Respiratory morbidity 20 years after RSV infection in infancy

Korppi, Matti; Piippo-Savolainen, Eija; Korhonen, Kaj; Remes, Sami

doi:10.1002/ppul.20058

Cited by 143 publications

(144 citation statements)

References 29 publications

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“…Although the underlying mechanisms whereby reduced Crs leads to RSV hospitalisation are unknown, it is possible that reduced Crs reflects differences in lung characteristics leading to both a severe RSV infection and childhood asthma. Several prospective studies have described the association between RSV bronchiolitis and the development of post-bronchiolitis wheeze [28][29][30]. Our data suggest that besides the severity of the RSV infection, premorbid increased Rrs and decreased Crs also are independent determinants of post-RSV wheeze.…”

Section: Discussionsupporting

confidence: 54%

Decreased lung function precedes severe respiratory syncytial virus infection and post-respiratory syncytial virus wheeze in term infants

Zomer-Kooijker

Uiterwaal

Gugten

et al. 2014

European Respiratory Journal

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It is unknown why respiratory syncytial virus (RSV) causes mild disease in some children and severe disease, requiring hospitalisation, in others. We aimed to assess whether diminished premorbid lung function in healthy term infants predisposes to hospitalisation during RSV bronchiolitis, and to post-RSV wheeze.In a prospective birth cohort study of unselected term healthy children, neonatal lung function was measured before the age of 2 months (n52133). From birth through the first year of life, respiratory symptoms were recorded in a diary, and general practitioner consultations and hospitalisations were documented. In a subgroup (n5417) repeated nose and throat swabs were collected for PCR to detect RSV infections.Median neonatal respiratory system compliance (Crs) was significantly lower (41.2 versus 47.4 mL?kPa -1 , p50.03) and resistance (Rrs) was higher (8.2 versus 6.3 kPa?s?L -1 , p50.10) in hospitalised RSV patients (n518) compared with nonhospitalised RSV-positive infants (n584). Every 10 mL?kPa -1 increase in Crs was associated with 55% less post-RSV wheeze (OR 0.56, 95% CI 0.35-0.90), and each kPa?s?L -1 increase in Rrs was associated with 42% more post-RSV wheeze, which was only marginally explained by pre-RSV wheeze or severity of the RSV disease.This unselected birth cohort study shows for the first time that decreased lung function at birth predisposes to severe RSV disease, and to post-RSV wheeze. @ERSpublications Impaired neonatal lung function precedes a severe course of RSV infection in unselected children

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Section: Discussionsupporting

confidence: 54%

Decreased lung function precedes severe respiratory syncytial virus infection and post-respiratory syncytial virus wheeze in term infants

Zomer-Kooijker

Uiterwaal

Gugten

et al. 2014

European Respiratory Journal

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“…They comprised 6 birth cohorts [17][18][19][20][21][22] and 19 population-based longitudinal studies. [12,13,[23][24][25][26][27][28][29][30][31][32][33][34][35][36][37][38][39] Tables 1 and 2 give an overview of the included studies. The reasons for rejecting the remaining 30 papers [9,10, are summarised in Table 3.…”

Section: Resultsmentioning

confidence: 99%

A systematic review of early life factors which adversely affect subsequent lung function

Kouzouna

Gilchrist

Ball

et al. 2016

Paediatric Respiratory Reviews

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It has been known for many years that multiple early life factors can adversely affect lung function and future respiratory health. This is the first systematic review to attempt to analyse all these factors simultaneously. We adhered to strict a priori criteria for inclusion and exclusion of studies.The initial search yielded 29,351 citations of which 208 articles were reviewed in full and 25 were included in the review. This included 6 birth cohorts and 19 longitudinal population studies. The 25 studies reported the effect of 74 childhood factors (on their own or in combinations with other factors) on subsequent lung function reported as percent predicted forced expiration in one second (FEV 1 ). The childhood factors that were associated with a significant reduction in future FEV 1 could be grouped as: early infection, bronchial hyper-reactivity (BHR) / airway lability, a diagnosis of asthma, wheeze, family history of atopy or asthma, respiratory symptoms and prematurity / low birth weight. A complete mathematical model will only be possible if the raw data from all previous studies is made available. This highlights the need for increased cooperation between researchers and the need for international consensus about the outcome measures for future longitudinal studies.

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“…Early-life exposure to such pathogens is likely to have lifelong respiratory consequences. Indeed, even in healthy term-born infants, hospitalisation with acute respiratory viruses in early life is associated with increased rates of childhood asthma, wheezing disorders and suboptimal lung function [29–31]. While preterm infants are often labelled as asthmatic, the underlying mechanisms of prematurity associated wheeze are likely to be different [32] although the long-term implications of exposure to acute respiratory viruses during early life remains to be elucidated in the preterm population.…”

Section: Preterm Birth and Bronchopulmonary Dysplasia: An Immature Symentioning

confidence: 99%

“…Early-life exposure to severe RSV infection has also been identified as a main contributor in the development of suboptimal lung health and function later in life, with several studies reporting increased risks of late-onset or persistent wheezing phenotypes, asthma diagnosis, and impaired lung function in adolescents and young adults [29–31]. Even though the majority of the data on the long-lasting impact of RSV have been based on studies of healthy term-born infants, limited studies have demonstrated increased risk of asthma [68], recurrent wheeze [34,69,70] and lung function impairments [66] in preterm children with a history of RSV-related hospitalisation during infancy.…”

Section: Viral Infection Requiring Readmission In Early Lifementioning

confidence: 99%

The impact of respiratory viruses on lung health after preterm birth

Townsi

Laing

Hall

et al. 2018

European Clinical Respiratory Journal

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Children born preterm, less than 37 weeks’ gestation, are at increased risk of viral respiratory infections and associated complications both during their initial birth hospitalisation and in their first years following discharge. This increased burden of viral respiratory infections is likely to have long term implications for lung health and function in individuals born preterm, particularly those with bronchopulmonary dysplasia. Several hypotheses have been put forward to explain the association between early life viral respiratory infection and development of suboptimal lung health and function later in life following preterm birth. Although preterm infants with diminished lung function, particularly small airways, might be particularly susceptible to asthma and wheezing disorders following viral infection, there is evidence that respiratory viruses can activate number of inflammatory and airway re-modelling pathways. Therefore, the aim of this review is to highlight the perinatal and early life risk factors that may contribute to increased susceptibility to viral respiratory infections among preterm infants during early life and to understand how respiratory viral infection may influence the development of abnormal lung health and function later in life.

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Respiratory morbidity 20 years after RSV infection in infancy

Cited by 143 publications

References 29 publications

Decreased lung function precedes severe respiratory syncytial virus infection and post-respiratory syncytial virus wheeze in term infants

Decreased lung function precedes severe respiratory syncytial virus infection and post-respiratory syncytial virus wheeze in term infants

A systematic review of early life factors which adversely affect subsequent lung function

The impact of respiratory viruses on lung health after preterm birth

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