Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life?

Svanes, Øistein; Skorge, Trude Duelien; Johannessen, Ane; Bertelsen, Randi J.; Bråtveit, Magne; Forsberg, Bertil; Gíslason, T; Holm, Mathias; Janson, Christer; Jõgi, Rain; Macsali, Ferenc; Norbäck, Dan; Omenaas, Ernst; Real, Francisco Gómez; Schlünssen, Vivi; Sigsgaard, Torben; Wieslander, Gunilla; Zock, Jan‐Paul; Aasen, Tor; Dratva, Julia; Svanes, Cecilie

doi:10.1371/journal.pone.0131959

Cited by 46 publications

(38 citation statements)

References 32 publications

(33 reference statements)

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“…Long-term exposure to the occupational agent (eg, in persons who start work at a very young age and/or cannot change their workplace when the symptoms start) could play a role. For instance, a crosssectional study performed in 13 499 cleaners in Northern Europe investigated whether early life factors influenced susceptibility to the unhealthy effects of occupational cleaning [93]. Associations with respiratory symptoms, asthma, and self-reported COPD were analyzed with multiple logistic regression adjusted for sex, age, smoking, educational level, parents' educational level, body mass index, and participating center.…”

Section: Occupational Agentsmentioning

confidence: 99%

Early Life Origins of Asthma: A Review of Potential Effectors

Bobolea¹,

Arismendi²,

Valero³

et al. 2019

J Investig Allergol Clin Immunol

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There is growing evidence that events occurring early in life, both before and after birth, are significantly associated with the risk of asthma, chronic obstructive pulmonary disease, and diminished lung function later in life. In fact, from conception to death, a series of continuous, dynamic gene-environment interactions determine 2 fundamental biological processes, namely, lung development and lung aging. Over 130 birth cohorts have been initiated in the last 30 years. Data from these cohorts have improved our understanding of the inception, progression, and persistency of asthma. In this review, we summarize the main data for the early life events proven to determine later development and persistence of asthma, such as maternal atopy and smoking, preterm birth/bronchopulmonary dysplasia, infections, nutrition, obesity, smoking, and other environmental exposures in childhood and adolescence. While some of these factors are obviously impossible to prevent or eliminate, others have been proven to have a protective role, and current research is aimed optimizing them. Available prophylactic measures are also reviewed. In the case of environmental pollution, large scale political interventions successfully managed to decrease contamination levels, leading to improved lung function and lower asthma prevalence in the respective geographical areas. Future research should focus on better understanding these complex interactions in order to develop and enhance effective preventive therapeutic measures. ResumenExiste evidencia de que eventos que ocurren en fases tempranas de la vida, tanto antes como después del nacimiento, se asocian significativamente con el aumento del riesgo futuro de asma, enfermedad pulmonar obstructiva crónica y deterioro de la función pulmonar. En efecto, desde el momento de la concepción hasta la muerte, una serie de interacciones dinámicas y continuas genético-ambientales determinan dos procesos biológicos fundamentales, el desarrollo pulmonar y el envejecimiento pulmonar. En los últimos 30 años se han comenzado más de 130 cohortes de nacimiento. Los datos de estas cohortes han mejorado nuestra comprensión del inicio, la progresión y la persistencia del asma. En esta revisión, resumimos los datos principales de los eventos de la vida temprana probados que determinan el desarrollo y la persistencia posteriores del asma, como atopia materna y tabaquismo, parto prematuro/displasia broncopulmonar, infecciones, nutrición, obesidad, tabaquismo y otras exposiciones ambientales en la infancia y la adolescencia. Si bien algunos de estos factores son obviamente imposibles de prevenir o eliminar, se ha demostrado que otros tienen un papel protector, y la investigación actual apunta a optimizarlos. También se revisan las medidas profilácticas disponibles. En el caso de la contaminación ambiental, las intervenciones políticas a gran escala lograron disminuir los niveles de contaminación, lo que mejoró la función pulmonar y disminuyó la prevalencia de asma en las respectivas áreas geográficas. Las investiga...

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Section: Occupational Agentsmentioning

confidence: 99%

Early Life Origins of Asthma: A Review of Potential Effectors

Bobolea¹,

Arismendi²,

Valero³

et al. 2019

J Investig Allergol Clin Immunol

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“…Early life factors, in particular parental smoking, have been hypothesized to play a role for modifying susceptibility. [ 26 – 28 ]. No previous study on early life factors has yet followed participants into old age or had the power to investigate individual early life factors in sufficient detail.…”

Section: Introductionmentioning

confidence: 99%

Early Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years

et al. 2016

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ObjectivesEarly life environment is essential for lung growth and maximally attained lung function. Whether early life exposures impact on lung function decline in adulthood, an indicator of lung ageing, has scarcely been studied.MethodsSpirometry data from two time points (follow-up time 9–11 years) and information on early life exposures, health and life-style were available from 12862 persons aged 28–73 years participating in the European population-based cohorts SAPALDIA (n = 5705) and ECRHS (n = 7157). The associations of early life exposures with lung function (FEV1) decline were analysed using mixed-effects linear regression.ResultsEarly life exposures were significantly associated with FEV1 decline, with estimates almost as large as personal smoking. FEV1 declined more rapidly among subjects born during the winter season (adjusted difference in FEV1/year of follow-up [95%CI] -2.04ml [-3.29;-0.80]), of older mothers, (-1.82 ml [-3.14;-0.49]) of smoking mothers (-1.82ml [-3.30;-0.34] or with younger siblings (-2.61ml [-3.85;-1.38]). Less rapid FEV1-decline was found in subjects who had attended daycare (3.98ml [2.78;5.18]), and indicated in subjects with pets in childhood (0.97ml [-0.16;2.09]). High maternal age and maternal smoking appeared to potentiate effects of personal smoking. The effects were independent of asthma at any age.ConclusionEarly life factors predicted lung function decline decades later, suggesting that some mechanisms related lung ageing may be established early in life. Early life programming of susceptibility to adult insults could be a possible pathway that should be explored further.

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“…This result was in agreement with the study conducted in Iran [11], which depicted higher prevalence of breathlessness of exposed groups than controls with a significant p-value. Another study in Northern Europe [12] also found that respiratory symptoms and disease were more common among cleaners.…”

Section: Discussionmentioning

confidence: 87%

Assessment of Respiratory Symptoms Among cleaners in Governmental Hospitals in Addis Ababa, Ethiopia; Comparative Cross-sectional study

Getahun

Haile

Demeke

et al. 2019

Preprint

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Objective Respiratory disorders are the most common occupational diseases. Occupational exposures to dust, fumes, chemicals and gases are associated with increased prevalence of respiratory symptoms. Although cleaning represents a significant part of the working population worldwide, it is a relatively understudied occupation and respiratory health of professional cleaners in hospitals have not been significantly addressed in Ethiopia. The aim of this study was to assess the respiratory symptoms of cleaners working in hospital setting. A comparative cross sectional study design was employed on 140 study participants. The study was composed of 70 cleaners and 70 control subjects. Respiratory symptoms were assessed using standardized questionnaire. The data was coded, entered, cleaned and analyzed using SPSS version 20. Results Prevalence of dry cough, productive cough, wheezing, breathlessness and chest pain for cleaners was higher than the control group. Cleaners had odds of wheezing 2.05 times (OR 2.05, 95% CI: 0.77-5.50) than the controls. The odds of dry cough among cleaners was 4.7 times than among non-cleaners which was the most prevalent respiratory symptom. Based on the study the risk of developing respiratory symptoms were higher among cleaners than controls (p<0.05 to dry cough and breathlessness).

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Respiratory Health in Cleaners in Northern Europe: Is Susceptibility Established in Early Life?

Cited by 46 publications

References 32 publications

Early Life Origins of Asthma: A Review of Potential Effectors

Early Life Origins of Asthma: A Review of Potential Effectors

Early Life Origins of Lung Ageing: Early Life Exposures and Lung Function Decline in Adulthood in Two European Cohorts Aged 28-73 Years

Assessment of Respiratory Symptoms Among cleaners in Governmental Hospitals in Addis Ababa, Ethiopia; Comparative Cross-sectional study

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