Respiratory effects induced by occupational exposure to refractory ceramic fibers

Gu, Yishuo; He, Wei; Wang, Yanhua; Chen, Juan; Wang, Hongfei; Gao, Panjun; Yang, Siwen; Zhu, Xiaojun; Ma, Wenjun; Li, Tao

doi:10.1002/jat.4053

Cited by 7 publications

(4 citation statements)

References 45 publications

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“… 163 A study in Chinese workers reported adverse respiratory effects of RCF and altered lung damage and oxidative markers. 164 …”

Section: Discussionmentioning

confidence: 99%

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Turner,

Cogliano,

Guyton

et al. 2023

Environ Health Perspect

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Background: The International Agency for Research on Cancer (IARC) Monographs program assembles expert working groups who publish a critical review and evaluation of data on agents of interest. These comprehensive reviews provide a unique opportunity to identify research needs to address classification uncertainties. A multidisciplinary expert review and workshop held in 2009 identified research gaps and needs for 20 priority occupational chemicals, metals, dusts, and physical agents, with the goal of stimulating advances in epidemiological studies of cancer and carcinogen mechanisms. Overarching issues were also described. Objectives: In this commentary we review the current status of the evidence for the 20 priority agents identified in 2009. We examine whether identified Research Recommendations for each agent were addressed and their potential impact on resolving classification uncertainties. Methods: We reviewed the IARC classifications of each of the 20 priority agents and identified major new epidemiological and human mechanistic studies published since the last evaluation. Information sources were either the published Monograph for agents that have been reevaluated or, for agents not yet reevaluated, Advisory Group reports and literature searches. Findings are described in view of recent methodological developments in Monographs evidence evaluation processes. Discussion: The majority of the 20 priority agents were reevaluated by IARC since 2009. The overall carcinogen classifications of 9 agents advanced, and new cancer sites with either “sufficient” or “limited” evidence of carcinogenicity were also identified for 9 agents. Examination of published findings revealed whether evidence gaps and Research Recommendations have been addressed and highlighted remaining uncertainties. During the past decade, new research addressed a range of the 2009 recommendations and supported updated classifications for priority agents. This supports future efforts to systematically apply findings of Monograph reviews to identify research gaps and priorities relevant to evaluation criteria established in the updated IARC Monograph Preamble. https://doi.org/10.1289/EHP12547

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“… 163 A study in Chinese workers reported adverse respiratory effects of RCF and altered lung damage and oxidative markers. 164 …”

Section: Discussionmentioning

confidence: 99%

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Turner,

Cogliano,

Guyton

et al. 2023

Environ Health Perspect

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“…ere is a negative correlation between TGF-β1 and CC16 levels, indicating that inhibiting TGF-β1 might enhance the activity of club cells (Gu et al 2021). Hydrogen sul de therapy has been shown to mitigate COPD induced by cigarette smoke through the inhibition of the TGF-β1/Smad pathway (Wang et al 2020a).…”

Section: Introductionmentioning

confidence: 99%

Inactivation of the TGF-β1/ALK5 axis enhances club cell function and alleviates lung tissue damage to ameliorate COPD progression through the MEK/ERK signaling pathway

Tian,

Ouyang,

et al. 2024

gpb

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Chronic obstructive pulmonary disease (COPD) is a highly prevalent and fatal disease worldwide. e function of club cells, which are considered progenitor/stem cells of the bronchial epithelium, and their secreted protein CC16, have been proposed as potential targets for COPD treatment. is study aimed to investigate the role of the TGF-β1/ALK5 signaling pathway in club cell function and COPD progression. C57BL/6J mice were divided into Normal group (exposed to fresh air) and COPD group (exposed to incremental cigarette smoke extract for 12 weeks).e COPD mice were further divided into COPD group, DMSO group, and LY2109761 group (injected with 150 mg/kg LY2109761, a TGF-β1 inhibitor). Tissue staining was used to assess lung damage, and the expression of CC16 was measured. e levels of in ammatory factors and DNA damage-related indicators were also measured. e involvement of the MEK/ERK signaling pathway was determined. COPD mice exhibited severe lung damage and impaired club cell function. Activation of the TGF-β1/ALK5 and MEK/ERK pathways were observed in COPD mice. However, administration of LY2109761 in COPD mice inactivated the TGF-β1/ALK5 and MEK/ ERK pathways. Administration of LY2109761 also alleviated pulmonary brosis, downregulated the levels cleaved caspase-3, IL-4, IL-5, IL-13, IL-12, and IFN-γ, and limited the phosphorylation of Chk1. Moreover, LY2109761 enhanced CC16 expression and decreased lung cell apoptosis. Inactivation of the TGF-β1/ALK5 axis inhibits the MEK/ERK signaling pathway, enhances club cell function, and alleviates lung tissue damage. ese ndings suggest that TGF-β1 is a potential therapeutic target for COPD.

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“…Air concentrations, especially from 1990 to 2010, were highest for those engaged in removal/replacement activities of RCF furnace linings, and in 2002, respiratory protection was required for these activities (Maxim & Utell, 2018; National Toxicology Program [NTP], 2016). A recent study of Chinese RCF workers ( n = 430) compared with controls ( n = 121) indicated that cumulative RCF and dust exposure levels in a non‐dose‐dependent manner were associated with altered levels of lung biomarkers (CC16 and TGF‐β1) and oxidative stress markers (8‐OHdG) (Gu et al, 2020). The International Agency for Research on Cancer (IARC) classified RCF as 2B, possibly carcinogenic to humans (IARC, 2002).…”

Section: Introductionmentioning

confidence: 99%

“…associated with altered levels of lung biomarkers and oxidative stress markers (8-OHdG) (Gu et al, 2020). The International Agency for Research on Cancer (IARC) classified RCF as 2B, possibly carcinogenic to humans (IARC, 2002).…”

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confidence: 99%

Mortality of workers employed in refractory ceramic fiber manufacturing: An update

LeMasters

Lockey

Hilbert

et al. 2022

J of Applied Toxicology

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This study evaluates the possible association between refractory ceramic fiber (RCF) exposure and all causes of death. Current and former employees (n = 1,119) hired from 1952 to 1999 at manufacturing facilities in New York (NY) state and Indiana were included. Work histories and quarterly plant-wide sampling from 1987 to 2015 provided cumulative fiber exposure (CFE) estimates. The full cohort was evaluated as well as individuals with lower and higher exposure, <45 and ≥45 fiber-months/cc.The Life-Table-Analysis-System was used for all standardized mortality rates (SMRs).Person-years at risk were accumulated from start of employment until 12/31/2019 or date of death. There was no significant association with all causes, all cancers, or lung cancer in any group. In the higher exposed, there was a significant elevation in both malignancies of the "urinary organs" (SMR = 3.59, 95% confidence interval[CI] 1.44, 7.40) and "bladder or other urinary site" (SMR = 4.04, 95% CI 1.10, 10.36), which persisted in comparison to regional mortality rates from NY state and Niagara County. However, six of the nine workers with urinary cancers were known smokers.In the lower exposed, there was a significant elevation in malignancies of the lymphatic and hematopoietic system (SMR = 2.54, 95% CI 1.27, 4.55) and leukemia (SMR = 4.21, 95% CI 1.69, 8.67). There was one pathologically unconfirmed mesothelioma death. A second employee currently living with a pathologically confirmed mesothelioma was identified, but the SMR was non-significant when both were included in the analyses. The association of these two mesothelioma cases with RCF exposure alone is unclear because of potential past exposure to asbestos.

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Respiratory effects induced by occupational exposure to refractory ceramic fibers

Cited by 7 publications

References 45 publications

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Research Recommendations for Selected IARC-Classified Agents: Impact and Lessons Learned

Inactivation of the TGF-β1/ALK5 axis enhances club cell function and alleviates lung tissue damage to ameliorate COPD progression through the MEK/ERK signaling pathway

Mortality of workers employed in refractory ceramic fiber manufacturing: An update

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