Respiratory epithelial adenomatoid hamartoma associated with nasal polyposis

Delbrouck, Carine; Aguilar, Sergio Fernandez; Choufani, Georges; Hassid, Sergio

doi:10.1016/j.amjoto.2004.02.005

Cited by 55 publications

(69 citation statements)

References 7 publications

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“…Respiratory epithelial adenomatoid hamartomas of the nasal cavity are usually associated with nasal polyposis. This association supports the hypothesis that inflammation is one of the factors that induces the development of a hamartoma [4].…”

Section: Discussionsupporting

confidence: 75%

REAH : Unusual Case of Unilateral Nasal Blockage

Bahal

Gupta²,

Lakhtakia

2008

Medical Journal Armed Forces India

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Section: Discussionsupporting

confidence: 75%

REAH : Unusual Case of Unilateral Nasal Blockage

Bahal

Gupta²,

Lakhtakia

2008

Medical Journal Armed Forces India

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“…This hypothesis arises from the observed occurrence of REAH in the setting of rhinosinusitis, inflammatory polyposis, and sinus surgery. 1,3,4 Our case was associated with allergic inflammation and chronic sinusitis, supporting the idea that inflammation may be a contributing factor in the development of REAH.…”

Section: Discussionmentioning

confidence: 55%

“…1 Imaging studies frequently reveal an expansile soft-tissue mass connected to the nasal septum with opacification of adjacent sinuses. [4][5][6]8 Calcification may be visualized within the lesion, but bone erosion and intracranial invasion are uncommon. 6 MR imaging findings of REAH include a mass that is hypo-to isointense relative to brain on T1-weighted images with a variable pattern of enhancement.…”

Section: Discussionmentioning

confidence: 99%

“…Most cases have occurred in adult men, and associations with tobacco use, asthma, and nasal polyposis have been noted. 1,[3][4][5] Most patients have isolated disease of the nasal cavity, though sinus involvement with or without nasal disease has been reported. 1,[5][6][7] Within the nasal cavity, REAH preferentially involves the posterior nasal septum and usually occurs unilaterally.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Respiratory Epithelial Adenomatoid Hamartoma of the Bilateral Olfactory Recesses: A Neoplastic Mimic?: Fig 1.

Seol¹,

LiVolsi²,

O’Malley³

et al. 2009

AJNR Am J Neuroradiol

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SUMMARY: REAH is a rare benign lesion of the sinonasal tract. The nasal cavity, particularly the posterior nasal septum, is the most common site of involvement. It usually occurs unilaterally and can be cured with conservative surgical resection. We present an unusual case of adenomatoid hamartoma involving bilateral olfactory recesses and discuss the importance of distinguishing this from other neoplastic processes that may lead to overly aggressive treatment.ABBREVIATIONS: H&E ϭ hematoxylin-eosin; IP ϭ inverted papilloma; REAH ϭ respiratory epithelial adenomatoid hamartoma; SNAC ϭ sinonasal adenocarcinoma A hamartoma is a malformation of tissue that is indigenous to the involved anatomic site. It has no capacity for unimpeded proliferation and causes symptoms mainly related to mass effect on adjacent structures. Hamartomas can occur anywhere in the body, but involvement of the head and neck is exceedingly uncommon.A particular subset known as REAH was first characterized in 1995 and represents a rare lesion of the sinonasal tract.1 It is important to distinguish REAH from more aggressive neoplastic processes because REAH is a benign entity that can be cured with conservative surgical resection. Case ReportAn otherwise healthy 60-year-old woman presented with headaches of 2 weeks' duration. She also complained of nasal congestion, an altered sense of smell, and stuffiness in both ears. Her medical history was notable for environmental allergies and chronic sinusitis. Findings of physical examination and laboratory work-up were unremarkable.MR and CT imaging were performed, which revealed an enhancing soft-tissue mass in the anterior left nasal cavity involving the olfactory recess and a similar-appearing smaller mass in the right olfactory recess (Fig 1AϪC). There were no destructive bone changes or intracranial extension. The uninvolved paranasal sinuses were clear. Imaging findings were most consistent with a primary neoplasm of the sinonasal cavity.Endoscopic biopsy revealed a REAH, which was subsequently resected endoscopically. On examination, the masses involved the anterior frontal skull base and bilateral olfactory recesses, left greater than right, and extended to the root of the middle turbinate. The masses were completely excised by using an endoscopic approach.The masses measured 1.5 (left) and 0.8 cm (right) and were microscopically similar (Fig 1D, -E). They contained many enlarged glands lined by ciliated respiratory epithelium. The periglandular connective tissue was attenuated and fibrotic, consistent with basement membrane thickening. Intervening stroma resembled that of inflammatory sinonasal polyps (ie, loose connective tissue with edema), vascular congestion, and moderate numbers of chronic inflammatory cells. Stains for ␤ catenin and smooth muscle actin showed positivity in the stromal cells, identical to those of a typical sinonasal polyp. Stains for S-100, c-kit, and CD34 were negative in the stromal cells. Notably, lobulated seromucinous glands were absent. These characteristic histolog...

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“…Baş-boyunda oldukça nadirdirler. 3,4 Respiratuar epitelyal adenomatoid hamartom (REAH) ilk defa 1995 yılında Wenig ve Heffner tarafından tariflenmiştir.…”

Section: Introductionunclassified

Respiratory epithelial adenomatoid hamartoma on the anterior nasal septum

Bozkurt¹,

Koc²,

Altay³

et al. 2012

Dicle Med J

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Respiratory epithelial adenomatoid hamartoma (REAH) is a rare benign lesion of the sinonasal cavity. In this report, by physical examination in the anterior part of the nasal cavity, on the septum a mass lesion was detected and paranasal sinus computed tomography (PSCT) performed. On PSCT; bounded, homogenious, solid lesion was shown and no evidence of invasion of surrounding bone and cartilage structures. Histopathologic diagnosis of the lesion was evaluated as REAH. Though REAH is a very rare benign lesion of sinonasal cavity the treatment is only simple excision. Therefore keeping it in mind in differential diagnosis list, aggressive surgical procedures should be avoided. The clinical and radiological features are discussed in the light of the literature.

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Respiratory epithelial adenomatoid hamartoma associated with nasal polyposis

Cited by 55 publications

References 7 publications

REAH : Unusual Case of Unilateral Nasal Blockage

REAH : Unusual Case of Unilateral Nasal Blockage

Respiratory Epithelial Adenomatoid Hamartoma of the Bilateral Olfactory Recesses: A Neoplastic Mimic?: Fig 1.

Respiratory epithelial adenomatoid hamartoma on the anterior nasal septum

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