Respiratory dynamics during laughter

Filippelli, Mario; Pellegrino, Riccardo; Iandelli, Iacopo; Misuri, Gianni; Rodarte, Joseph R.; Duranti, Roberto; Brusasco, Vito; Scano, Giorgio

doi:10.1152/jappl.2001.90.4.1441

Cited by 50 publications

(40 citation statements)

References 10 publications

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“…While a number of studies have reported that laughing is strongly associated with exacerbations of asthma [13,14] there is no current literature on laugh-induced coughing. Possible mechanisms responsible include sudden changes in lung and chest wall mechanics during laughter [15] or in relation to the specific type of humorous stimulation involved and its processing with the cortex (John Widdicombe, personal communication).…”

Section: Clinical Features Of Coughmentioning

confidence: 99%

Are there clinical features of a sensitized cough reflex?

McGarvey

McKeagney²,

Polley

et al. 2009

Pulmonary Pharmacology & Therapeutics

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Key words: sensory hyperresponsiveness, hyperreactivity, cough reflex, receptor AbstractCough reflex hypersensitization is a key feature in patients with troublesome cough. The clinical consequence of this hypersensitive state is typified by bouts of coughing often triggered by low threshold stimuli encountered by the patient during normal daily activities including exposure to aerosols, scents and odours, a change in air temperature and when talking or laughing. These features are often perceived by cough patients to be the most disruptive aspect of their condition and undoubtedly contribute to impaired quality of life.Patients with troublesome cough may describe a range of additional symptoms and sensations including an 'urge to cough' or the feeling of an 'itch' at the back of the throat, or a choking sensation and occasionally chest pain or breathlessness. It is uncertain if these features arise due to the processes responsible for cough reflex sensitisation or as a direct consequence of the underlying cough aetiology. In an attempt to understand the clinical features of a sensitized cough reflex, the spectrum of symptoms typically described by cough patients will be reviewed and possible underlying mechanisms considered. Since an intact cough reflex is crucial to airway protection, anti-tussive treatment that attenuates the hypersensitive cough state rather than abolishing the cough reflex completely would be preferable. Identifying such agents remains a clinical, scientific and pharmacological challenge.

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Section: Clinical Features Of Coughmentioning

confidence: 99%

Are there clinical features of a sensitized cough reflex?

McGarvey

McKeagney²,

Polley

et al. 2009

Pulmonary Pharmacology & Therapeutics

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show abstract

“…Facial, respiratory and laryngeal muscles are all recruited for laughter production 2 leading to changes in lung volume and dynamic compression of the airways. 15 These disturbances of the chest walls and other parts of the body may cause physiological changes requiring increased oxygen consumption leading to a higher HR. Logic suggests that an increase in HR and oxygen consumption should cause an increase in EE.…”

Section: Discussionmentioning

confidence: 99%

Energy expenditure of genuine laughter

et al. 2006

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Objective: To measure energy expenditure (EE) and heart rate (HR) during genuine laughter. Design: Experimental trial of viewing film clips in four cycles either intended to evoke laughter (humorous À10 min) or unlikely to elicit laughter (not humorous À5 min) under strictly controlled conditions of a whole-room indirect calorimeter equipped with audio recording system. Participants: Forty five adult friend dyads in either same-sex male (n ¼ 7), same-sex female (n ¼ 21) and mix-sex male-female (n ¼ 17); age 18-34 years; body mass index 24.774.9 (range 17.9-41.1). Measurements: Energy expenditure in a whole-room indirect calorimeter, HR using Polar HR monitor. Laugh rate, duration and type from digitized audio data using a computerized system and synchronized with HR and EE results. Results: Laughter EE was 0.7971.30 kJ/min (0.1970.31 kcal/min) higher than resting EE (Po0.001, 95% confidence interval ¼ 0.75-0.88 kJ/min), ranging from -2.52 to 9.67 kJ/min (À0.60-2.31 kcal/min). Heart rate during laughter segments increased above resting by 2.173.8 beats/min, ranging from À7.6 to 26.8 beats/min. Laughter EE was correlated with HR (r s ¼ 0.250, Po0.01). Both laughter EE and HR were positively correlated with laughter duration (r s ¼ 0.282 and 0.337, both Po0.001) and rate (r s ¼ 0.256 and 0.298, both Po0.001). Conclusion: Genuine voiced laughter causes a 10-20% increase in EE and HR above resting values, which means that 10-15 min of laughter per day could increase total EE by 40-170 kJ (10-40 kcal).

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“…The mechanisms have not been identified or studied, but there seem to be the two same possibilities that also apply to cough and speech. That the vigorous respiratory and laryngeal movements of laughter [45,46] activate cough sensors in the airways to reach central nervous threshold; or that cerebral cortical mechanisms, activated by particular patterns of …”

Section: Cough and Speechmentioning

confidence: 99%

Workshop – Cough: Exercise, speech and music

Widdicombe

Fontana

Gibson

2009

Pulmonary Pharmacology & Therapeutics

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Twelve distinguished scientists attended the workshop, heard three presentations, and took part in the discussions. Fontana first described his unpublished studies on cough in exercise and during hyperventilation with healthy subjects. Both activities depressed cough induced by inhalation of distilled water aerosol (fog). The possible mechanisms were discussed. Gibson then described the successful use of speech therapy to treat chronic cough, and discussed the possible mechanisms, centering on the role of the larynx and its neural control. A comparison was made with the ability of speech and laughter to precipitate cough. Widdicombe discussed the scanty literature on the effect of singing and playing wind instruments on cough, most of the evidence being anecdotal. In the discussion periods several matters for future study arose. It is usually not clear if the modulation of cough, its depression, enhancement or excitation, arose primarily at peripheral sites (reflexes from the airways), or at a cortical level, or both. Nor is it clear whether the same results would be obtained with provoked cough and with spontaneous cough. But all three aspects of 'behavioual' changes in cough sensitivity (exercise, speech and music) could be further explored, and current techniques should make this possible.

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Respiratory dynamics during laughter

Cited by 50 publications

References 10 publications

Are there clinical features of a sensitized cough reflex?

Are there clinical features of a sensitized cough reflex?

Energy expenditure of genuine laughter

Workshop – Cough: Exercise, speech and music

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