Respiratory Health Effects of Ambient Air Pollution

Sava, Francesco; Carlsten, Chris

doi:10.1016/j.ccm.2012.07.003

Cited by 35 publications

(23 citation statements)

References 95 publications

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“…Exploration of genetic predispositions and epigenetic changes associated with ambient air pollution shows promising results [99]. Polymorphisms in genes coding for glutathione-S-transferases (GSTs), which are enzymes responsible for the metabolism of reactive oxygen species, are correlated with the risk of lung diseases such as asthma when individuals are exposed to ambient air pollution [100, 101].…”

Section: Macrophages and The Systemic Response Induced By Pmmentioning

confidence: 99%

“…Kerkhof et al showed that single-nucleotide polymorphisms in TLR2 and TLR4 genes significantly modified the effect of PM 2.5 on the incidence of asthma [102]. Ambient air pollution can induce epigenetic changes such as DNA methylation [103–107] and there is further promise for genome-wide association studies (GWAS) [99]. Little is known about the effect of gene-environment interactions on AM and more research in this field is required.…”

Section: Macrophages and The Systemic Response Induced By Pmmentioning

confidence: 99%

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Contribution of Lung Macrophages to the Inflammatory Responses Induced by Exposure to Air Pollutants

Hiraiwa

Eeden

2013

Mediators of Inflammation

210

135

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Large population cohort studies have indicated an association between exposure to particulate matter and cardiopulmonary morbidity and mortality. The inhalation of toxic environmental particles and gases impacts the innate and adaptive defense systems of the lung. Lung macrophages play a critically important role in the recognition and processing of any inhaled foreign material such as pathogens or particulate matter. Alveolar macrophages and lung epithelial cells are the predominant cells that process and remove inhaled particulate matter from the lung. Cooperatively, they produce proinflammatory mediators when exposed to atmospheric particles. These mediators produce integrated local (lung, controlled predominantly by epithelial cells) and systemic (bone marrow and vascular system, controlled predominantly by macrophages) inflammatory responses. The systemic response results in an increase in the release of leukocytes from the bone marrow and an increased production of acute phase proteins from the liver, with both factors impacting blood vessels and leading to destabilization of existing atherosclerotic plaques. This review focuses on lung macrophages and their role in orchestrating the inflammatory responses induced by exposure to air pollutants.

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Section: Macrophages and The Systemic Response Induced By Pmmentioning

confidence: 99%

Section: Macrophages and The Systemic Response Induced By Pmmentioning

confidence: 99%

Contribution of Lung Macrophages to the Inflammatory Responses Induced by Exposure to Air Pollutants

Hiraiwa

Eeden

2013

Mediators of Inflammation

210

135

View full text Add to dashboard Cite

show abstract

“…Such factors include exposure to identified physical and chemical agents and their mixtures and occupational and environmental activities. The latter may entail exposures occurred in or in proximity of some industrial facilities, air pollution due to road traffic and home heating [1][2][3][4][5][6]. Sufficient or convincing evidence about causes of bladder cancer is associated with cigarette smoking, radiation, exposure to aromatic amines, arsenic and inorganic arsenic compounds, Schistosoma haematobium, and work in occupations such as aluminum production, painting, and rubber production [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Residence in proximity of a coal-oil-fired thermal power plant and risk of lung and bladder cancer in north-eastern Italy. A population-based study, 1995-2009

Collarile¹,

Bidoli²,

Barbone³

et al. 2017

Preprint

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This study investigated the risk of lung and bladder cancers in people residing in proximity of a coal-oil-fired thermal power plant in an area of north-eastern Italy, covered by a population-based cancer registry. Incidence rate ratios (IRR) by sex, age, and histology were computed according to tertiles of residential exposure to benzene, nitrogen dioxide (NO 2 ), particular matter, and sulfur dioxide (SO 2 ) among 1076 incident cases of lung and 650 cases of bladder cancers. In men of all ages and in women under 75 years of age, no significant associations were observed. Conversely, in women aged ≥75 years significantly increased risks of lung and bladder cancers were related to high exposure to benzene (IRR for highest vs. lowest tertile: 2.00 for lung cancer and 1.94 for bladder cancer) and NO 2 (IRR: 1.72 for lung cancer; and 1.94 for bladder cancer). In these women, a 1.71-fold higher risk of lung cancer was also related to a high exposure to SO 2 . Acknowledging the limitations of our study, in particular that we did not have information regarding cigarette smoking habits, the findings of this study indicate that air pollution exposure may have had a role with regard to the risk of lung and bladder cancers limited to women aged ≥75 years. Such increased risk warrants further analytical investigations.

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“…Such factors include exposure to identified physical and chemical agents and their mixtures and occupational and environmental activities. The latter may entail exposures occurred in or in proximity of some industrial facilities [1,2], air pollution due to road traffic, heating of buildings and industrial emissions [3,4,5,6]. Sufficient or convincing evidence about causes of bladder cancer is associated with cigarette smoking, radiation, exposure to aromatic amines, arsenic and inorganic arsenic compounds, Schistosoma haematobium, and work in occupations such as aluminum production, painting, and rubber production [7,8,9].…”

Section: Introductionmentioning

confidence: 99%

Residence in Proximity of a Coal-Oil-Fired Thermal Power Plant and Risk of Lung and Bladder Cancer in North-Eastern Italy. A Population-Based Study, 1995–2009

Collarile¹,

Bidoli²,

Barbone³

et al. 2017

Preprint

View full text Add to dashboard Cite

Abstract:We assessed lung and bladder cancer risk in people living near a coal-oil-fired thermal power plant in an area of north-eastern Italy covered by a population-based cancer registry. Incidence rate ratios (IRR) by sex, age, and histology were computed according to tertiles of residential exposure to benzene, nitrogen dioxide (NO2), particular matter (PM10), and sulfur dioxide (SO2) among 1076 incident cases of lung and 650 cases of bladder cancers. In men of all ages and in women under 75 years of age, no significant associations were observed. Conversely, in women aged ≥ 75 years significantly increased risks of lung and bladder cancer were related to high exposure to benzene (IRR for highest vs. lowest tertile: 2.00 for lung cancer and 1.94 for bladder cancer) and NO2 (IRR: 1.72 for lung cancer; and 1.94 for bladder cancer). In these women, a 1.71-fold higher risk of lung cancer was also related to high exposure to SO2. The findings of this descriptive study indicate that air pollution may have a role with regard to the risk of lung and bladder cancers, limited to women aged ≥ 75 years. Such increased risk warrants further analytical investigations.

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Respiratory Health Effects of Ambient Air Pollution

Cited by 35 publications

References 95 publications

Contribution of Lung Macrophages to the Inflammatory Responses Induced by Exposure to Air Pollutants

Contribution of Lung Macrophages to the Inflammatory Responses Induced by Exposure to Air Pollutants

Residence in proximity of a coal-oil-fired thermal power plant and risk of lung and bladder cancer in north-eastern Italy. A population-based study, 1995-2009

Residence in Proximity of a Coal-Oil-Fired Thermal Power Plant and Risk of Lung and Bladder Cancer in North-Eastern Italy. A Population-Based Study, 1995–2009

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