1981
DOI: 10.1056/nejm198108063050606
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Respiratory Dysrhythmias during Sleep

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Cited by 166 publications
(8 citation statements)
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“…History of snoring also provide a clue to diagnosis. [25] These patients are also candidates for difficult intubation oxygen desaturation in the post operative period is a common occurrence,[26] as well as occurrence of cardiac arrhythmias,[27] haemodynamic instability, myocardial ischemia or infacction and increased incidence of intubation and mechanical ventilation. [28]…”
Section: Discussionmentioning
confidence: 99%
“…History of snoring also provide a clue to diagnosis. [25] These patients are also candidates for difficult intubation oxygen desaturation in the post operative period is a common occurrence,[26] as well as occurrence of cardiac arrhythmias,[27] haemodynamic instability, myocardial ischemia or infacction and increased incidence of intubation and mechanical ventilation. [28]…”
Section: Discussionmentioning
confidence: 99%
“…Such a complex system can become unstable. Instability of the system is best explained by the loop gain principal,144146 which is an engineering concept. Loop gain is the ratio of a corrective response (ventilation) to the disturbance itself.…”
Section: Pathophysiology Of Osamentioning
confidence: 99%
“…Sleep is a time of particular vulnerability when protective upper airway reflexes are attenuated (37, 38, 68, 132, 156, 157), leaving the upper airway susceptible to collapse (102). Recent evidence suggests that the pathogenesis of sleep apnea involves a complex interplay of upper airway anatomy (121), pharyngeal dilator motor control (69, 132), ventilatory control instability (loop gain) (17, 50, 154, 160), alone and/or in combination. The contribution of each of these factors to OSA in a given individual is quite variable (115), emphasizing the importance of defining the underlying mechanism of OSA in afflicted patients to achieve the goal of individualized, targeted therapy (115).…”
Section: Introductionmentioning
confidence: 99%