Respiratory gases, air pollution and epilepsy

Fernandes, Maria José da Silva; Carletti, Corrado; Araújo, Luis Fernando Sierra de; Santos, R. F.; Reis, Jacques

doi:10.1016/j.neurol.2019.07.013

Cited by 16 publications

(17 citation statements)

References 82 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…21 Chronic bronchitis was a comorbidity associated with history of epilepsy among Italian nursing home residents. 22 Although cellular mechanisms activated by air pollution may represent risk factors for epilepsy and drug resistance 23 and obstructive sleep apnea has been associated with drug resistance in epilepsy, 24 to our knowledge there are no published reports showing that people with epilepsy and pulmonary diseases are at higher than expected risk of developing poor response to the available ASM. This purported association needs further investigation.…”

Section: Discussionmentioning

confidence: 99%

Comorbidities in patients with epilepsy: Frequency, mechanisms and effects on long‐term outcome

et al. 2021

View full text Add to dashboard Cite

To assess frequency, types, and mechanisms of comorbidities in people with epilepsy and verify their association with disease features and outcome. Methods: This cohort study was performed in 13 Italian epilepsy centers with nationwide distribution and accurate records. Eligible patients were children and adults diagnosed before December 31, 2005, and followed for a minimum of 10 years. Two pairs of raters independently reviewed patients' records and classified each comorbidity. In case of disagreement, a third reviewer made the final decision. Comorbidities were classified according to type (organ/system) and underlying mechanism (causal, shared risk factors, chance association). Comorbidity types and mechanisms were described in the entire sample and according to epilepsy prognostic patterns (sustained remission, relapsing-remitting course, no remission). Results: Of 1006 included patients, 266 (26.4%) had at least one comorbidity. The most common were developmental/perinatal (7.5% of cases), psychiatric (6.2%), cardiovascular (5.3%), and endocrine/metabolic (3.8%). Among 408 reported comorbidities, the underlying mechanisms were, in decreasing order, chance association (42.2%), shared risk factors (31.1%), and causal (26.7%). Psychiatric diseases were present in 13.3% of patients with no remission, 5.9% of patients with relapsingremitting course, and 4.8% of patients with sustained remission (p = .016). The corresponding numbers for endocrine/metabolic diseases were respectively, 9.6%, 3.4%, and 2.9% (p = .013); for respiratory diseases were 3.6%, .3%, and .3% (p = .001), and for urogenital diseases were 3.6%, .7%, and 1.6% (p = .048). The association of endocrine/metabolic, psychiatric, and respiratory comorbidities with epilepsy prognosis was confirmed by multivariable analysis adjusted for the main demographic and

show abstract

Section: Discussionmentioning

confidence: 99%

Comorbidities in patients with epilepsy: Frequency, mechanisms and effects on long‐term outcome

et al. 2021

View full text Add to dashboard Cite

show abstract

“…In recent years, systematic research into the health issues caused by air pollution has been directly focused on the effects of firework-related pollutants [ 11 , 12 ]. Findings from studies on mental disorders have also revealed that short-term air pollution exposure is associated with an increased risk of hospitalizations related to attention-deficit/hyperactivity disorder (ADHD) [ 54 ], depression [ 54 ], schizophrenia, and epileptic seizures and/or hospitalizations [ 55 , 56 , 57 , 58 , 59 ]. Further, early research suggests that short term exposure to high air pollution concentrations could play a role in COVID-19 outcomes and exacerbations [ 60 , 61 ].…”

Section: Discussionmentioning

confidence: 99%

Impact of 4th of July Fireworks on Spatiotemporal PM2.5 Concentrations in California Based on the PurpleAir Sensor Network: Implications for Policy and Environmental Justice

Mousavi

Yuan

Masri

et al. 2021

IJERPH

View full text Add to dashboard Cite

Fireworks are often used in celebration, causing short term, extremely high particulate matter air pollution. In recent years, the rapid development and expansion of low-cost air quality sensors by companies such as PurpleAir has enabled an understanding of air pollution at a much higher spatiotemporal resolution compared to traditional monitoring networks. In this study, real-time PM2.5 measurements from 751 PurpleAir sensors operating from June to July in 2019 and 2020 were used to examine the impact of 4th of July fireworks on hourly and daily PM2.5 concentrations at the census tract and county levels in California. American Community Survey (ACS) and CalEnviroScreen 3.0 data were used to identify correlations between PM2.5 measurements and socioeconomic status (SES). A two-step method was implemented to assure the quality of raw PM2.5 sensor data and sensor calibration against co-located reference instruments. The results showed that over 67% and 81% of counties experienced immediate impacts related to fireworks in 2019 and 2020, respectively. Relative to 2019, the peak PM2.5 concentrations on July 4th and 5th 2020 were, on average, over 50% higher in California, likely due to the COVID-19-related increase in the use of household-level fireworks. This increase was most pronounced in southern counties, which tend to have less strict firework-related regulations and a greater use of illegal fireworks. Los Angeles County experienced the highest July 4th daily PM2.5 levels both in 2019 (29.9 µg·m−3) and 2020 (42.6 µg·m−3). Spatial hot spot analyses generally showed these southern counties (e.g., Los Angeles County) to be regional air pollution hotspots, whereas the opposite pattern was seen in the north (e.g., San Francisco). The results also showed PM2.5 peaks that were over two-times higher among communities with lower SES, higher minority group populations, and higher asthma rates. Our findings highlight the important role that policy and enforcement can play in reducing firework-related air pollution and protecting public health, as exemplified by southern California, where policy was more relaxed and air pollution was higher (especially in 2020 when the 4th of July coincided with the COVID-19-lockdown period), and in disadvantaged communities where disparities were greatest.

show abstract

“…However, another study, performed in the city of Xi'an, showed that NO 2 and SO 2 were positively associated with epilepsy [418]. In support of such observations, a growing number of studies have shown that exposures to air pollutants can activate cellular mechanisms involved in epilepsy [478].…”

Section: Epilepsymentioning

confidence: 93%

Brain Disorders and Chemical Pollutants: A Gap Junction Link?

et al. 2020

View full text Add to dashboard Cite

The incidence of brain pathologies has increased during last decades. Better diagnosis (autism spectrum disorders) and longer life expectancy (Parkinson’s disease, Alzheimer’s disease) partly explain this increase, while emerging data suggest pollutant exposures as a possible but still underestimated cause of major brain disorders. Taking into account that the brain parenchyma is rich in gap junctions and that most pollutants inhibit their function; brain disorders might be the consequence of gap-junctional alterations due to long-term exposures to pollutants. In this article, this hypothesis is addressed through three complementary aspects: (1) the gap-junctional organization and connexin expression in brain parenchyma and their function; (2) the effect of major pollutants (pesticides, bisphenol A, phthalates, heavy metals, airborne particles, etc.) on gap-junctional and connexin functions; (3) a description of the major brain disorders categorized as neurodevelopmental (autism spectrum disorders, attention deficit hyperactivity disorders, epilepsy), neurobehavioral (migraines, major depressive disorders), neurodegenerative (Parkinson’s and Alzheimer’s diseases) and cancers (glioma), in which both connexin dysfunction and pollutant involvement have been described. Based on these different aspects, the possible involvement of pollutant-inhibited gap junctions in brain disorders is discussed for prenatal and postnatal exposures.

show abstract

Respiratory gases, air pollution and epilepsy

Cited by 16 publications

References 82 publications

Comorbidities in patients with epilepsy: Frequency, mechanisms and effects on long‐term outcome

Comorbidities in patients with epilepsy: Frequency, mechanisms and effects on long‐term outcome

Impact of 4th of July Fireworks on Spatiotemporal PM2.5 Concentrations in California Based on the PurpleAir Sensor Network: Implications for Policy and Environmental Justice

Brain Disorders and Chemical Pollutants: A Gap Junction Link?

Contact Info

Product

Resources

About