Respiratory Failure of Acute Organophosphate and Carbamate Poisoning

Tsao, Thomas Chang-Yao; Juang, Yeong-Chang; Lan, Ray-Shee; Shieh, Wen-Bin; Lee, Cheng-Huei

doi:10.1378/chest.98.3.631

Cited by 137 publications

(93 citation statements)

References 11 publications

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“…The severity of OP poisoning differs depending upon the compound and its quantity, the way the exposure has occurred and the time at which treatment is initiated. Pesticide poisonings have a low mortality rate (0.04% to 1%) as long as they are treated appropriately; and the major reason for death is respiratory insufficiency 45. OPs lead to undesired effects on the central nervous system, cardiovascular system, respiratory system, urogenital system, neuromuscular junction, and metabolic and endocrine systems.…”

mentioning

confidence: 99%

The prognostic value of the Glasgow coma scale, serum acetylcholinesterase and leukocyte levels in acute organophosphorus poisoning

Cander

Dur

Yıldız

et al. 2011

Annals of Saudi Medicine

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BACKGROUND AND OBJECTIVES:Organophosphate poisoning (OP) is a serious clinical condition that may sometimes be fatal. The aim of this study was to determine whether the Glasgow coma scale (GCS), and serum acetylcholinesterase and leukocyte levels have prognostic value in acute OP poisoning.DESIGN AND SETTING:Retrospective review of records of patients admitted to the intensive care unit of Selcuk University, Meram Medical Faculty, Emergency Department, Konya, Turkey, between January 2006 and January 2009.METHODS:We studied acutely OP-poisoned patients admitted within 24 hours after OP exposure.RESULTS:The mean age of the 25 patients was 37 years (range, 20-80 years). Three (12%) of the 25 patients (male-female ratio, 12:13) died. The mean GCS values of the patients who died were significantly lower compared to those of the group that survived (4 vs 11.7, respectively P<.05). While the mean serum acetylcholinesterase levels were lower in the patients who died, the difference in the mean serum acetylcholinesterase levels between the patients who died and the ones who survived was not statistically significant (3841 IU/L vs. 1768 IU/L, respectively).CONCLUSION:Although serum cholinesterase values can be used in the quick diagnosis, their efficiency at predicting outcome in patients with OP poisoning has not been established. It has also been determined that serum leukocyte values have no prognostic value in OP poisoning, but GCS values have been found to be effective in predicting the outcome.

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confidence: 99%

The prognostic value of the Glasgow coma scale, serum acetylcholinesterase and leukocyte levels in acute organophosphorus poisoning

Cander

Dur

Yıldız

et al. 2011

Annals of Saudi Medicine

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“…(10)(11)(12) In most of the studies. (10)(11)(12)(13)(14) incidence of poisoning was common among female, but in our study males were commonly affected. Basic steps involved in the treatment of poisoning are 1.…”

Section: Discussionmentioning

confidence: 61%

A Case Control Study of Intravenous Magnesium Sulphate in Treatment of Acute Organophosphate Poisoning

Philomena¹,

Sathi²,

Parthasarathy³

2016

jemds

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“…This was in concordance with 2 studies Namba et al 10 and Philip et al 11 . All 36.8 % patients who developed respiratory failure required mechanical ventilation [12][13][14] . The pathogenesis is multifactorial and related to aspiration of gastric contents, excessive secretion in the airways, intermediate syndrome, pulmonary infection, septicaemia and the development of adult respiratory distress syndrome 12 .…”

Section: Discussionmentioning

confidence: 99%

Profile of Organophosphorus Insecticides Poisoning in Kasturba Hospital, Manipal, South India

Raghavan¹,

Amar²,

Nayak³

et al. 2014

J Pharm Sci Innov.

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in a tertiary care hospital at Manipal in Southern India, and a profile of the victims of pesticide poisoning was prepared. The objective of the study was to recognise the magnitude and pattern of poisoning in relation to the manner of consumption in this region of Southern India. In the present study, the young productive age group between 20-40 years were mostly affected. Males were predominantly affected. The most common compound was chlorpyrifos. Vomiting was the most common symptom. The most common sign was dilated pupils as against the usually observed sign of miosis which was attributed to atropine received from referral hospital. Among the complications, respiratory failure followed by pneumonia was commonly observed with severe pneumonia being the most common cause of mortality.

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Respiratory Failure of Acute Organophosphate and Carbamate Poisoning

Cited by 137 publications

References 11 publications

The prognostic value of the Glasgow coma scale, serum acetylcholinesterase and leukocyte levels in acute organophosphorus poisoning

The prognostic value of the Glasgow coma scale, serum acetylcholinesterase and leukocyte levels in acute organophosphorus poisoning

A Case Control Study of Intravenous Magnesium Sulphate in Treatment of Acute Organophosphate Poisoning

Profile of Organophosphorus Insecticides Poisoning in Kasturba Hospital, Manipal, South India

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