Respiratory failure in patients infected with SARS-CoV-2

Vashisht, Rishik; Duggal, Abhijit

doi:10.3949/ccjm.87a.ccc025

Cited by 5 publications

(3 citation statements)

References 10 publications

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“…The diagnostic criteria for respiratory failure is (a) respiratory rate of 30 per minute or more; (b) blood oxygen saturation 93% or less; (c) partial pressure of arterial oxygen to the fraction of inspired oxygen ratio (Pa o 2 :F io 2 ) less than 300 mm Hg; and (d) infiltrates in greater than 50% lung fields. Respiratory failure is frequently severe enough to produce brain hypoxia 76,77 …”

Section: Hypoxiamentioning

confidence: 99%

Encephalopathy in patients with COVID‐19: A review

Garg

Paliwal²,

Gupta

2020

Journal of Medical Virology

180

195

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Encephalopathy and encephalitis are major and devastating severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) virus-associated central nervous system complications. Hypoxic/metabolic changes produced by intense inflammatory response against the virus triggers cytokine storm and subsequently acute respiratory distress syndrome and multiple organ failure. Hypoxic/metabolic changes result in encephalopathy. The presence of comorbidities predisposes to hypoxic/metabolic changes responsible for encephalopathy. Altered consciousness, ranging from mild confusion, delirium, to deep coma, is hallmark clinical features. Cortical and subcortical T2/FLAIR signal changes are common neuroimaging abnormalities. In a few isolated case reports of SARS-CoV-2 encephalitis, the virus has been demonstrated in cerebrospinal fluid. The presence of anosmia and ageusia can help in differentiation from other encephalopathies. We analyzed published reports on coronavirus disease 2019-associated encephalopathy. Encephalopathy is common in older patients, the majority are more than 50 years of age. The patients having encephalopathy/encephalitis are either severely or critically ill. Many patients were already on mechanical ventilation. Lung abnormalities are noted in almost all of the patients, presenting with encephalopathy. Encephalopathy is always preceded by commoner clinical features, like, fever, cough, dyspnoea, and headache. In majority, patients are already in the intensive care unit, when encephalopathy develops.

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Section: Hypoxiamentioning

confidence: 99%

Encephalopathy in patients with COVID‐19: A review

Garg

Paliwal²,

Gupta

2020

Journal of Medical Virology

180

195

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“…At the start of the pandemic, fear of aerosolization and contamination of healthcare personnel by SARS-COV-2 created some hesitation in the use of mechanical ventilation, causing deaths following late intubations. Hence the low intubation rate of 4.7% compared to 88% according to the WHO in 2020 [22].…”

Section: Discussionmentioning

confidence: 94%

Evolving profile of severe and critical COVID-19 according: Cases admitted to the University Hospital of Kinshasa (UHK) = the official name of the institution from March 24, 2020 to December 12, 2022

Sonzi,

Risassi,

Ndona

et al. 2023

Preprint

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Background: Severe and critical forms of COVID-19 require early conventional oxygen therapy. Objective: The aim of this study was to analyze the evolution of Severe and critical COVID-19 patients treated at the University Hospital of Kinshasa according to News score. Methods: This was a historical cohort study carried out at the COVID-19 Treatment Center (of the University Hospital of Kinshasa (UHK) from March 24, 2020 to December 12, 2022. The target population was all patients (1159) admitted to the intensive care unit of the COVID-19 Treatment Center of the UHK. All tests were two-tailed with 95% CI and considered significant when P-value was < 0.05. Results: Of a total of 1159 patients, severe and critical forms accounted for 84.2% (n=976), with the age category of patients over 60 years the most represented at 52.2% (n=605), with a mean age of 58.1±17.3 years. Severe and critical patients with at least one comorbidity 74.2% (n=724) were admitted to CTCO CUK and 84.6% (n=981) of these patients required respiratory support with conventional oxygen therapy. Factors predictive of lethality were the use of CPAP and mechanical ventilation with HRa (95% CI) of 0.001 and 0.002 respectively, age> 60 years and late referral to UHK. Conclusion: Ultimately, this study showed that severe COVID-19 patients require early and effective management.

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“…The position of the patient is also an important factor to evaluate in the actual case and stage. The proposed prone position [378] needs to be applied in the proper timecourse [379]; otherwise, it could cause damages [380].…”

Section: Challenges Of the Therapeutic Paradigm And Management Of Thementioning

confidence: 99%

A Bioelectromagnetic Proposal Approaching the Complex Challenges of COVID-19

Szász¹

2021

OJBIPHY

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Respiratory failure in patients infected with SARS-CoV-2

Cited by 5 publications

References 10 publications

Encephalopathy in patients with COVID‐19: A review

Encephalopathy in patients with COVID‐19: A review

Evolving profile of severe and critical COVID-19 according: Cases admitted to the University Hospital of Kinshasa (UHK) = the official name of the institution from March 24, 2020 to December 12, 2022

A Bioelectromagnetic Proposal Approaching the Complex Challenges of COVID-19

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