ScienceDirect database searches. A total of 51 articles (i.e., 33,573 patients) were selected for analysis based on the inclusion and exclusion criteria [ 6 , 15 , 16 , 18 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 , 64 , 65 , 66 , 67 ]. The study selection process was documented in Figure 1 .…”

Section: Resultsmentioning

confidence: 99%

Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis

Deng

et al. 2022

IJERPH

View full text Add to dashboard Cite

Although many studies of long COVID-19 were reported, there was a lack of systematic research which assessed the differences of long COVID-19 in regard to what unique SARS-CoV-2 strains caused it. As such, this systematic review and meta-analysis aims to evaluate the characteristics of long COVID-19 that is caused by different SARS-CoV-2 strains. We systematically searched the PubMed, EMBASE, and ScienceDirect databases in order to find cohort studies of long COVID-19 as defined by the WHO (Geneva, Switzerland). The main outcomes were in determining the percentages of long COVID-19 among patients who were infected with different SARS-CoV-2 strains. Further, this study was registered in PROSPERO (CRD42022339964). A total of 51 studies with 33,573 patients was included, of which three studies possessed the Alpha and Delta variants, and five studies possessed the Omicron variant. The highest pooled estimate of long COVID-19 was found in the CT abnormalities (60.5%; 95% CI: 40.4%, 80.6%) for the wild-type strain; fatigue (66.1%; 95% CI: 42.2%, 89.9%) for the Alpha variant; and ≥1 general symptoms (28.4%; 95% CI: 7.9%, 49.0%) for the Omicron variant. The pooled estimates of ≥1 general symptoms (65.8%; 95% CI: 47.7%, 83.9%) and fatigue were the highest symptoms found among patients infected with the Alpha variant, followed by the wild-type strain, and then the Omicron variant. The pooled estimate of myalgia was highest among patients infected with the Omicron variant (11.7%; 95%: 8.3%, 15.1%), compared with those infected with the wild-type strain (9.4%; 95%: 6.3%, 12.5%). The pooled estimate of sleep difficulty was lowest among the patients infected with the Delta variant (2.5%; 95%: 0.2%, 4.9%) when compared with those infected with the wild-type strain (24.5%; 95%: 17.5%, 31.5%) and the Omicron variant (18.7%; 95%: 1.0%, 36.5%). The findings of this study suggest that there is no significant difference between long COVID-19 that has been caused by different strains, except in certain general symptoms (i.e., in the Alpha or Omicron variant) and in sleep difficulty (i.e., the wild-type strain). In the context of the ongoing COVID-19 pandemic and its emerging variants, directing more attention to long COVID-19 that is caused by unique strains, as well as implementing targeted intervention measures to address it are vital.

show abstract

“…(8) Another study proved that female gender, comorbidity index, and age were associated with worse lung function. (9) Hypertension, dyslipidemia, cardiovascular disease, and type 2 diabetes mellitus (T2DM) were among the comorbidities strongly associated with complaints in patients with long Covid. (10) However, we could not show such an association in multivariate analysis in our study.…”

Section: Discussionmentioning

confidence: 99%

Pulmonary Manifestations and their Determinants in Long Covid Patients: A Retrospective Cohort Study after One Year Follow-Up, From Iran

Fallahi,

Lankarani,

Honarvar

et al. 2023

Preprint

View full text Add to dashboard Cite

Background and aim Post-Covid-19 condition or long covid syndrome (LCS), including both pulmonary and extra-pulmonary manifestations, were reported in about 90% of covid-19 infected hospitalized patients. This study aims to determine pulmonary manifestations of LCS and its associated factors in hospitalized patients. Methods This retrospective cohort study was conducted on patients who were admitted due to Covid-19 in the referral hospital of Covid-19 in Shiraz, Iran. The list of patients with a history of hospital admission due to Covid-19 was provided by the deputy for curative affairs of Shiraz University of Medical Sciences (SUMS), Shiraz, Iran. Then, by systematic randomized sampling method, 300 patients were selected and invited to come to Motahari Clinic affiliated to SUMS, Shiraz, Iran. A general questionnaire including demographic and socioeconomic factors was filled out for every patient. We evaluated the patients in three stages: pre-hospital, hospital, and post-hospital. A Modified Medical Research Council (mMRC) questionnaire was also used for dyspnea assessment and pulmonary function test (PFT) was performed for examining lung function. Finding 290 patients with a mean age of 53.23±13.4, and female to male ratio of 1.65, accepted our invitation and referred to the clinic. Of the participants, 115(39.7%) were previously diagnosed with diabetes mellitus (DM), cardiovascular disease (CVD), or obesity (BMI > 30). The mean length of hospital stay due to covid-19 was 8.78±1 days (median = six days) while 47(16.2%) had a history of admission to ICU. This study was conducted about one year after the patients were discharged from the hospital (mean=327±124.4 days, median = 306 days). Out of all, 176 (60%) had mMRC score≥1, including 66 (22.8%) with severe dyspnea. Furthermore, 147 (50.7%) had abnormal PFTs, including 123 (42.4%) with impaired TLco and 46 (15.8%) with a restrictive pattern of lung disease. In univariate analysis, patients who were admitted to the ICU (p=0.002) or who had received corticosteroids (p=0.024) during hospital admission showed milder dyspnea after one-year follow-up. Logistic regression revealed a reverse association between ICU admission and the severity of dyspnea (p=0.04). Conclusion Appropriate treatment and care during hospitalization and continued regular follow-up for at least one year after discharge is crucial to provide a significant enhancement of Covid-19 infected patient's overall prognosis. The Long-term pulmonic consequences of Covid-19 need special attention.

show abstract

Respiratory Outcomes After 6 Months of Hospital Discharge in Patients Affected by COVID-19: A Prospective Cohort

Cited by 9 publications

References 19 publications

A prospective cohort study assessing the relationship between long-COVID symptom incidence in COVID-19 patients and COVID-19 vaccination

A prospective cohort study assessing the relationship between long-COVID symptom incidence in COVID-19 patients and COVID-19 vaccination

Comparison of Long COVID-19 Caused by Different SARS-CoV-2 Strains: A Systematic Review and Meta-Analysis

Pulmonary Manifestations and their Determinants in Long Covid Patients: A Retrospective Cohort Study after One Year Follow-Up, From Iran

Contact Info

Product

Resources

About