Respiratory Oscillometry in Newborn Infants: Conventional and Intra-Breath Approaches

Radics, Bence; Gyurkovits, Zita; Makan, Gergely; Gingl, Zoltán; Czövek, Dorottya; Hantos, Zoltán

doi:10.3389/fped.2022.867883

Cited by 4 publications

(4 citation statements)

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“…Currently, no oscillometry reference equations exist for African populations, despite the high burden of respiratory disease in the region. Additionally, normative data on the novel intra-breath oscillometry measures are scant [ 8 ] and are not available for paediatric populations beyond infancy [ 9 , 36 ]. Recent technical standards for oscillometry equipment and testing, developed by a European Respiratory Society (ERS) task force have highlighted the lack of appropriate paediatric reference standards, especially for underrepresented populations [ 37 ].…”

Section: Introductionmentioning

confidence: 99%

Normal values of respiratory oscillometry in South African children and adolescents

Chaya

MacGinty²,

Jacobs³

et al. 2023

ERJ Open Res

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IntroductionNon-invasive measurement of respiratory impedance by oscillometry can be used in young children from 3 years and those unable to perform forced respiratory manoeuvres. It can discriminate between healthy children and those with respiratory disease. However, its clinical application is limited by the lack of reference data for African paediatric populations.AimTo develop reference equations for oscillometry outcomes in South African children and adolescents.MethodsHealthy subjects, enrolled in the Drakenstein Child Health Study, HIV uninfected adolescents in the Cape Town Adolescent Antiretroviral Cohort and healthy children attending surgical outpatient clinics at Red Cross War Memorial Children's Hospital were measured with conventional spectral (6–32 Hz) and intra-breath (10 Hz) oscillometry. Stepwise linear regression was used to assess the relationship between respiratory variables and anthropometric predictors (height, sex, ancestry) to generate reference equations.ResultsA total of 692 subjects, 48.4% female, median age of 5.2 years (range: 3–17 years) were included. The median interquartile range (IQR) for weight for age z-score and height for age z-score was −0.42 (−1.11; 0.35) and −0.65 (−1.43; 0.35), respectively. Stepwise regression demonstrated that all the variables were significantly dependent on height only. Comparison to previous reference data indicated slightly higher resistance and lower compliance values in the smallest children.ConclusionWe established the first respiratory oscillometry reference equations for African children and adolescents, which will facilitate use in early identification and management of respiratory disease. Our results suggest differences in oscillometry measures by ancestry but also highlight the lack of standardisation in methodology.

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Section: Introductionmentioning

confidence: 99%

Normal values of respiratory oscillometry in South African children and adolescents

Chaya

MacGinty²,

Jacobs³

et al. 2023

ERJ Open Res

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“…A minimum of 20 regular breathing periods with no artefacts were collected for each infant for intrabreath analysis, and the recording was repeated if necessary. Details of equipment, signal processing and Zrs analysis are previously described 14. Zrs was characterised by resistance (Rrs) and reactance (Xrs) at end expiration (R eE and X eE , respectively) and at end inspiration (R eI and X eI , respectively).…”

Section: Methodsmentioning

confidence: 99%

“…Details of equipment, signal processing and Zrs analysis are previously described. 14 Zrs was characterised by resistance (Rrs) and reactance (Xrs) at end expiration (R eE and X eE , respectively) and at end inspiration (R eI and X eI , respectively). The corresponding tidal changes in Zrs were calculated as ΔR=R eE R eI and ΔX=X eE X eI as well as their values normalised by tidal volume (V T ).…”

Section: Methodsmentioning

confidence: 99%

Pulmonary sequelae in 2-year-old children after hospitalisation for respiratory syncytial virus lower respiratory tract infection during infancy: an observational study

et al. 2023

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BackgroundRespiratory syncytial virus (RSV) is the most common cause of hospitalisation for lower respiratory tract infection (LRTI) in children. RSV LRTI during early childhood may increase susceptibility to recurrent wheezing and asthma.Research questionThe aim of this study was to describe the pulmonary sequelae at 1 and 2 years of age following RSV LRTI hospitalisation during the first year of life in term infants.Study design and methodsA longitudinal case–control study was undertaken from April 2016 to December 2019. Cases constituted children hospitalised with PCR-confirmed RSV LRTI during infancy and controls were children not previously hospitalised with LRTI. A questionnaire detailing environmental and medical history, as well as a modified International Study of Asthma and Allergies (ISAAC) questionnaire, was administered, and pulmonary function testing, including oscillometry, tidal breath flow-volume loops and multiple breath wash-out, was performed, at one and two years of age.ResultsOne (n=308) and two-year-old (n=214) cases were more likely than one (n=292) and two-year-old (n=209) controls to have experienced clinical pulmonary symptoms, including wheezing ((55% vs 24%; p<0.001) and (61% vs 16%; p<0.001)), received treatment for wheezing ((17 vs 8%; p<0.001) and (51 vs 6%; p<0.001)) and had any admissions for wheezing ((31 vs 6%; p<0.001) and (46 vs 1.4%; p<0.001)) or any LRTI ((24 vs 2%; p<0.001) and (32 vs 1.4%; p<0.001)), after the initial RSV hospitalisation. RSV LRTI during infancy was associated with an increase in airway resistance by two years (22.46 vs 20.76 hPa.s.l-1(p=0.022)), along with a decrease in compliance at both one (−4.61 vs −3.09 hPa.s/l (p<0.001)) and two years (−0.99 vs 0.33 hPa.s/l1(p<0.001)). There was an increased work of breathing at one year, but this was no longer present at two years.InterpretationRSV LRTI during infancy in cases was associated with more clinical and pulmonary function sequelae through to two years of age.

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“…However, intra-breath measurement of respiratory mechanics has been proven to help identify such phenomena as airway obstruction, expiratory flow limitation, and mechanical heterogeneity in both children and adults (111,(201)(202)(203)(204). In addition, improved ability of intrabreath oscillometry to detect changes in airway tone in children compared to classic oscillometry as well as to predict the risk of respiratory infection in early life has been shown in previous studies (110,205,206). At the time the study was instituted, preliminary intra-breath analysis was performed.…”

Section: Univariable Multivariablementioning

confidence: 97%

Oscillometry to Assess Respiratory Function in Adult Cystic Fibrosis

Rad

Landry

Dong

et al. 2020

B30. Arthur Dubois Memorial Session: The Small and Large of Airway and Lung Function

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Oscillometry to Assess Respiratory Function in Adult Cystic FibrosisBackground and Rationale: Cystic fibrosis (CF) is a life-limiting multi-system disorder in which respiratory dysfunction predominates. Although spirometry is the most commonly used test of pulmonary function, it has recognized limitations. Oscillometry is an alternative test of respiratory function which provides complementary information. Oscillometry also offers a number of practical and physiological advantages and is increasingly used in both clinical research and patient care. Surprisingly, little data exists using oscillometry to evaluate lung function in adults with CF.Accordingly, the aim of this study was to compare spirometry and oscillometry in a large adult CF cohort. Methods: Spirometry and oscillometry (tremoFlo® C-100, Thorasys Thoracic Medical Systems Inc., Montreal, Canada) were performed according to published guidelines during a routine visit to the Montreal Chest Institute Adult CF Clinic, McGill University Health Centre in 92 adults with established CF in stable state (mean age = 33.0 ± SE 1.3 yrs, 51 men). Oscillometry parameters included respiratory resistance at 5 Hz (R5), the difference in respiratory resistance at 5 and 20 Hz (R5-20), respiratory reactance at 5 Hz (X5), respiratory reactance area (AX), and resonant frequency (Fres).Results: Respiratory function was significantly reduced for the group (forced expiratory volume in one second, FEV1 = 2.27 ± SE 0.1 L; Z score = -3.38 ± SE 0.23). There was generally a good to strong correlation between spirometry and oscillometry parameters, particularly between FEV1 and both X5 and AX, and all relationships were highly significant (P < 0.001). Results were generally similar when expressed as absolute values or Z scores. Logistic regression and marginal

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Respiratory Oscillometry in Newborn Infants: Conventional and Intra-Breath Approaches

Cited by 4 publications

References 39 publications

Normal values of respiratory oscillometry in South African children and adolescents

Normal values of respiratory oscillometry in South African children and adolescents

Pulmonary sequelae in 2-year-old children after hospitalisation for respiratory syncytial virus lower respiratory tract infection during infancy: an observational study

Oscillometry to Assess Respiratory Function in Adult Cystic Fibrosis

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