Respiratory muscle strength and the risk of incident cardiovascular events

Palen, Job van der

doi:10.1136/thx.2004.021915

Cited by 87 publications

(63 citation statements)

References 23 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…When compared to respiratory muscle strength with the predicted by the equation of Neder et al [8], there was statistical difference only for MEP data which differ from those of van der Palen et al [18], who found decreased muscle strength in patients with acute myocardial infarction, considering it as an independent risk factor. One possible reason to explain this finding is that in our studied sample we included patients with valve and aortic disease, which may have a positive effect on the values of respiratory muscle strength.…”

Section: Discussionmentioning

confidence: 65%

Relação do comportamento da força muscular com as complicações respiratórias na cirurgia cardíaca

Riedi¹,

Mora²,

Driessen³

et al. 2010

Rev Bras Cir Cardiovasc

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 65%

Relação do comportamento da força muscular com as complicações respiratórias na cirurgia cardíaca

Riedi¹,

Mora²,

Driessen³

et al. 2010

Rev Bras Cir Cardiovasc

View full text Add to dashboard Cite

“…Hence, participants who were characterized as "without airflow obstruction" may have included those with a reduced FVC, a consequence of normal aging or restrictive pattern. A reduced FVC has been shown to be a strong predictor of cardiovascular events and mortality (45,46), and may have confounded the association between CT-measured emphysema and mortality.…”

Section: Discussionmentioning

confidence: 99%

Phenotype of Normal Spirometry in an Aging Population

Fragoso

McAvay

Ness

et al. 2015

Am J Respir Crit Care Med

View full text Add to dashboard Cite

Rationale: In aging populations, the commonly used Global Initiative for Chronic Obstructive Lung Disease (GOLD) may misclassify normal spirometry as respiratory impairment (airflow obstruction and restrictive pattern), including the presumption of respiratory disease (chronic obstructive pulmonary disease [COPD]).Objectives: To evaluate the phenotype of normal spirometry as defined by a new approach from the Global Lung Initiative (GLI), overall and across GOLD spirometric categories.Methods: Using data from COPDGene (n = 10,131; ages 45-81; smoking history, >10 pack-years), we evaluated spirometry and multiple phenotypes, including dyspnea severity (Modified Medical Research Council grade 0-4), health-related quality of life (St. George's Respiratory Questionnaire total score), 6-minute-walk distance, bronchodilator reversibility (FEV 1 % change), computed tomography-measured percentage of lung with emphysema (% emphysema) and gas trapping (% gas trapping), and small airway dimensions (square root of the wall area for a standardized airway with an internal perimeter of 10 mm).Measurements and Main Results: Among 5,100 participants with GLI-defined normal spirometry, GOLD identified respiratory impairment in 1,146 (22.5%), including a restrictive pattern in 464 (9.1%), mild COPD in 380 (7.5%), moderate COPD in 302 (5.9%), and severe COPD in none. Overall, the phenotype of GLI-defined normal spirometry included normal adjusted mean values for dyspnea grade (0.8), St. George's Respiratory Questionnaire (15.9), 6-minute-walk distance (1,424 ft [434 m]), bronchodilator reversibility (2.7%), % emphysema (0.9%), % gas trapping (10.7%), and square root of the wall area for a standardized airway with an internal perimeter of 10 mm (3.65 mm); corresponding 95% confidence intervals were similarly normal. These phenotypes remained normal for GLI-defined normal spirometry across GOLD spirometric categories.Conclusions: GLI-defined normal spirometry, even when classified as respiratory impairment by GOLD, included adjusted mean values in the normal range for multiple phenotypes. These results suggest that among adults with GLI-defined normal spirometry, GOLD may misclassify normal phenotypes as having respiratory impairment.

show abstract

“…The best value of 3 recordings was used. The FEV 1 and FVC values are expressed as percentages of the predicted values, adjusted for age, gender, and height. The predicted values were those of the European Community of Coal and Steel approved by the European Respiratory Society.…”

Section: Spirometric Functionmentioning

confidence: 99%

“…1 Moreover, hypercapnic respiratory failure caused by inspiratory muscle weakness has been recognized as the leading cause of death among COPD patients. 2 Determining inspiratory muscle strength is therefore useful in evaluating strategies over preventive and therapeutic approaches for improving respiratory muscle strength.…”

Section: Introductionmentioning

confidence: 99%

Twitch Mouth Pressure and Disease Severity in Subjects With COPD

2013

View full text Add to dashboard Cite

INTRODUCTION:Patients with COPD have impaired respiratory muscle strength. Twitch mouth pressure (P tw,m ) in response to magnetic stimulation of the cervical nerve has been suggested to clinically reflect inspiratory muscle strength. However, studies on P tw,m values and their relationship with disease severity are limited. Thus, we tested the P tw,m values of subjects with COPD and investigated the relationship of these values with disease severity. METHODS: We recruited 75 COPD patients and 63 age-matched controls. All participants were tested for P tw,m , sniff nasal pressure (SNIP), and maximum static inspiratory mouth pressure (P I max ); the BODE (body mass index, air flow obstruction, dyspnea, exercise capacity) index was evaluated for overall severity assessment and the 6-min walk distance (6MWD) was used to determine the exercise capacity of subjects with COPD. RESULTS: Subjects with COPD had markedly lower P tw,m values compared with the controls (10.00 ؎ 2.17 vs 13.66 ؎ 2.20 cm H 2 O for males, 8.83 ؎ 0.89 vs 11.81 ؎ 1.98 cm H 2 O for female; each with P < .001). The P tw,m values decreased with increasing COPD severity, and similar trends were observed in the SNIP and P I max values. Regression correlation analysis showed that P tw,m values were significantly correlated inversely with the BODE index (R ‫؍‬ 0.65, P < .001) but positively correlated with 6MWD (R ‫؍‬ 0.59, P < .001) in the COPD group; the SNIP values of subjects with COPD were also correlated inversely with their BODE index (R ‫؍‬ 0.49, P < .001) but positively correlated with their 6MWD (R ‫؍‬ 0.33, P < .005). CONCLUSIONS: P tw,m values are 26.8% lower in male subjects with COPD and 25.3% lower in female subjects with COPD compared with the controls. The P tw,m values of subjects with COPD decrease with increasing disease severity. P tw,m was better correlated with the BODE index and exercise capacity than SNIP and P I max , which suggests that P tw,m more accurately reflects the overall severity and burden of COPD.

show abstract

Respiratory muscle strength and the risk of incident cardiovascular events

Cited by 87 publications

References 23 publications

Relação do comportamento da força muscular com as complicações respiratórias na cirurgia cardíaca

Relação do comportamento da força muscular com as complicações respiratórias na cirurgia cardíaca

Phenotype of Normal Spirometry in an Aging Population

Twitch Mouth Pressure and Disease Severity in Subjects With COPD

Contact Info

Product

Resources

About