Respiratory Nasal Mucosa in Chronic Rhinosinusitis with Nasal Polyps versus COVID-19: Histopathology, Electron Microscopy Analysis and Assessing of Tissue Interleukin-33

Jeican, Ionuț Isaia; Gheban, Dan; Barbu–Tudoran, Lucian; Inișca, Patricia; Albu, Camelia; Ilieș, Maria; Albu, Silviu; Vică, Mihaela Laura; Matei, Horea; Tripon, Septimiu; Lazăr, Mihaela; Aluaș, Maria; Siserman, Costel Vasile; Muntean, Monica; Trombitaș, Veronica; Iuga, Cristina; Opincariu, Iulian; Junie, Lia Monica

doi:10.3390/jcm10184110

Cited by 12 publications

(6 citation statements)

References 85 publications

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“…Moreover, IL-33 can act as a differentiating marker. For instance, compared to COVID-19 patients, a higher concentration of IL-33 was detected in the nasal mucosa of chronic rhinosinusitis with nasal polyps (CRSwNP) patients, which can be explained by its chronic course [ 215 ]. In addition, postmortem lung tissues of COVID-19 patients were depleted of IL-33 and AEC2 compared to those of the healthy subjects and patients with COPD or IPF [ 184 ].…”

Section: Il-33 and Covid-19mentioning

confidence: 99%

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

et al. 2022

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A global pandemic has erupted as a result of the new brand coronavirus, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This pandemic has been consociated with widespread mortality worldwide. The antiviral immune response is an imperative factor in confronting the recent coronavirus disease 2019 (COVID-19) infections. Meantime, cytokines recognize as crucial components in guiding the appropriate immune pathways in the restraining and eradication of the virus. Moreover, SARS-CoV-2 can induce uncontrolled inflammatory responses characterized by hyper-inflammatory cytokine production, which causes cytokine storm and acute respiratory distress syndrome (ARDS). As excessive inflammatory responses are contributed to the severe stage of the COVID-19 disease, therefore, the pro-inflammatory cytokines are regarded as the Achilles heel during COVID-19 infection. Among these cytokines, interleukin (IL-) 1 family cytokines (IL-1, IL-18, IL-33, IL-36, IL-37, and IL-38) appear to have a strong inflammatory role in severe COVID-19. Hence, understanding the underlying inflammatory mechanism of these cytokines during infection is critical for reducing the symptoms and severity of the disease. Here, the possible mechanisms and pathways involved in inflammatory immune responses are discussed.

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Section: Il-33 and Covid-19mentioning

confidence: 99%

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

et al. 2022

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“…In patients presenting with CRSwNP, a confirmation of this diagnosis has to be firstly assessed by ENT specialist considering several parameters, as indicated in Figure 6, point a. As suggested by recent position papers, the evidence of type-2 inflammation should be high likely in these patients and for this reason, searching for local or systemic eosinophils and IgE count is advised [11,47,48] Considering that other biomarkers currently used to define type-2 disease are blood eosinophilia, IgE levels, EPOS group suggested specific cut offs for the following biomarkers: >250/µL for blood eosinophilia and >100 kU/L for total IgE [1,12].…”

Section: Patient With Severe Crswnp At the Ent Unit Complaining About...mentioning

confidence: 99%

“…In particular, primary CRS is characterized by both type-2 and non-type-2 endotype, while pathological processes (e.g., inflammatory, mechanical or immunological) are at the basis of secondary CRS [ 10 ]. Interestingly, a recent study compared modifications of the nasal mucosa in both COVID-19 and CRSwNP patients and showed a different tissue interleukin IL-33 concentration, resulting higher in CRSwNP subjects thus suggesting a different inflammatory pattern [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Management of Patients with Severe Asthma and Chronic Rhinosinusitis with Nasal Polyps: A Multidisciplinary Shared Approach

Seccia

D’Amato

Scioscia

et al. 2022

JPM

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Chronic rhinosinusitis (CRS) is one of the most frequent comorbidities associated with asthma and it contributes to an amplified global disease burden in asthmatics. CRS prevalence is much higher in asthmatic patients compared to the general population and it is more frequently related to severe asthma, especially in presence of nasal polyps (chronic rhinosinusitis with nasal polyps, CRSwNP). Moreover, asthma exacerbation has a higher occurrence in CRSwNP. From a pathologic point of view, CRS and asthma share similar and connected mechanisms (e.g., type-2 inflammation). A multidisciplinary approach represents a crucial aspect for the optimal management of patients with concomitant asthma and CRSwNP and improvement of patient quality of life. An Italian panel of clinicians with different clinical expertise (pulmonologists, ear, nose and throat specialists, immunologists and allergy physicians) identified three different profiles of patients with coexisting asthma and nasal symptoms and discussed the specific tracks to guide a comprehensive approach to their diagnostic and therapeutic management. Currently available biological agents for the treatment of severe asthma act either on eosinophil-centered signaling network or type-2 inflammation, resulting to be effective also in CRSwNP and representing a valid option for patients with concomitant conditions.

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“…Although hormonal changes are thought to be the cause of pregnancy-induced rhinitis, the specific pathophysiology of hormonal rhinitis is still unknown, and smoking seems to be the only known risk factor [1,9,15]. PIR was not linked to either hay fever or asthma [6,8,10].…”

Section: Description Of the State Of Knowledgementioning

confidence: 95%

Pregnancy-induced rhinitis: nose problems at the obstetrician's office

Standyło

Obuchowska

et al. 2022

J Educ Health Sport

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Introduction and purpose Pregnancy-induced rhinitis (PIR) manifests as nasal congestion, with resolution of symptoms after delivery. Pregnancy-induced rhinitis is a distinct condition from allergic rhinitis, it may not respond to treatment for allergic rhinitis. The first stage in providing adequate and effective management of PIR is to have a clear and appropriate diagnosis. Therefore, each patient-specific management of PIR must take careful consideration of a variety of circumstances. The aim of this study was to conduct a literature review on pregnancy-induced rhinitis. A literature review was carried out in the PubMed, MEDLINE, and Scopus databases using the terms ‘rhinitis and pregnancy’. Brief description of the state of knowledge Physiological factors underlying PIR are not well understood at the moment. There is no single explanation for the pathophysiological mechanism that would account for the changes in PIR. Nasal congestion is the primary nasal symptom in pregnancy-induced rhinitis. It can result in night-time mouth breathing and poor sleep quality. The mother's sleep may be negatively impacted by nasal congestion resulting in maternal hypertension, pre-eclampsia, and intrauterine growth retardation. Increasing awareness not only benefits pregnant patients' quality of life but also has a favourable impact on how a pregnancy turns out. Summary PIR has gained relevance in recent years due to its major effects on maternal quality of life as well as the identification of a relationship with OSAS in the mother and potential harmful consequences on the foetus. The mother's quality of life is significantly impacted by PIR, as shown, thus both the otorhinolaryngologist and the obstetrician must use caution in the early identification and treatment of pregnancy-induced rhinitis.

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Respiratory Nasal Mucosa in Chronic Rhinosinusitis with Nasal Polyps versus COVID-19: Histopathology, Electron Microscopy Analysis and Assessing of Tissue Interleukin-33

Cited by 12 publications

References 85 publications

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

The role of IL-1 family of cytokines and receptors in pathogenesis of COVID-19

Management of Patients with Severe Asthma and Chronic Rhinosinusitis with Nasal Polyps: A Multidisciplinary Shared Approach

Pregnancy-induced rhinitis: nose problems at the obstetrician's office

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