Respiratory Failure

Martin, Lawrence

doi:10.1016/s0025-7125(16)31267-6

Cited by 14 publications

(1 citation statement)

References 66 publications

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“…TST, SE, N1, N2, N3, and R did not differ significantly between the two groups (Figure 3, Table 2). CRF in patients is usually diagnosed based on clinical definitions, which are all based on the presence of hypoxemia and categorized depending on whether being accompanied by hypercapnia [19][20][21]. This means that all CRF patients have hypoxemia and that the study needs to be conducted with the influence of hypoxemia excluded by the means of oxygen administration.…”

Section: Discussionmentioning

confidence: 99%

A study on sleep architecture in patients with chronic respiratory failure under long-term oxygen therapy—Focused on the influence of ventilatory failure (high CO<sub>2</sub>) elements on the patient’s sleep architecture

Nishijima¹,

Hosokawa²,

Mito³

et al. 2013

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Sleep disturbance related symptoms are common in patients with long-term oxygen therapy (LTOT). Essentially, there were only few previous reports about the sleep architecture in patients with respiratory disease, such as chronic obstructive pulmonary disease (COPD). This study aims to clarify the objective sleep state and the elements that affect sleep architecture in Chronic Respiratory Failure (CRF) patients with focus on clinical cases of chronic hypercapnia. 13 subjects with chronic respiratory failure were enrolled in the study. All the subjects were preevaluated by pulmonary function test and Arterial blood gas analysis (ABG) including exercise testing. Polysomnography (PSG) test was performed in each subject with supplemental oxygen. The estimated base line PaCO 2 value that reflects overall PaCO 2 including sleep period was calculated using equation of from obtained ABG value just before PSG test. 6 subjects were classified as hypercapnic group (base line PaCO 2 ≥ 45 mmHg) and 7 subjects were non-hypercapnic group (base line PaCO 2 < 45 mmHg). Latency persistent sleep of PSG data was significant higher in patients with hypercapnic than non-hypercapnic (p < 0.01). Periodic Limb Movement was seen in 23.6% of the subjects, however there was no contribution for arousals. Other PSG data include mean SpO 2 were no significant difference. This study suggests that patients with estimated hypercapnia had more disturbed sleep architecture especially significant loss of sleep latency than non-hypercapnic patient with chronic respiratory failure under LTOT. Nocturnal PaCO 2 level or ventilatory function may contribute to sleep disturbance in patients with estimated hypercapnia during LTOT. ( )[ . ]

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Section: Discussionmentioning

confidence: 99%