Abstract:Late preterm infants born via elective CS are at high risk for RDS and NICU admission. The risk is influenced by each additional week spent in utero. As the incidence of CS is increasing within this population, new preventative strategies must be sought.
“…The lack of association between GDM and these latter outcomes in twin gestations may once again be attributed to the a priori higher rate of these complications in twins, 12,15,42 which are likely driven by the higher rate of prematurity in twins compared with singletons. 43,44 Indeed, we found that the rate of neonatal hypoglycemia in twins (either with or without GDM) was similar to that of singletons with GDM and considerably higher than that of singletons without GDM.…”
BACKGROUND: Among singleton pregnancies, gestational diabetes mellitus is associated with adverse outcomes. In twin pregnancies, this association may be attenuated, given the higher rate of prematurity and the a priori increased risk of some of these complications. OBJECTIVE: Our aim was to test the hypothesis that gestational diabetes mellitus is less likely to be associated with adverse pregnancy outcomes in twin compared with singleton gestations. METHODS: This retrospective cohort study comprised all twin and singleton live births in Ontario, Canada, 2012e2016. Pregnancy outcomes were compared between women with vs without gestational diabetes mellitus, analyzed separately for twin and singleton births. Adjusted risk ratios and 95% confidence intervals were generated using modified Poisson regression, adjusting for maternal age, nulliparity, smoking, race, body mass index, preexisting hypertension, and assisted reproductive technology. RESULTS: A total of 270,843 women with singleton (n ¼ 266,942) and twin (n ¼ 3901) pregnancies met the inclusion criteria. In both the twin and singleton groups, gestational diabetes mellitus was associated with (adjusted risk ratio, [95% confidence interval]) cesarean delivery (1.11 [1.02e1.21] and 1.20 [1.17e1.23], respectively) and preterm birth at <37 0/7 weeks
“…The lack of association between GDM and these latter outcomes in twin gestations may once again be attributed to the a priori higher rate of these complications in twins, 12,15,42 which are likely driven by the higher rate of prematurity in twins compared with singletons. 43,44 Indeed, we found that the rate of neonatal hypoglycemia in twins (either with or without GDM) was similar to that of singletons with GDM and considerably higher than that of singletons without GDM.…”
BACKGROUND: Among singleton pregnancies, gestational diabetes mellitus is associated with adverse outcomes. In twin pregnancies, this association may be attenuated, given the higher rate of prematurity and the a priori increased risk of some of these complications. OBJECTIVE: Our aim was to test the hypothesis that gestational diabetes mellitus is less likely to be associated with adverse pregnancy outcomes in twin compared with singleton gestations. METHODS: This retrospective cohort study comprised all twin and singleton live births in Ontario, Canada, 2012e2016. Pregnancy outcomes were compared between women with vs without gestational diabetes mellitus, analyzed separately for twin and singleton births. Adjusted risk ratios and 95% confidence intervals were generated using modified Poisson regression, adjusting for maternal age, nulliparity, smoking, race, body mass index, preexisting hypertension, and assisted reproductive technology. RESULTS: A total of 270,843 women with singleton (n ¼ 266,942) and twin (n ¼ 3901) pregnancies met the inclusion criteria. In both the twin and singleton groups, gestational diabetes mellitus was associated with (adjusted risk ratio, [95% confidence interval]) cesarean delivery (1.11 [1.02e1.21] and 1.20 [1.17e1.23], respectively) and preterm birth at <37 0/7 weeks
“…Neonatal respiratory morbidities were linked to scheduled CD and as the rates of CD increase the need for new preventative strategies to reduce respiratory morbidities are required. 4 Tita et al, conducted a large study including 24077 scheduled CD at term and found that that scheduled CD before 39 weeks was linked to respiratory complications, neonatal hypoglycemia, and admission to the NICU. 14 Preventive strategies were recommended to minimize CD related respiratory morbidities.…”
Section: Discussionmentioning
confidence: 99%
“…common respiratory problems were TTN followed by RDS. 3,4 Respiratory complications are inversely correlated to gestational age at the time of delivery. As the gestational age increases, the respiratory complications decrease and vice versa.…”
Background: Caesarean delivery (CD) rates in developing countries are rising beyond the recommended rates of World health organization. Objective of this study was to evaluate whether Dexamethasone injections reduce neonatal incubation admissions when given before scheduled caesarean delivery (CD) at term or not.Methods: A double blinded, two armed, randomized clinical trial was conducted at Tanta University hospitals in the period from October 2017 to March 2019. Four hundred pregnant women admitted for scheduled CD with gestational age ≥37 weeks were included. Patients were randomized into study group and control group. The study group was given 3 dexamethasone doses, 8 mg each while control group was given saline injections simultaneously as a placebo drug. The primary outcome was the neonatal incubatory admissions.Results: Demographic data in both groups were comparable. Transient tachypnea of newborn (TTN) was 15.47% in study group versus 20.33% in control group with p=0.227. The respiratory distress (RDS) in study group was 6.63% versus 9.89% in control group with p=0.260. The incubation admissions were nasal oxygen 12.71% versus 15.38%, continuous positive airway pressure ventilation (CPAP) 5.52% versus 8.24% and mechanical ventilation was 3.87% versus 6.59% in the study and control groups respectively.Conclusions: Although Dexamethasone administration before scheduled CD at term reduced both respiratory morbidity and incubation admissions, the differences between study and control groups were not significant.
“…In 2016, 43% of all deliveries were concluded by caesarean section [7]. Despite epidural anesthesia and the improving quality of perinatal care, caesarean section continues to be associated with increased risks of both maternal and neonatal complications during delivery [8][9][10]. On the other hand, when the incidence of caesarean section rises above 20% in the population it is not matched by a corresponding decrease in maternal or neonatal morbidity.…”
Objectives: To analyze the clinical significance of ophthalmological assessment in pregnant women affected with degenerative retinal lesions, and the lesions' clinical relevance in determining the obstetric management and delivery method. Material and methods: 69 pregnant women affected with retinal degenerative lesions were included in our study. In each patient, the risk of ophthalmological complications during vaginal delivery was evaluated. After the woman's delivery, alignment between the ophthalmological recommendations and the obstetric management were analyzed. Each case where the management plan differed from the clinical proceedings was thoroughly investigated to determine the cause. Results: In 69 pregnant women the risk of ophthalmological complications was evaluated, and in 24 cases (35%) assessed as low, as medium in 37 cases (54%) and as high in 8 cases (11%). Among the 69 patients, 42 of women delivered vaginally and the remaining 27 underwent caesarean section. In the high-risk group, the rate of caesarean section was 87%, while in both the low-and medium-risk groups the rate of vaginal births was 75%. Two years of postnatal ophthalmological follow-up did not reveal any complications that could have been associated with the delivery. Conclusions: Every pregnant woman should undergo ophtalmological examination to assess peripartum risk of complications and determine the method of delivery.
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