Respiratory muscle weakness in peripheral neuropathies

Burakgazi, Ahmet Z.; Höke, Ahmet

doi:10.1111/j.1529-8027.2010.00293.x

Cited by 31 publications

(19 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Reports of respiratory dysfunction such as diaphragmatic weakness have been described in individuals with the CMT disease [9,10]. Sensory hearing loss can also occur [11,12] and also paresis of the vocal cords, which may be associated with a more severe variant of the disease [8].…”

Section: Introductionmentioning

confidence: 99%

Evaluation of Respiratory Muscle Strength and Pulmonary Function in Patients with Charcot-Marie-Tooth Disease Type 2

Garcez

Neves²,

Melo³

et al. 2015

Eur Neurol

View full text Add to dashboard Cite

The aim of this study was to evaluate the pulmonary condition in a large family with Charcot-Marie-Tooth disease type 2 (CMT2). Eighteen participants diagnosed with CMT2 and 20 healthy individuals were evaluated by spirometry and maximal expiratory and maximal inspiratory pressures (MEP and MIP, respectively). Clinical disability was measured with CMT neuropathy score (CMTNS; range 0-36). One control group (CG) comprising 20 individuals, matched for age, sex and body mass index, were used for comparison. Eight patients were female (44.5%) and 10 patients were male (55.5%); mean age was 31.8 years (range 11-79) and CMTNS range was 6-26. Differences between CMT2 and CG in the spirometry and respiratory muscle strength were statistically significant for all dimensions. There were significant correlations between CMTNS and MIP (Pearson = -0.581) and MEP (Pearson = -0.5090). The results of this study show that patients with CMT, in spite of not showing clinical signs of advanced respiratory impairment, may present subclinical respiratory changes. The respiratory comprise in the CMT disease can be silent and insidious without presenting characteristic clinical signals.

show abstract

Section: Introductionmentioning

confidence: 99%

Evaluation of Respiratory Muscle Strength and Pulmonary Function in Patients with Charcot-Marie-Tooth Disease Type 2

Garcez

Neves²,

Melo³

et al. 2015

Eur Neurol

View full text Add to dashboard Cite

show abstract

“…The most common hereditary PN is Charcot-Marie-Tooth (CMT) disease. 44,64 ANS dysfunctions including reduced sweating, bladder dysfunction, impotence, fluctuations in blood temperature and BP, and repeated vomiting can be seen in hereditary sensory and autonomic neuropathies. 65 However, there is no clear information on prevalence and clinic features on cardiac involvement in hereditary peripheral neuropathy including CMT and hereditary sensory and autonomic neuropathies.…”

Section: Hereditary Peripheral Neuropathymentioning

confidence: 98%

“…[42][43][44] Acute inflammatory demyelinating polyradiculoneuropathy (AIDP) is the most common subtype of GBS and accounts for around 90% of GBS cases in North America and Europe, whereas acute motor axonal neuropathy only accounts for approximately 5%-10% of GBS cases. 42,43 The distribution of subtypes shows wide variation in different regions, for example, 30%-47% of GBS cases are the axonal form in Asia, and South and Central America.…”

Section: Gbs Introductionmentioning

confidence: 99%

Cardiac Involvement in Peripheral Neuropathies

Burakgazi

Almahameed

2016

Journal of Clinical Neuromuscular Disease

Self Cite

View full text Add to dashboard Cite

Cardiac autonomic neuropathy (CAN) is the least recognized and understood complication of peripheral neuropathy. However, because of its potential adverse effects including sudden death, CAN is one of the most important forms of autonomic neuropathies. CAN presents with different clinical manifestations including postural hypotension, exercise intolerance, fluctuation of blood pressure and heart rate, arrhythmia, and increased risk of myocardial infarction. In this article, the prevalence, clinical presentations, and management of cardiac involvement in certain peripheral neuropathies, including diabetic neuropathy, Guillain-Barré syndrome, chronic inflammatory polyneuropathy, human immunodeficiency virus-associated neuropathy, hereditary neuropathies, and amyloid neuropathy are examined in detail.

show abstract

“…In general, if the forced vital capacity is less than 15-20 mL/kg, the maximum expiratory pressure is less than 30 cmH 2 O and the maximum inspiratory pressure is less than 30 cmH 2 O, impending respiratory arrest is present and intubation should be performed [ 148 ] . Also, PCO 2 above 48 mmHg or PO 2 less than 56 mmHg on room air are de fi nite indications for intubation [ 2,149 ] .…”

Section: Supportive Carementioning

confidence: 99%