Respiratory infections of the human bocavirus

Schildgen, Oliver; Schildgen, Verena

doi:10.1016/b978-0-12-804543-5.00005-1

Cited by 1 publication

(1 citation statement)

References 163 publications

(152 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although HBoV1-4 have been identified globally, predominantly in nasopharyngeal, fecal, cerebrospinal fluid, and blood specimens [ 2 – 8 ], the significance of HBoVs in infectious disease remains unclear [ 16 ]. Schildgen et al discussed that viral infections in general and those caused by HBoVs in particular are more complicated than previously believed, and suggested that the interpretation of molecular findings requires more sophisticated algorithms and a deeper knowledge of the molecular biology of contributing pathogens [ 17 ]. To explore the prevalence and phylogenetic characteristics of HBoV1-4 in pediatric patients with infectious disease belonging to different tissues, a retrospective, large-scale study (over an 8-year period) was undertaken to provide an explanation of HBoV molecular biology based on clinical information.…”

Section: Introductionmentioning

confidence: 99%

Prevalence and Phylogenetic Analysis of Human Bocaviruses 1-4 in Pediatric Patients with Various Infectious Diseases

et al. 2016

View full text Add to dashboard Cite

ObjectivesViral infections caused by human bocaviruses 1–4 (HBoV1-4) are more complicated than previously believed. A retrospective, large-scale study was undertaken to explore the prevalence of HBoV1-4 in pediatric patients with various infectious diseases and delineate their phylogenetic characteristics.MethodsClinical samples from four specimen types, including 4,941 respiratory, 2,239 cerebrospinal fluid (CSF), 2,619 serum, and 1,121 fecal specimens, collected from pediatric patients with various infectious diseases were screened for HBoV1-4. A 690-nt fragment in each specimen was then amplified and sequenced for phylogenetic analysis. Clinical characteristics of HBoV-positive patients with different specimen types available were evaluated.ResultsApproximately 1.2% of patients were confirmed as HBoV-positive, with the highest positive rate in patients with gastrointestinal infection (2.2%), followed by respiratory (1.65%), central nervous system (0.8%), and hematological infections (0.2%). A single genetic lineage of HBoV1 circulated among children over the 8-year period, while a new cluster of HBoV2, via intra-genotype recombination between HBoV2A and HBoV2B, was prevalent. Some patients had HBoV1-positive respiratory and serum specimens or fecal specimens. Several cases became HBoV1-positive following the appearance of respiratory infection, while several cases were positive for HBoV2 only in CSF and serum specimens, rather than respiratory specimens.ConclusionsA single genetic lineage of HBoV1 is speculated as a viral pathogen of respiratory infection and causes both comorbid infection and acute gastroenteritis. Additionally, a new cluster of HBoV2 is prevalent in China, which may infect the host through sites other than the respiratory tract.

show abstract

Section: Introductionmentioning

confidence: 99%