Respiratory influence on heart rate in diabetes mellitus.

Sundkvist, Göran; Almér, Lars‐Olof; Lilja, B.

doi:10.1136/bmj.1.6168.924

Cited by 241 publications

(134 citation statements)

References 10 publications

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“…Autonomic nerve function was assessed from the heart rate reactions to deep breathing (expiration/inspiration ratio, a test of parasympathetic nerve function) [26] and to tilt (acceleration and brake indices, tests considering sympathetic nerve function as well) [27]. The blood pressure reaction to tilt was also assessed as a test of sympathetic nerve function.…”

Section: Subjects Materials and Methodsmentioning

confidence: 99%

Glutamic acid decarboxylase antibodies, autonomic nerve antibodies and autonomic neuropathy in diabetic patients

Sundkvist¹,

Velloso²,

K�mpe³

et al. 1994

Diabetologia

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SummaryTo clarify whether GAD-ab are associated with diabetic autonomic neuropathy and/or complement fixing antibodies against sympathetic ganglia, adrenal medulla, and vagus nerve, we examined 133 diabetic patients (95 with IDDM). GAD-ab were determined by a radioligand binding assay using in vitro expression of recombinant GAD-65 whereas sympathetic ganglia antibodies, adrenal medulla antibodies, vagus nerve, and ICA were evaluated by indirect immunofluorescence assays. Autonomic nerve function was evaluated by objective tests (heart rate reactions to deep breathing and to tilt). In the total material of 133 patients, GAD-ab were detected in 36 patients, all of whom had IDDM. The frequency of GADab was similar (38 %) in IDDM patients with and without signs of autonomic neuropathy (21 of 55 vs 15 of 40). In addition, there were no significant associations between GAD-ab and autonomic nerve antibodies; GAD-ab were detected in 9 of 21 (43 %) of patients with and in 27 of 112 (24 %) of patients without sympathetic ganglia antibodies, in 5 of 15 (33 %) of patients with and 31 of 118 (26 %) without adrenal medulla antibodies, and in 5 of 15 (33 % ) with and 31 of 118 (26 %) of patients without vagus nerve antibodies. The frequency of ICA, however, was significantly increased in patients with sympathetic ganglia antibodies compared with those without sympathetic ganglia antibodies (10 of 21 [48 %] vs 21 of 112 [19 %];p < 0.01). In conclusion, GAD-ab were neither associated with disturbed autonomic nerve function nor with antibodies against autonomic nerve structures. [Diabetologia (1994) 37: 293-299]

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Section: Subjects Materials and Methodsmentioning

confidence: 99%

Glutamic acid decarboxylase antibodies, autonomic nerve antibodies and autonomic neuropathy in diabetic patients

Sundkvist¹,

Velloso²,

K�mpe³

et al. 1994

Diabetologia

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“…(b) Respiratory influence on heart rate: The electrocardiogram (ECG) was recorded continuously during maximal deep breathing procedures. Variation in heart rate between 'Accepted 9 December 1980 inspiration and expiration of less than 10% was considered abnormal (Sundkvist et al 1979). …”

Section: Methodsmentioning

confidence: 99%

Sleep apnoea in diabetic patients with autonomic neuropathy

REES¹,

PRIOR²,

COCHRANE³

et al. 1980

British Journal of Diseases of the Chest

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“…The longest interval during expiration and the shortest R-R interval during inspiration were expressed as E: I ratio. [10] …”

Section: Assessment Of Expiratory: Inspiratory Ratio (E: I Ratio) In mentioning

confidence: 99%

Correlates of SDNN heart rate variability in healthy subjects and subjects with type 2 diabetes mellitus

Nk¹,

Adhikari²,

Poornima³

et al. 2015

Int J of Biomed & Adv Res

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Introduction: Standard deviation of R-R intervals (SDNN) predicts mortality in variety of clinical conditions. But little is known about correlates of SDNN. Objective: To investigate correlates of SDNN in healthy subjects and with type 2 diabetes. Materials and Methods: 115 male subjects with type 2 diabetes and 87 controls were studied. In them heart rate (HR), blood pressure (BP), body mass index (BMI), Q -Tc and SDNN were measured. Pearson correlation coefficient and unpaired t test were used for data analysis. P < 0.05 was considered significant. Results: In controls, SDNN was negatively correlating with age and HR (p < 0.05, <0.001 respectively). In subjects with type 2 diabetes, SDNN was negatively correlating with HR, diastolic blood pressure, Q-Tc and duration of diabetes (p < 0.0001, < 0.01, = 0.014, < 0.05 respectively); and was positively correlating with BMI (p < 0.05). Conclusion: Higher HR, DBP, prolonged Q-T interval and duration of diabetes are associated with reduced SDNN in subjects with type 2 diabetes. In them BMI could be a confounding factor while assessing cardiac autonomic dysfunction employing SDNN. In healthy subjects high HR and age are associated with reduced SDNN.

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Respiratory influence on heart rate in diabetes mellitus.

Cited by 241 publications

References 10 publications

Glutamic acid decarboxylase antibodies, autonomic nerve antibodies and autonomic neuropathy in diabetic patients

Glutamic acid decarboxylase antibodies, autonomic nerve antibodies and autonomic neuropathy in diabetic patients

Sleep apnoea in diabetic patients with autonomic neuropathy

Correlates of SDNN heart rate variability in healthy subjects and subjects with type 2 diabetes mellitus

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