Respiratory effects of TRH microinjections into the nucleus tractus solitarii

The pre-Bötzinger complex participates in generating the respiratory effects of thyroliberin

“…We and other investigators have previously [1,2,9,22] used microinjection techniques on anesthetized rats to demonstrate that a proportion of the respiratory effect of thyroliberin is mediated through the area of the nucleus of the solitary tract. Administration into this site of small doses of this neuropeptide induces increases in pulmonary ventilation and modulates the Hering-Breuer reflex but has no effect on the ventilatory response to hypoxia.…”