Respiratory Muscle Weakness during Upper Respiratory Tract Infections

Abstract

Global respiratory muscle strength was studied in 22 normal healthy volunteers during a 4-month winter period. Twelve subjects developed naturally acquired upper respiratory tract infections. Maximal static expiratory and inspiratory mouth pressures fell significantly during these infections. The greatest falls were documented between the third and seventh days of clinical illness. Full recovery occurred by the fourteenth day. We conclude that significant abnormalities of respiratory muscle function can occur during upper respiratory tract infections in otherwise healthy young adults.

Successful weaning from mechanical ventilation in the quadriplegia patient with C2 spinal cord injury undergoing C2-4 spine laminoplasty -A case report-

“…Adequate expiratory muscle function is critical for clearing airway secretions and bronchial mucous plugs. During periods of respiratory tract infection (RTI) or profuse airway secretion, peak cough expiratory flows (PCEFs) must be adequate to prevent mucous plugging and pulmonary complications [10]. The VC, FVC, and PCEF are decreased during RTIs because of fatigue, respiratory musculature weakening, and mucous plugging [10].…”

“…During periods of respiratory tract infection (RTI) or profuse airway secretion, peak cough expiratory flows (PCEFs) must be adequate to prevent mucous plugging and pulmonary complications [10]. The VC, FVC, and PCEF are decreased during RTIs because of fatigue, respiratory musculature weakening, and mucous plugging [10]. When inadequate, the most effective alternative for generating optimal PCEF and clearing deep airway secretions is the use of mechanical insufflation-exsufflation (MI-E) [11].…”

Comparação entre parâmetros de pressões respiratórias máximas em indivíduos saudáveis

“…After one of the researchers had personally contacted the individuals who were interested in participating in the study, those who met the inclusion criteria were invited to undergo testing, the study sample being therefore a convenience sample. The exclusion criteria were as follows: being a current smoker; being obese, obesity having been defined as a body mass index (BMI) ≥ 30 kg/m 2 ; being underweight, malnutrition having been defined as a BMI < 18.5 kg/m 2(16) ; having had upper airway infection in the two weeks preceding data collection (17,18) ; having reported a diagnosis of lung, cardiovascular, or neuromuscular disease (3) ; and continuously using oral/inhaled corticosteroids or any other medication that could interfere with skeletal muscle contractility. (19) The present study was approved by the Human Research Ethics Committee of the Federal University of Juiz de Fora University Hospital (Ruling no.…”

Critical diaphragm failure in sudden infant death syndrome

“…In a study on human adults with routine upper respiratory tract infection, diaphragm strength fell significantly ( P < 0.01), with the largest decline occurring between days 3 and 7 of clinical illness (53). Full recovery of respiratory pressure took place by day 14.…”

“…Animal studies have shown that non-lethal sepsis induced by either Streptococcus pneumoniae or E. coli with no change in blood pressure, serum electrolytes, or acid status caused a significant impairment of diaphragm function (52). In human adults, Mier-Jedrzejowicz and co-workers observed already in 1988 that pulmonary function can deteriorate significantly ( P < 0.05) after even apparently mild respiratory infections (53). In patients with vulnerable respiratory systems, routine infections have been shown to result in shortness of breath, reduction in vital capacity, and acute hypercapnia (49).…”