The respiratory muscles have been studied extensively during the last 20 yrs. This interest was triggered predominantly by the observation made by ROUSSOS and MACKLEM [1] that the respiratory muscles, like all other skeletal muscles, may fatigue. Subsequent research critically examined the significance of inspiratory muscle fatigue in clinical pulmonary medicine. The conclusion of this research was largely that inspiratory muscle fatigue was rarely, if ever, present [2,3]. Respiratory muscle fatigue appeared to be effectively avoided by reduction of the duration of inspiration whenever the limits of respiratory muscle performance were approached [4]. This reduction in the duration of inspiration leads to an inappropriately small tidal volume, and, hence, to alveolar hypoventilation and consequent hypercapnia [4,5]. Inspiratory muscle fatigue, therefore, appeared to occur only in exceptional circumstances, such as cardiogenic [6] or septic shock [7] and weaning from mechanical ventilation [8]. The limits of respiratory muscle performance are determined by respiratory muscle force and endurance capacity. At present, there are few data on the clinical significance of respiratory muscle endurance. There are, however, abundant data on respiratory muscle weakness.Indeed, the clinical significance of respiratory muscle weakness is now clearly established, not only conceptually (see above), but also through empirical observation. Although there are, without question, other circumstances in which it is important, it has been most extensively studied in patients with chronic obstructive pulmonary disease (COPD). The present Editorial, therefore, will focus primarily on COPD. Inspiratory muscle weakness was shown to be related to dyspnoea [9], fatigue, and exercise limitation in COPD patients [10]. Expiratory muscle weakness was shown to be related to cough efficiency [11,12]. In addition, inspiratory muscle weakness is an important determinant of the development of hypercapnic respiratory failure [13]. As hypercapnic respiratory failure is the most important cause of death in COPD [14], inspiratory muscle weakness is, therefore, also expected to be related to mortality in these patients. At least two observations support the presence of such a relationship. Indeed, DECRAMER et al. [15] demonstrated that survival was severely reduced in patients with COPD and steroidinduced myopathy in comparison to control COPD patients, despite the fact that they had the same degree of airflow obstruction and hyperinflation, the known major determinants of survival in COPD. Moreover, , in a cohort study on 348 COPD patients, demonstrated that, in hospitalized COPD patients, maximal inspiratory pressure (PI,max) was an independent determinant of survival, besides hypercapnia, body mass index and transfer factor.There are numerous factors potentially contributing to respiratory muscle weakness in COPD patients. Inspiratory muscle weakness may be related to hyperinflation, which puts the inspiratory muscles at a less advantageous positio...