Respiratory impairment in persons with multiple sclerosis: A cross-sectional study

Abstract

Introduction:The spectrum of multiple sclerosis (MS) among all its clinical types includes a vast number of alterations. Of these, respiratory impairment carries big implications since this is an important cause of mortality and morbidity. Methods: Here, we present an observational study of respiratory assessment through spirometry in individuals with MS. Subjects who underwent autologous hematopoietic stem cell transplant from an interventional study were considered to participate. Results: An abnormal pattern of respiratory impairment was found in 147 participants; of this, 89.6% and 10.4% manifested a restrictive and obstructive pattern, respectively. The restrictive pattern was observed in 58 patients with secondary-progressive MS (SPMS) followed by 36 in patients with relapsing-remitting MS (RRMS) and, finally, 37 in patients with primary-progressive MS (PPMS). The full population had a mean forced expiratory volume of the 1 st s (FEV1) of 92%, while the RRMS, PPMS, and SPMS groups had 93%, 89%, 91%, respectively. The median FEV1/forced vital capacity (FVC) ratio was 82.8% in the full cohort, 83.3% in the RRMS group, 83% in the PPMS group, and 82% in the SPMS group. Negative correlations were found between predicted FVC and FEV1 with expanded disability status scale and FEV1/FVC. Conclusion: This study showed a considerable number of restrictive patterns among all the participants, being the SPMS the type of MS with higher respiratory involvement and with functional disability.

The 1,000th Transplant for Multiple Sclerosis and Other Autoimmune Disorders at the HSCT-México Program: A Myriad of Experiences and Knowledge

“…This contribution found that 31% of patients recruited for HSCT, with no important comorbidities and factors related to pulmonary dysfunction had an abnormal spirogram, most frequently with a restrictive pattern. Of note, there was a significant association of predicted values of forced vital capacity and forced expiratory volume with EDSS and disease duration ( 18 ).…”