Respiratory failure due to muscle weakness in inflammatory myopathies: maintenance therapy with home mechanical ventilation

Selva-O’Callaghan, Albert; Sanchez‐Sitjes, L.; Muñoz, Xavier; Mijares‐Boeckh‐Behrens, T.; Soláns-Laqué, Roser; Bosch‐Gil, Josep Angel; Morell‐Brotad, F.; Vilardell-Tarrés, M.

doi:10.1093/rheumatology/39.8.914

Cited by 45 publications

(28 citation statements)

References 16 publications

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“…PM is a rare paraneoplastic syndrome of breast cancer. Moreover, respiratory muscle involvement in PM is uncommon, and fatal respiratory failure is especially extremely rare [19]. No similar cases have been described in literature, so we believe this is the first reported case of a patient developing respiratory failure requiring mechanical assistant ventilation as a complication of breast cancer related polymyositis.…”

Section: Discussionmentioning

confidence: 74%

“…Respiratory muscle weakness and hypercapnea should be treated by mechanical ventilation and corticosteroids. When treatment with corticosteroids fails, the patient should be treated with agents such as methotrexate, azathioprine, cyclophosphamide, intravenous immune globulin, cyclosporine, tacrolimus, alkylating agents, and tumor necrosis factor inhibitors [19,21].…”

Section: Discussionmentioning

confidence: 99%

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Invasive ductal breast cancer associated polymyositis causing respiratory failure

Qiu

Huang

et al. 2010

Breast Cancer Res Treat

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Polymyositis (PM) is a very rare paraneoplastic syndrome in association with breast cancer, here we present a breast cancer patient with a sudden onset of respiratory failure caused by PM. A 47-year-old woman, with a history of a lump in her right breast for 3 months, weakness and anorexia for about 1 month, suddenly presented with respiratory failure and elevated muscle enzymes. Muscle biopsy revealed myositis and breast biopsy was consistent with invasive ductal breast cancer. Decreases of muscle enzyme levels were observed after corticosteroid therapy and the lumpectomy, but the patient died from respiratory failure. A case of respiratory failure caused by breast cancer associated polymyositis was presented. This case server to remind that breast cancer patients with muscle weakness or muscle enzyme elevation may be involved with PM.

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Section: Discussionmentioning

confidence: 74%

Section: Discussionmentioning

confidence: 99%

Invasive ductal breast cancer associated polymyositis causing respiratory failure

Qiu

Huang

et al. 2010

Breast Cancer Res Treat

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“…Maintenance therapy with noninvasive positive pressure ventilation improves quality of life, and, in severe cases, tracheostomy with home mechanical ventilation can be lifesaving. 14 …”

Section: Ventilatory Failure Caused By Muscle Weaknessmentioning

confidence: 99%

Pulmonary Complications of Inflammatory Myopathy

Miller¹,

Glassberg²,

Ascherman³

2015

Rheumatic Disease Clinics of North America

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“…One case of antisynthetase syndrome had isolated respiratory muscle weakness [102] (although it should be emphasised that the more common cause of respiratory failure in these patients is interstitial lung disease). Other reports exist of patients having been admitted to the ICU for respiratory muscle weakness due to PM [103] or DM [104], (although it should be noted many of these presented acutely to hospital rather than with chronic ERF to ambulatory clinics); in the DM patients most of these were early in the course of their disease and the authors emphasise the high mortality for these patients [104]. There is also a case report of a patient with respiratory muscle weakness occurring 5 years after onset of limb symptoms in a patient with IBM [105].…”

Section: Inflammatory Myopathymentioning

confidence: 99%

Diagnosis of muscle diseases presenting with early respiratory failure

et al. 2014

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Here we describe a clinical approach and differential diagnosis for chronic muscle diseases which include early respiratory failure as a prominent feature in their presentation (i.e. respiratory failure whilst still ambulant). These patients typically present to neurology or respiratory medicine out-patient clinics and a distinct differential diagnosis of neuromuscular aetiologies should be considered. Amyotrophic lateral sclerosis and myasthenia gravis are the important non-muscle diseases to consider, but once these have been excluded there remains a challenging differential diagnosis of muscle conditions, which will be the focus of this review. The key points in the diagnosis of these disorders are being aware of relevant symptoms, which are initially caused by nocturnal hypoventilation or diaphragmatic weakness; and identifying other features which direct further investigation. Important muscle diseases to identify, because their diagnosis has disease-specific management implications, include adult-onset Pompe disease, inflammatory myopathy, and sporadic adult-onset nemaline myopathy. Cases which are due to metabolic myopathy or muscular dystrophy are important to diagnose because of their implications for genetic counselling. Myopathy from sarcoidosis and colchicine each has a single reported case with this presentation, but should be considered because they are treatable. Disorders which have recently had their genetic aetiologies identified include hereditary myopathy with early respiratory failure (due to TTN mutations), the FHL1-related syndromes, and myofibrillar myopathy due to BAG3 mutation. Recently described syndromes include oculopharyngodistal muscular dystrophy that awaits genetic characterisation.

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Respiratory failure due to muscle weakness in inflammatory myopathies: maintenance therapy with home mechanical ventilation

Cited by 45 publications

References 16 publications

Invasive ductal breast cancer associated polymyositis causing respiratory failure

Invasive ductal breast cancer associated polymyositis causing respiratory failure

Pulmonary Complications of Inflammatory Myopathy

Diagnosis of muscle diseases presenting with early respiratory failure

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