Respiratory morbidity, atopy and asthma at school age in preterm infants aged 32–35 weeks

Morata-Alba, Júlia; Romero-Rubio, Maria Teresa; Castillo‐Corullón, Silvia; Escribano-Montaner, Amparo

doi:10.1007/s00431-019-03372-1

Cited by 31 publications

(62 citation statements)

References 45 publications

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“…A family history of allergies was also an important risk factor for wheezing in children [25]. The results of this study showed that a family history of allergies was a risk factor for early wheezing in preterm infants with a GA > 32 weeks but < 37 weeks, which was consistent with previous ndings [24].…”

Section: Discussionsupporting

confidence: 92%

Risk factors for early wheezing in preterm infants: a retrospective cohort study

Chen

Yang²,

Huang

et al. 2020

Preprint

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Background: The factors that cause recurrent wheezing in children are complex, and premature delivery may be one of these factors. Little is known about early wheezing in preterm infants.Methods: Data were sourced from 1616 children born between 2007 and 2013 from 8 hospitals in Guangxi, China. All children were followed up by telephone or questionnaire through the sixth year of life. Children were grouped by gestational age (GA): Group A, GA ≤ 32 weeks; Group B, 32 weeks < GA < 37 weeks; and Group C, 37 weeks ≤ GA < 42 weeks.Results: The incidences and risk factors for early wheezing in preterm infants were analysed. The incidences of early wheezing were as follows: Group A > Group B > Group C. The incidence of persistent early wheezing in Group A or Group B was significantly higher than that in Group C, respectively. SGA (95% CI: 1.097 to 7.519) was a risk factor for early wheezing in group A. Male sex (95% CI: 1.595 to 4.501) and family history of allergies (95% CI: 1.207 to 3.352) were risk factors for early wheezing in group B.Conclusions: 1. New-borns with younger GAs had a higher risk of early wheezing. 2. The incidence of persistent early wheezing for preterm infants (GA ≤ 32 weeks and 32 weeks < GA < 37 weeks) was higher than that for full-term infants (37 weeks ≤ GA < 42 weeks). 3. SGA was a risk factor for early wheezing in preterm infants with a GA ≤ 32 weeks. 4. Male sex, personal history of allergies and family history of allergies were all possible factors affecting early wheezing in preterm infants with a GA > 32 weeks but < 37 weeks and full-term infants. Among them, male sex and family history of allergies were risk factors for early wheezing. 5. Mode of delivery, passive smoking, breastfeeding and invasive mechanical ventilation were not possible risk factors for early wheezing in infants of different GAs.

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Section: Discussionsupporting

confidence: 92%

Risk factors for early wheezing in preterm infants: a retrospective cohort study

Chen

Yang²,

Huang

et al. 2020

Preprint

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“…However, personal history of allergy did not show a signi cant difference in early wheezing in preterm infants with GA ≤ 32 weeks, suggesting that personal history of allergy might not be associated with early wheezing in preterm infants with GA ≤ 32 weeks. Family history of allergy was also an important risk factor for wheezing in children [25]. The result of this study showed that family history of allergy was a risk factor for early wheezing in preterm infants with 32 weeks < GA < 37 weeks, which was consistent with previous ndings [24].…”

Section: Discussionsupporting

confidence: 92%

Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

Chen

Yang²,

Huang

et al. 2020

Preprint

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Background: The related factors that cause recurrent wheezing in children are complex, and premature delivery may be one of the reasons. Little is known about early wheezing in preterm infants. Methods: Data sourced from 1616 children born between 2007 and 2013 from 8 hospitals of Guangxi in China. All children were followed by telephone or questionnaire through the sixth year of life. Children were grouped by characters of age: Group A: gestational age (GA) ≤ 32 weeks, Group B: 32 weeks < GA < 37 weeks, Group C: 37 weeks ≤ GA < 42 weeks. Results: The incidence and the risk factors of early wheezing in preterm infants were analyzed. The incidence of early wheezing: Group A > Group B > Group C. In Group A, the proportion of small-for-gestational-age (SGA) infant was higher in early wheezing group than in normal group (P = 0.005). Male (95% CI: 1.611 to 4.601) and family history of allergy (95% CI: 1.222 to 3.411) were the risk factors for early wheezing in Group B. Conclusions: Newborns with younger GA had a higher risk of early wheezing. SGA was a possible factor influencing early wheezing in preterm infants with GA≤ 32 weeks. Male and family history of allergy were the risk factors for early wheezing in preterm infants with 32 weeks < GA < 37 weeks.

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“…Very and extremely preterm babies are the most likely to be affected as they were born at such a vulnerable period. Nevertheless, moderately-late preterm constitute the main group of preterm babies nowadays and recent evidence suggests more long-term morbidities than term-born babies 2,3 .…”

mentioning

confidence: 99%

Asthma prevalence, lung and cardiovascular function in adolescents born preterm

Arroyas

Calvo

Rueda

et al. 2020

Sci Rep

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Our main objective was to study respiratory evolution and pulmonary and cardiac function in adolescents born preterm in the post-surfactant era. Observational cross-sectional study, comparing very preterm (< 32 weeks) and moderately-late preterm adolescents (≥ 32 weeks) (74 each group). We recorded respiratory symptoms, spirometry and functional echocardiogram. Very preterm adolescents required more respiratory admissions (45.9% vs. 28.4%) (p = 0.03, OR 2.1, CI95% 1.1–4.2) and had more current asthma (21.6% vs. 9.5%, p = 0.04, OR 2.3, CI95% 1.1–5.2). Preterm subjects with intrauterine growth restriction (IUGR) presented lower FEV1 (88.7 ± 13.9 vs. 95.9 ± 13.3, p = 0.027) and lower FVC (88.2 ± 13.6 vs. 95.5 ± 13.3, p = 0.025). When assessing right ventricle, very preterm showed a greater E/E’ ratio (p = 0.02) and longer myocardial performance index (MPI) (p = 0.001). Adolescents with IUGR showed less shortening fraction (p = 0.016), worse E/E′ ratio (p = 0.029) and longer MPI (p = 0.06). Regarding left ventricle, very preterm showed less E′ wave velocity (p = 0.03), greater E/E′ ratio (p = 0.005) and longer MPI (p < 0.001). Gestational age < 32 weeks is independently associated with current asthma in adolescence. Children 13–14 years old born very preterm required more respiratory admissions and had poorer diastolic and global function of both ventricles. IUGR is a risk factor for poorer lung function in preterm adolescents, regardless gestational age.

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Respiratory morbidity, atopy and asthma at school age in preterm infants aged 32–35 weeks

Cited by 31 publications

References 45 publications

Risk factors for early wheezing in preterm infants: a retrospective cohort study

Risk factors for early wheezing in preterm infants: a retrospective cohort study

Risk Factors for Early Wheezing in Preterm Infants: A Retrospective Cohort Study

Asthma prevalence, lung and cardiovascular function in adolescents born preterm

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