Respiratory Disease in Aggregate Quarry Workers Related to Risk Factors and Pi Phenotype

Montes, Isabel Isidro; Rego, Gumersindo; Camblor, C. Fernández; Quero, Aida; González, Artemio; Rodriguez, Christina

doi:10.1097/01.jom.0000141662.18277.07

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…However, several studies 33 , 34 show elevated CRP levels, a non-specific biomarker, in patients exposed to silica and increasing according to silicosis severity, as was the case in our study. Our series shows elevated levels of alpha-1-AT, in a similar fashion to Montes II et al 35 . The rise in plasma LDH concentration can be also detected in a variety of other processes, such as systemic infections or inflammations, muscle injuries, hemolysis, thromboembolism or malignancies.…”

Section: Discussionsupporting

confidence: 90%

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Blanco-Pérez

Blanco‐Dorado

Rodrı́guez-Garcı́a

et al. 2021

Sci Rep

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Silicosis is a diffuse interstitial lung disease caused by sustained inhalation of silica and silicates. Several cytokines are activated by their inhalation and can mediate the process of pulmonary fibrosis. The identification of biomarkers could allow an early diagnosis before the development of radiological alterations and help monitor the evolution of patients. The objetive of this study was to determine the clinical significance of specific biomarkers, to estimate their association with the development, severity and/or progression of silicosis, and identify determinants of this evolution. We conducted a prospective observational study in patients attending the pulmonology clinic from 2009 to 2018. Serum levels of the following inflammatory mediators were assessed: interleukin-6 (IL-6), interleukin 2 receptor subunit alpha (IL2R) interleukin 1 beta (IL1B), interleukin-8 (IL-8), tumour necrosis factor-alpha (TNF-α), transforming growth factor-beta1 (TGF-β1), alpha-1 antitrypsin (AAT), C-reactive protein (CRP), lactate dehydrogenase (LDH) and ferritin in subjects exposed to silica, with and without silicosis. Association between those inflammatory mediators with lung function measurements and radiological severity of disease and their impact on prognosis were analysed. 337 exposed to silica (278 with silicosis) and 30 subjects in the control group were included. IL-8, α1AT, ferritin, CRP and LDH levels were higher in silicosis than in those exposed to silica without silicosis. IL-8, LDH and AAT levels were associated with progression of silicosis and IL-6, IL-8, LDH, AAT, ferritin, and CRP with vital status. The results of the ROC analysis indicated the potential of IL-8 as a biomarker in the presence of silicosis and for the prediction of mortality.

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Section: Discussionsupporting

confidence: 90%

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Blanco-Pérez

Blanco‐Dorado

Rodrı́guez-Garcı́a

et al. 2021

Sci Rep

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“…21 In arids quarry workers, we have also seen a negative relation between percent predicted FEV1 and mg/m 3 -year of respirable dust multiplied by pack-years. 32 These results are consistent with the findings of Hnizdo 45 in gold mine workers and with the results of the communitybased study carried out by Xu et al 46 The main drawback of our study is its cross-sectional design, which is susceptible to important biases, particularly the healthy worker effect. In this case there should be a relation between exposure and disease, the bias would favor the null hypothesis and would not invalidate the positive findings.…”

Section: Silicosissupporting

confidence: 94%

“…This is in disagreement with results of a previous study conducted in arid quarries, in which we have found a significant positive relation between round opacities and cumulative exposure to respirable dust. 32 This lack of parallelism is remarkable and may be because the afore-mentioned study was performed in limestone quarry workers. Limestone dust contains scant amounts of free silica and the lesions observed were minimal with frequent irregular opacities whereas in the granite study silica exposure was high and there were numerous lesions capable of hiding faint tobacco-induced lesions.…”

Section: Silicosismentioning

confidence: 94%

High Prevalence and Advanced Silicosis in Active Granite Workers: A Dose-Response Analysis Including FEV1

Rego

Pichel²,

Quero³

et al. 2008

Journal of Occupational &Amp; Environmental Medicine

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“…These results confirm previous findings from our group that revealed the occurrence of obstructive and restrictive changes in lungs of silicotic mice (Ferreira et al ., ). The airway hyper‐reactivity verified is in agreement with findings in humans (Forastiere et al ., ; Montes et al ., ). It was shown that exposure to high concentrations of crystalline silica promotes an intense inflammatory response accompanied by cell proliferation and excessive deposition of collagen and other extracellular matrix components, resulting in the development of fibrosis (Mossman and Churg, ).…”

Section: Discussionmentioning

confidence: 97%

Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice

Trentin

Ferreira

Arantes

et al. 2015

British J Pharmacology

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BACKGROUND AND PURPOSEEndogenous glucocorticoids are pro-resolving mediators, an example of which is the endogenous glucocorticoid-regulated protein annexin A1 (ANXA1). Because silicosis is an occupational lung disease characterized by unabated inflammation and fibrosis, in this study we tested the therapeutic properties of the N-terminal ANXA1-derived peptide annexin 1-(2-26) (Ac2-26) on experimental silicosis. EXPERIMENTAL APPROACHSwiss-Webster mice were administered silica particles intranasally and were subsequently treated with intranasal peptide Ac2-26 (200 μg per mouse) or dexamethasone (25 μg per mouse) for 7 days, starting 6 h post-challenge. Ac2-26 abolished the leukocyte infiltration, collagen deposition, granuloma formation and generation of pro-inflammatory cytokines evoked by silica; these variables were only partially inhibited by dexamethasone. KEY RESULTSA clear exacerbation of the silica-induced pathological changes was observed in ANXA1 knockout mice as compared with their wild-type (WT) littermate controls. Incubation of lung fibroblasts from WT mice with Ac2-26 in vitro reduced IL-13 or TGF-β-induced production of CCL2 (MCP-1) and collagen, but this peptide did not affect the production of CCL2 (MCP-1) by stimulated fibroblasts from formyl peptide receptor type 1 (FPR1) knockout mice. Ac2-26 also inhibited the production of CCL2 (MCP-1) from fibroblasts of FPR2 knockout mice. CONCLUSIONS AND IMPLICATIONSCollectively, our findings reveal novel protective properties of the ANXA1 derived peptide Ac2-26 on the inflammatory and fibrotic responses induced by silica, and suggest that ANXA1 mimetic agents might be a promising strategy as innovative anti-fibrotic approaches for the treatment of silicosis. IntroductionSilicosis is a lung occupational disease caused by inhalation of free crystalline silica particles over a prolonged period of time. This disease mainly affects workers in the ceramic industry, glass manufacturing, sandblasting, mining, quarrying and civil construction (Leung et al., 2012;Singer et al., 2012). Silicosis is a problem worldwide, but it is prevalent in countries of low and middle income. China had more than 500 000 cases recorded between 1991 and 1995, and 6000 new cases and more than 24 000 deaths are reported annually (Leung et al., 2012). In Brazil more than 4500 workers were reported to have silicosis between 1978 and 1998, especially in the gold-mining area in Minas Gerais (Carneiro et al., 2006). The irritative action of silica in the lungs results in the formation of nodular lesions, which may coalesce resulting in massive areas of fibrous tissue and reduction of lung elasticity (Davis, 1986). Because of its surface properties, crystalline silica leads to activation of alveolar macrophages [acting on 'scavenger' receptors such as the MARCO (macrophage receptor with collagenous structure)], epithelial cells and fibroblasts (Mossman and Churg, 1998;Fubini and Hubbard, 2003;Huaux, 2007). The granulomatous inflammation induced by silica is characterized by the accumulati...

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Respiratory Disease in Aggregate Quarry Workers Related to Risk Factors and Pi Phenotype

Abstract: Radiologic alterations are found in relation to tobacco. The FEV1 has a negative relation with the product dust-tobacco. No alterations related to Pi phenotype are found. A subgroup with the highest alpha1-antitrypsin levels had more radiologic alterations and worse function.

Cited by 4 publications

References 31 publications

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

Serum levels of inflammatory mediators as prognostic biomarker in silica exposed workers

High Prevalence and Advanced Silicosis in Active Granite Workers: A Dose-Response Analysis Including FEV1

Annexin A1 mimetic peptide controls the inflammatory and fibrotic effects of silica particles in mice

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