1982
DOI: 10.1159/000115493
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Respiratory Disease in Patients with Epilepsy on Single-Drug Therapy with Carbamazepine or Phenobarbital

Abstract: IgA, IgG and IgM concentrations were determined in sera and nasal washings from 20 patients with epilepsy on single-drug treatment with carbamazepine, in 20 patients on single-drug treatment with phenobarbital and in 26 healthy subjects. There were no significant differences in immunoglobulin concentrations between the groups of patients and the controls. Symptoms of respiratory tract disease were recorded daily during 6 months both in patients and in controls. The mean number of days with symptoms from the re… Show more

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Cited by 11 publications
(5 citation statements)
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“…The clinical significance oflowered immunoglobulin A, M and G levels is uncertain, although there is some evidence that intake of phenytoin, but not of carbamazepine or phenobarbitone (Gilhus et al 1982), may be associated with an increased risk of recurrent respiratory infections (Aarli & Gilhus 1983). Phenytoin and ethosuximide intake have both been associated with the presence of circulating antinuclear 328 antibodies in occasional patients (Beernink & Miller 1973).…”
Section: Haematological Effectsmentioning
confidence: 99%
“…The clinical significance oflowered immunoglobulin A, M and G levels is uncertain, although there is some evidence that intake of phenytoin, but not of carbamazepine or phenobarbitone (Gilhus et al 1982), may be associated with an increased risk of recurrent respiratory infections (Aarli & Gilhus 1983). Phenytoin and ethosuximide intake have both been associated with the presence of circulating antinuclear 328 antibodies in occasional patients (Beernink & Miller 1973).…”
Section: Haematological Effectsmentioning
confidence: 99%
“…Individuals with low IgG2 levels have been shown to be at a greater risk of developing infections with several encapsulated bacteria (Siber et al, 1980;Schur, 1987;Plebani et al, 1985). However, even though CBZ reduces IgG2 and other immunoglobulin concentrations in serum, epileptic patients receiving CBZ monotherapy do not have more frequent respiratory tract infections than controls (Gilhus et al, 1982b). This may indicate that the CBZ-induced changes of humoral immune factors are of no major significance for the patient.…”
Section: Discussionmentioning
confidence: 99%
“…Second, current use of carbamazepine was additionally treated as a reference category for mitigating confounding by indication bias. We chose carbamazepine because it is used as an adjunctive therapy for schizophrenia 34 and an alternative therapy for bipolar disorder, 35 and the drug use at usual dose is not linked with ARF 36 . We did not specify the use of carbamazepine for epilepsy because the drug was mainly used as off‐label, such as agitation 37 .…”
Section: Methodsmentioning
confidence: 99%
“…We chose carbamazepine because it is used as an adjunctive therapy for schizophrenia 34 and an alternative therapy for bipolar disorder, 35 and the drug use at usual dose is not linked with ARF. 36 We did not specify the use of carbamazepine for epilepsy because the drug was mainly used as offlabel, such as agitation. 37 Third, we performed stratified analyses by presence or absence of COPD, asthma and heart failure.…”
Section: Additional Analysesmentioning
confidence: 99%