Respiratory health outcomes 1 year after admission with severe lower respiratory tract infection

Trenholme, Adrian; Byrnes, Catherine A; McBride, Charissa; Lennon, Dianna; Chan-Mow, F.; Vogel, Alison; Stewart, Joanna; Percival, Teuila

doi:10.1002/ppul.22661

Cited by 27 publications

(49 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…21 In New Zealand, hospitalised ALRI rates in children aged <2 years are 103/1,000 nationally but reach 177/1,000 in South Auckland Māori and Pacifica children. 22 These higher rates in indigenous populations in affluent countries compared to developing countries is likely related to the invariably better data collection in affluent countries.…”

Section: Epidemiology and Contextmentioning

confidence: 99%

“…22,35 Obtaining accurate prevalence figures on bacteria pneumonia is problematic as differentiating bacterial from viral or mixed-cause pneumonia is difficult. Even the use of WHO-defined radiological pneumonia (end-point consolidation (EPC)) is fraught with problems especially in the clinical context.…”

Section: Pneumoniamentioning

confidence: 99%

“…39 In a New Zealand study of predominantly (94%) Māori and Pacifica children, 74% of the 81 children followed at 10-14 months after hospitalization for an ALRI, had features of ongoing respiratory morbidity (wet cough, auscultatory chest crackles, CXR abnormalities). 22 Several vaccines have reduced the worldwide incidence of pneumonia. However, the benefits from population-based vaccination programs are not universal.…”

Section: Pneumoniamentioning

confidence: 99%

See 2 more Smart Citations

Lung disease in indigenous children

Chang

Brown

Toombs

et al. 2014

Paediatric Respiratory Reviews

View full text Add to dashboard Cite

A c c e p t e d M a n u s c r i p t 2 EDUCATIONAL AIMSThe reader will be able to:• Discuss the common respiratory problems encountered by indigenous children.• Appreciate the similarities and differences in the aetiology, associations and management of these common respiratory problems.• Understand the many facets that impact on the clinical outcomes of common respiratory conditions affecting indigenous children.• Discuss potential intervention targets that can reduce the morbidity and mortality of respiratory diseases in indigenous children. Page 3 of 27A c c e p t e d M a n u s c r i p t 3 SUMMARY Children in indigenous populations have substantially higher respiratory morbidity than nonindigenous children. Indigenous children have more frequent respiratory infections that are, more severe and, associated with long-term sequelae. Post-infectious sequelae such as chronic suppurative lung disease and bronchiectasis are especially prevalent among indigenous groups and have lifelong impact on lung function. Also, although estimates of asthma prevalence among indigenous children are similar to non-indigenous groups the morbidity of asthma is higher in indigenous children. To reduce the morbidity of respiratory illness, best-practice medicine is essential in addition to improving socio-economic factors, (eg household crowding), tobacco smoke exposure, and access to health care and illness prevention programs that likely contribute to these issues. Although each indigenous group may have unique health beliefs and interfaces with modern health care, a culturally sensitive and community-based comprehensive care system of preventive and long term care can improve outcomes for all these conditions. This article focuses on common respiratory conditions encountered by indigenous children living in affluent countries where data is available.

show abstract

Section: Epidemiology and Contextmentioning

confidence: 99%

Section: Pneumoniamentioning

confidence: 99%

Section: Pneumoniamentioning

confidence: 99%

See 1 more Smart Citation

Lung disease in indigenous children

Chang

Brown

Toombs

et al. 2014

Paediatric Respiratory Reviews

View full text Add to dashboard Cite

show abstract

“…Recently an excellent follow-up study by Trenholme et al found that 74% of children post-hospitalisation for a severe LRTI either had a chronic moist cough, abnormal auscultatory chest sounds or abnormal chest radiograph 1 year later [8].…”

Section: Introductionmentioning

confidence: 99%

Clinical Risk Factors for Life-Threatening Lower Respiratory Tract Infections in Children: A Retrospective Study in an Urban City in Malaysia

et al. 2014

View full text Add to dashboard Cite

AimLower respiratory tract infections (LRTIs) are an important cause of morbidity and mortality, especially in low income countries. The aim of this study was to determine risk factors of life-threatening LRTIs in hospitalised children in Malaysia.MethodsThis retrospective study included children aged less than 18 years admitted for LRTIs over 13 months in a tertiary referral centre in Kuala Lumpur, Malaysia. Neonates, children with asthma and those with either no or a normal chest radiograph were excluded. Life-threatening infection was defined as that needing non-invasive ventilation or admission to the paediatric intensive care unit. Routine blood investigations and nasopharyngeal secretion results (bacterial and viral) were obtained. Chest radiographs were reviewed by a designated radiologist. Environmental data (rainfall, particulate matter ≤10 µm [PM10] and air pollution index [API]) was obtained from the respective government departments.ResultsThree hundred and ninety-one episodes of LRTIs were included. Viruses were implicated in 48.5% of LRTIs, with respiratory syncytial virus (RSV) being detected in 44% of viral LRTIs. Forty-six (11.8%) children had life-threatening disease and the overall mortality rate was 1.3% (5 children). RSV was detected in 26% of children with life-threatening LRTIs. In multivariate logistic regression, chronic lung disease, presenting history of apnoea and signs of hypoxia, was associated with life threatening LRTIs. Increased LRTI admissions were associated with low rainfall but not PM10 nor API. Of those on follow-up, 39% had persistent respiratory symptoms.ConclusionOne in nine children admitted with LRTI had a life-threatening LRTI. The aetiology was viral in almost half of admitted children. RSV was detected in a quarter of children with life-threatening LRTIs. Children who present with LRTIs and either have chronic lung disease, presenting history of apnoea or signs of hypoxia, should be observed carefully as the risk of deterioration to life-threatening illness is high.

show abstract

“…diagnosis or treatment) beyond the stated time points. A later study conducted in New Zealand however found that 74% of children <2 years of age had a history of chronic moist cough, moist cough or crackles and/or an abnormal chest x-ray 10–14 months after admission with severe lower respiratory tract infection [16]. Furthermore, there are no data detailing the types of ARIs that children present with in which a pre-existing chronic cough may be overlooked.…”

Section: Introductionmentioning

confidence: 99%

The development of chronic cough in children following presentation to a tertiary paediatric emergency department with acute respiratory illness: study protocol for a prospective cohort study

et al. 2013

View full text Add to dashboard Cite

BackgroundAcute respiratory illness, a leading cause of cough in children, accounts for a substantial proportion of childhood morbidity and mortality worldwide. In some children acute cough progresses to chronic cough (>4 weeks duration), impacting on morbidity and decreasing quality of life. Despite the importance of chronic cough as a cause of substantial childhood morbidity and associated economic, family and social costs, data on the prevalence, predictors, aetiology and natural history of the symptom are scarce. This study aims to comprehensively describe the epidemiology, aetiology and outcomes of cough during and after acute respiratory illness in children presenting to a tertiary paediatric emergency department.Methods/designA prospective cohort study of children aged <15 years attending the Royal Children’s Hospital Emergency Department, Brisbane, for a respiratory illness that includes parent reported cough (wet or dry) as a symptom. The primary objective is to determine the prevalence and predictors of chronic cough (≥4 weeks duration) post presentation with acute respiratory illness. Demographic, epidemiological, risk factor, microbiological and clinical data are completed at enrolment. Subjects complete daily cough dairies and weekly follow-up contacts for 28(±3) days to ascertain cough persistence. Children who continue to cough for 28 days post enrolment are referred to a paediatric respiratory physician for review. Primary analysis will be the proportion of children with persistent cough at day 28(±3). Multivariate analyses will be performed to evaluate variables independently associated with chronic cough at day 28(±3).DiscussionOur protocol will be the first to comprehensively describe the natural history, epidemiology, aetiology and outcomes of cough during and after acute respiratory illness in children. The results will contribute to studies leading to the development of evidence-based clinical guidelines to improve the early detection and management of chronic cough in children during and after acute respiratory illness.

show abstract

Respiratory health outcomes 1 year after admission with severe lower respiratory tract infection

Cited by 27 publications

References 40 publications

Lung disease in indigenous children

Lung disease in indigenous children

Clinical Risk Factors for Life-Threatening Lower Respiratory Tract Infections in Children: A Retrospective Study in an Urban City in Malaysia

The development of chronic cough in children following presentation to a tertiary paediatric emergency department with acute respiratory illness: study protocol for a prospective cohort study

Contact Info

Product

Resources

About