Respiratory, Dermal, and Eye Irritation Symptoms Associated with Corexit™ EC9527A/EC9500A following the
            <i>Deepwater Horizon</i>
            Oil Spill: Findings from the GuLF STUDY

McGowan, Craig; Kwok, Richard K.; Engel, Lawrence S.; Stenzel, Mark; Stewart, Patricia A.; Sandler, Dale P.

doi:10.1289/ehp1677

Cited by 32 publications

(23 citation statements)

References 19 publications

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“…While oil spills have occurred across the world, studies on the associated mid- and long-term health effects have been reported only in three countries: Spain (Prestige oil spill), the USA (Exxon Valdez oil spill [ 19 , 20 , 21 ] and the BPDH oil spill [ 18 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 ]), and Korea (HSOS) [ 2 , 3 , 5 , 6 , 7 , 8 , 9 , 10 , 11 , 12 , 13 , 14 ]. There have been concerns pertaining to the potential development of cancers in the affected areas; however, few studies have focused on the cancer incidence among residents after the oil spill despite their consequent exposure to carcinogenic substances.…”

Section: Introductionmentioning

confidence: 99%

Cancer Incidence Trend in the Hebei Spirit Oil Spill Area, from 1999 to 2014: An Ecological Study

Choi¹,

Park²,

et al. 2018

IJERPH

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The Hebei Spirit oil spill (HSOS) occurred in the Republic of Korea on 7 December 2007. We aimed to describe the cancer incidence trend in Taean County before and after the oil spill. Five major cancers and leukemia were analyzed. Cancer incidence data were obtained from the Korean National Cancer Center. We compared the standardized incidence rates in Taean with those observed nationwide and selected three coastal areas. Joinpoint regression analysis was used to examine the trends in the average annual percent change and perform comparisons. The incidence rate of prostate cancer increased from 2007 to 2009 at an annual average of 39.3% (95% confidence interval (CI): −25.9, 161.8), 13.5% (95% CI: 11.7, 15.4), and 15.6% (95% CI: 11.9, 19.5), respectively, in Taean, nationwide, and in the coastal areas. The incidence of leukemia among women increased at an annual average of 9.5% (95% CI: −26.6, 63.4) in Taean and 0.6% (95% CI: 0.2, 0.9) nationwide; the rate decreased by 1.9% (95% CI: −12.8, 10.4) in the coastal areas. The trends between Taean County and the coastal areas differed only for prostate cancer (p = 0.0004). The incidence of prostate cancer among Taean County residents has increased since the HSOS.

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Section: Introductionmentioning

confidence: 99%

Cancer Incidence Trend in the Hebei Spirit Oil Spill Area, from 1999 to 2014: An Ecological Study

Choi¹,

Park²,

et al. 2018

IJERPH

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“…1 A study in Environmental Health Perspectives explores the relationship between potential exposure to the dispersants used and health complaints in a large cohort of workers who participated in the Deepwater Horizon response and cleanup. 2 The results show an association between exposure to two chemical dispersants and self-reported health outcomes.…”

mentioning

confidence: 84%

“… 5 The results reported in the new study held even after adjusting for estimated exposures to crude oil. 2 …”

mentioning

confidence: 99%

Cleanup in the Gulf: Oil Spill Dispersants and Health Symptoms in Deepwater Horizon Responders

Konkel¹

2018

Environ Health Perspect

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“…The information generated was used to help select a specific dispersant that was used on the spill, Corexit ® 9500. In the years since the Deepwater Horizon disaster, studies have identified potential human health and ecosystem impacts associated with the use of dispersants (Alexander et al 2018;DeLeo et al 2016;McGowan et al 2017;Ramesh et al 2018;Zhang et al 2013), illustrating the complexities and trade-offs decisionmakers face when dealing with unknowns in emergency situations, and where reliance on some rather than no toxicity information may still fall short in the protection of public health and the environment.…”

Section: Environmental and Health Emergenciesmentioning

confidence: 99%

New Toxicology Tools and the Emerging Paradigm Shift in Environmental Health Decision-Making

Ginsberg

Fedinick

Solomon

et al. 2019

Environ Health Perspect

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BACKGROUND: Numerous types of rapid toxicity or exposure assays and platforms are providing information relevant to human hazard and exposure identification. They offer the promise of aiding decision-making in a variety of contexts including the regulatory management of chemicals, evaluation of products and environmental media, and emergency response. There is a need to consider both the scientific validity of the new methods and the values applied to a given decision using this new information to ensure that the new methods are employed in ways that enhance public health and environmental protection. In 2018, a National Academies of Sciences, Engineering, and Medicine (NASEM) workshop examined both the toxicological and societal aspects of this challenge. OBJECTIVES: Our objectives were to explore the challenges of adopting new data streams into regulatory decision-making and highlight the need to align new methods with the information and confidence needs of the decision contexts in which the data may be applied. METHODS: We go beyond the NASEM workshop to further explore the requirements of different decision contexts. We also call for the new methods to be applied in a manner consistent with the core values of public health and environmental protection. We use the case examples presented in the NASEM workshop to illustrate a range of decision contexts that have applied or could benefit from these new data streams. Organizers of the NASEM workshop came together to further evaluate the main themes from the workshop and develop a joint assessment of the critical needs for improved use of emerging toxicology tools in decision-making. We have drawn from our own experience and individual decision or research contexts as well as from the case studies and panel discussions from the workshop to inform our assessment. DISCUSSION: Many of the statutes that regulate chemicals in the environment place a high priority on the protection of public health and the environment. Moving away from the sole reliance on traditional approaches and information sources used in hazard, exposure, and risk assessment, toward the more expansive use of rapidly acquired chemical information via in vitro, in silico, and targeted testing strategies will require careful consideration of the information needed and values considerations associated with a particular decision. In this commentary, we explore the ability and feasibility of using emerging data streams, particularly those that allow for the rapid testing of a large number of chemicals across numerous biological targets, to shift the chemical testing paradigm to one in which potentially harmful chemicals are more rapidly identified, prioritized, and addressed. Such a paradigm shift could ultimately save financial and natural resources while ensuring and preserving the protection of public health. https://doi.

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Respiratory, Dermal, and Eye Irritation Symptoms Associated with Corexit™ EC9527A/EC9500A following the Deepwater Horizon Oil Spill: Findings from the GuLF STUDY

Cited by 32 publications

References 19 publications

Cancer Incidence Trend in the Hebei Spirit Oil Spill Area, from 1999 to 2014: An Ecological Study

Cancer Incidence Trend in the Hebei Spirit Oil Spill Area, from 1999 to 2014: An Ecological Study

Cleanup in the Gulf: Oil Spill Dispersants and Health Symptoms in Deepwater Horizon Responders

New Toxicology Tools and the Emerging Paradigm Shift in Environmental Health Decision-Making

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