Respiratory disease associated with occupational inhalation to hop (Humulus lupulus) during harvest and processing

Reeb-Whitaker, Carolyn; Bonauto, David K.

doi:10.1016/j.anai.2014.07.029

Cited by 17 publications

(6 citation statements)

References 13 publications

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“…For the historical period 2001-2008, we observed 41 cases of WRA from western red cedar and 36 cases from wood dust; here we report an additional 11 cases for western red cedar and 21 cases for wood dust (8). Historic Washington data prior to 2012 identified 25 respiratory disease cases associated with exposure to the hop plant (Humulus lupulus), an agricultural commodity with commercial production centered in this region (39). For the period from 2012 to 2016, an additional 15 cases of WRA from hops were identified, with nine classified as occupational asthma and all associated with hop harvesting and processing activities.…”

Section: Discussionmentioning

confidence: 66%

Surveillance of work-related asthma including the emergence of a cannabis-associated case series in Washington State

2021

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Objective: We conducted surveillance for work-related asthma (WRA) in Washington State to identify the industry sectors and asthma exposures most commonly affecting injured workers and in need of prevention activities.Methods: Using workers' compensation data as the primary data source, valid cases were classified as work-aggravated asthma (WAA) or new onset asthma that includes occupational asthma (OA) and reactive airways dysfunction syndrome (RADS). The source of exposure that caused the worker's asthma, their industry and occupation were determined.Results: There were 784 valid work-related asthma cases identified for the period 2009 -2016, WAA (n=529) was most common followed by occupational asthma (n=127) and RADS (n=12). The Health Care and Social Assistance industry had the highest number of cases (n=170) with 82% classified as WAA. The highest overall proportions of new onset asthma are occurring in Agriculture, Forestry, Fishing and Hunting (33% of work related asthma cases), Manufacturing (31%) and Construction (30%). The leading substances associated with new onset asthma across all industries include hop plant dust, wood and cedar dust, mineral and inorganic dust, mold, and cleaning materials. We describe ten cases of cannabis-associated asthma including seven from workers in the legalized cannabis industry, four of whom had OA. Conclusion:State-based work-related asthma surveillance is critical in identifying the workers and exposures associated with this occupational disease, including the detection of a case-series in the cannabis industry.

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Section: Discussionmentioning

confidence: 66%

Surveillance of work-related asthma including the emergence of a cannabis-associated case series in Washington State

2021

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“…Washington State Workers' Compensation claims filed by Humulus lupulus (hops) workers for respiratory disease between 1995 and 2011 were systematically identified and reviewed in a study of occupational respiratory disease in Humulus lupulus (hops) workers. 102 Incidences of respiratory disease in Humulus lupulus (hops) workers were compared There were no signs of potential irritation in any form of hyper-anemia, hemorrhage, or coagulation. The IP-CAM score was .00 and the product was rated a practically non-irritating under these conditions 95,96 (.06-.12) CFIO.…”

Section: Occupational Exposurementioning

confidence: 99%

Safety Assessment of Hops as Used in Cosmetics

Becker,

Boyer,

Bergfeld

et al. 2023

Int J Toxicol

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The Expert Panel for Cosmetic Ingredient Safety (Panel) assessed the safety of Humulus Lupulus (Hops) Extract (reported functions include antimicrobial agent and hair conditioning agent) and Humulus Lupulus (Hops) Oil (reported function is fragrance). The Panel reviewed the relevant data related to these ingredients. Because final product formulations may contain multiple botanicals, each containing the same constituents of concern, formulators are advised to be aware of these constituents and to avoid reaching levels that may be hazardous to consumers. For these ingredients, the Panel was concerned about the presence of 8-prenylnaringenin, β-myrcene, and quercetin in cosmetics, which could result in estrogenic effects, dermal irritation, and genotoxicity, respectively. Industry should use current good manufacturing practices to limit impurities and constituents of concern. The Panel concluded that Humulus Lupulus (Hops) Extract and Humulus Lupulus (Hops) Oil are safe in cosmetics in the present practices of use and concentration when formulated to be non-sensitizing.

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“…The first group exhibited symptoms mainly in the harvest phase and improved with a period of estrangement from work [41,42]. In Reeb, respiratory disease affected not only new workers employed for less than one year (23%) but also in employees with more than 20 years of experience working for their employer (9%) [43]. With regards to the beekeeper, the authors postulate that the tissue damage caused by toxins in honey bee venom (mellitin and phospholipase) induced disseminated intravascular coagulation (DIC), along with systemic anaphylatic reaction-induced hypotension with subsequent ischemia, which resulted in both stroke and renal failure [41].…”

Section: Case Series and Case Reportmentioning

confidence: 99%

Allergic Anaphylactic Risk in Farming Activities: A Systematic Review

Arcangeli

Traversini

Tomasini

et al. 2020

IJERPH

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Allergic disorders in the agriculture sector are very common among farm workers, causing many injuries and occupational diseases every year. Agricultural employees are exposed to multiple conditions and various allergenic substances, which could be related to onset of anaphylactic reactions. This systematic review highlights the main clinical manifestation, the allergens that are mostly involved and the main activities that are usually involved. This research includes articles published on the major databases (PubMed, Cochrane Library, Scopus), using a combination of keywords. The online search yielded 489 references; after selection, by the authors, 36 articles (nine reviews and 27 original articles) were analyzed. From this analysis, the main clinical problems that were diagnosed in this category were respiratory (ranging from rhinitis to asthma) and dermatological (eczema, dermatitis, hives) in nature, with a wide symptomatology (from a simple local reaction to anaphylaxis). The main activities associated with these allergic conditions are harvesting or cultivation of fruit and cereals, beekeepers and people working in greenhouses. Finally, in addition to the allergens already known, new ones have emerged, including triticale, wine, spider and biological dust. For these reasons, in the agricultural sector, research needs to be amplified, considering new sectors, new technologies and new products, and ensuring a system of prevention to reduce this risk.

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Respiratory disease associated with occupational inhalation to hop (Humulus lupulus) during harvest and processing

Abstract: Occupational exposure to hop dust is associated with respiratory disease. Respiratory disease rates were higher in hop workers than in a comparison group of agricultural workers. Additional research is needed before hop dust can be confirmed as a causative agent for occupational asthma.

Cited by 17 publications

References 13 publications

Surveillance of work-related asthma including the emergence of a cannabis-associated case series in Washington State

Surveillance of work-related asthma including the emergence of a cannabis-associated case series in Washington State

Safety Assessment of Hops as Used in Cosmetics

Allergic Anaphylactic Risk in Farming Activities: A Systematic Review

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